Showing papers by "Kazan Federal University published in 2015"

Microbial hotspots and hot moments in soil: Concept & review

Abstract: Soils are the most heterogeneous parts of the biosphere, with an extremely high differentiation of properties and processes within nano- to macroscales. The spatial and temporal heterogeneity of input of labile organics by plants creates microbial hotspots over short periods of time – the hot moments. We define microbial hotspots as small soil volumes with much faster process rates and much more intensive interactions compared to the average soil conditions. Such hotspots are found in the rhizosphere, detritusphere, biopores (including drilosphere) and on aggregate surfaces, but hotspots are frequently of mixed origin. Hot moments are short-term events or sequences of events inducing accelerated process rates as compared to the average rates. Thus, hotspots and hot moments are defined by dynamic characteristics, i.e. by process rates. For this hotspot concept we extensively reviewed and examined the localization and size of hotspots, spatial distribution and visualization approaches, transport of labile C to and from hotspots, lifetime and process intensities, with a special focus on process rates and microbial activities. The fraction of active microorganisms in hotspots is 2–20 times higher than in the bulk soil, and their specific activities (i.e. respiration, microbial growth, mineralization potential, enzyme activities, RNA/DNA ratio) may also be much higher. The duration of hot moments in the rhizosphere is limited and is controlled by the length of the input of labile organics. It can last a few hours up to a few days. In the detritusphere, however, the duration of hot moments is regulated by the output – by decomposition rates of litter – and lasts for weeks and months. Hot moments induce succession in microbial communities and intense intra- and interspecific competition affecting C use efficiency, microbial growth and turnover. The faster turnover and lower C use efficiency in hotspots counterbalances the high C inputs, leading to the absence of strong increases in C stocks. Consequently, the intensification of fluxes is much stronger than the increase of pools. Maintenance of stoichiometric ratios by accelerated microbial growth in hotspots requires additional nutrients (e.g. N and P), causing their microbial mining from soil organic matter, i.e. priming effects. Consequently, priming effects are localized in microbial hotspots and are consequences of hot moments. We estimated the contribution of the hotspots to the whole soil profile and suggested that, irrespective of their volume, the hotspots are mainly responsible for the ecologically relevant processes in soil. By this review, we raised the importance of concepts and ecological theory of distribution and functioning of microorganisms in soil.

A recent bottleneck of Y chromosome diversity coincides with a global change in culture

Abstract: It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50-100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192-307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47-52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.

Losses of soil carbon by converting tropical forest to plantations: erosion and decomposition estimated by δ13C

Abstract: Indonesia lost more tropical forest than all of Brazil in 2012, mainly driven by the rubber, oil palm, and timber industries. Nonetheless, the effects of converting forest to oil palm and rubber plantations on soil organic carbon (SOC) stocks remain unclear. We analyzed SOC losses after lowland rainforest conversion to oil palm, intensive rubber, and extensive rubber plantations in Jambi Province on Sumatra Island. The focus was on two processes: (1) erosion and (2) decomposition of soil organic matter. Carbon contents in the Ah horizon under oil palm and rubber plantations were strongly reduced up to 70% and 62%, respectively. The decrease was lower under extensive rubber plantations (41%). On average, converting forest to plantations led to a loss of 10 Mg C ha−1 after about 15 years of conversion. The C content in the subsoil was similar under the forest and the plantations. We therefore assumed that a shift to higher δ13C values in plantation subsoil corresponds to the losses from the upper soil layer by erosion. Erosion was estimated by comparing the δ13C profiles in the soils under forest and under plantations. The estimated erosion was the strongest in oil palm (35 ± 8 cm) and rubber (33 ± 10 cm) plantations. The 13C enrichment of SOC used as a proxy of its turnover indicates a decrease of SOC decomposition rate in the Ah horizon under oil palm plantations after forest conversion. Nonetheless, based on the lack of C input from litter, we expect further losses of SOC in oil palm plantations, which are a less sustainable land use compared to rubber plantations. We conclude that δ13C depth profiles may be a powerful tool to disentangle soil erosion and SOC mineralization after the conversion of natural ecosystems conversion to intensive plantations when soils show gradual increase of δ13C values with depth.

Toxicity of halloysite clay nanotubes in vivo: a Caenorhabditis elegans study

Abstract: Here we investigated the toxicity of halloysite clay nanotubes in vivo employing a Caenorhabditis elegans nematode as a model organism Using enhanced dark-field microscopy and physiological tests, we found that halloysite is localised exclusively in the alimentary system and does not induce severe toxic effects on nematodes

Noninvasive Reactivation of Motor Descending Control after Paralysis

Abstract: The present prognosis for the recovery of voluntary control of movement in patients diagnosed as motor complete is generally poor. Herein we introduce a novel and noninvasive stimulation strategy of painless transcutaneous electrical enabling motor control and a pharmacological enabling motor control strategy to neuromodulate the physiological state of the spinal cord. This neuromodulation enabled the spinal locomotor networks of individuals with motor complete paralysis for 2–6 years American Spinal Cord Injury Association Impairment Scale (AIS) to be re-engaged and trained. We showed that locomotor-like stepping could be induced without voluntary effort within a single test session using electrical stimulation and training. We also observed significant facilitation of voluntary influence on the stepping movements in the presence of stimulation over a 4-week period in each subject. Using these strategies we transformed brain–spinal neuronal networks from a dormant to a functional state sufficien...

On the maximum accretion luminosity of magnetized neutron stars: connecting X-ray pulsars and ultraluminous X-ray sources

Abstract: We study properties of luminous X-ray pulsars using a simplified model of the accretion column. The maximal possible luminosity is calculated as a function of the neutron star (NS) magnetic field and spin period. It is shown that the luminosity can reach values of the order of $10^{40}\,{\rm erg/s}$ for the magnetar-like magnetic field ($B\gtrsim 10^{14}\,{\rm G}$) and long spin periods ($P\gtrsim 1.5\,{\rm s}$). The relative narrowness of an area of feasible NS parameters which are able to provide higher luminosities leads to the conclusion that $L\simeq 10^{40}\,\,{\rm erg/s}$ is a good estimate for the limiting accretion luminosity of a NS. Because this luminosity coincides with the cut-off observed in the high mass X-ray binaries luminosity function which otherwise does not show any features at lower luminosities, we can conclude that a substantial part of ultra-luminous X-ray sources are accreting neutron stars in binary systems.

Liquid Organic Hydrogen Carriers: Thermophysical and Thermochemical Studies of Benzyl- and Dibenzyl-toluene Derivatives

Abstract: The heat transfer oils dibenzyltoluene and benzyltoluene are promising materials as a new class of liquid organic hydrogen carrier compounds (LOHC). Thermophysical properties (heat capacity, density, viscosity, and surface tension) of the commercially available thermofluids Marlothem LH (benzyltoluene) and Marlotherm SH (dibenzyltoluene) and their completely hydrogenated derivatives were measured. Thermochemical properties (enthalpies of combustion and enthalpies of vaporization) were derived from experiments. Gas-phase molar enthalpies of formation were derived and validated with group-additivity and high-level quantum chemical calculations. Enthalpies of the hydrogenation/dehydrogenation reactions of the LOHC pairs under study were derived.

Thermochemistry of Halogen-Substituted Methylbenzenes

Abstract: Experimental vapor pressures, vaporization, fusion, and sublimation enthalpies of a number of bromo- and iodo-substituted methylbenzenes have been studied by transpiration method in order to evaluate a series of experimental measurements that appear to be internally self-consistent. The compounds studied in this regard include bromobenzene, iodobenzene, 1-bromo-2-methylbenzene, 1-bromo-3-methylbenzene, 1-bromo-4-methylbenzene, 1-iodo-2-methylbenzene, 1-iodo-3-methylbenzene, 1-iodo-4-methylbenzene, 1-bromo-2,6-dimethylbenzene, 1-iodo-2,6-dimethylbenzene, and 1-iodo-2,4-dimethylbenzene. Gas-phase enthalpies of formation of halogen-substituted methylbenzenes were calculated by using quantum-chemical methods. Simple group-additivity procedures were developed for estimation of vaporization enthalpies and gas-phase and liquid-phase enthalpies of formation of halogen-substituted methylbenzenes.

The critical accretion luminosity for magnetized neutron stars

Abstract: The accretion flow around X-ray pulsars with a strong magnetic field is funnelled by the field to relatively small regions close to the magnetic poles of the neutron star (NS), the hotspots. During strong outbursts regularly observed from some X-ray pulsars, the X-ray luminosity can be so high, that the emerging radiation is able to stop the accreting matter above the surface via radiation-dominated shock, and the accretion column begins to rise. This border luminosity is usually called the "critical luminosity". Here we calculate the critical luminosity as a function of the NS magnetic field strength $B$ using exact Compton scattering cross section in strong magnetic field. Influence of the resonant scattering and photon polarization is taken into account for the first time. We show that the critical luminosity is not a monotonic function of the B-field. It reaches a minimum of a few 10^{36} erg s^{-1} when the cyclotron energy is about 10 keV and a considerable amount of photons from a hotspot have energy close to the cyclotron resonance. For small B, this luminosity is about 10^{37} erg s^{-1}, nearly independent of the parameters. It grows for the B-field in excess of 10^{12} G because of the drop in the effective cross-section of interaction below the cyclotron energy. We investigate how different types of the accretion flow and geometries of the accretion channel affect the results and demonstrate that the general behaviour of the critical luminosity on B-field is very robust. The obtained results are shown to be in a good agreement with the available observational data and provide a necessary ground for the interpretation of upcoming high quality data from the currently operating and planned X-ray telescopes.

Atlas of the Postnatal Rat Brain in Stereotaxic Coordinates

Abstract: The series of atlases of the developing rat brain in stereotaxic coordinates that we propose here1,2 has been conceived as a tool for the exploration of the rat brain in vivo during the postnatal period, offering a choice of bregma and lambda as the reference points. We suggest to use this atlas, which provides stereotaxic coordinates, in combination with other histological atlases, where brain structures and boundaries between them were assessed using histochemistry or quantative magnetic resonance techniques, but where stereotaxic coordinates are not available (Ramachandra and Subramanian, 2011; Calabrese et al., 2013; Ashwell and Paxinos, 2015) or provided (at P10, P21, and P39) but not within the bregma-lambda metrics (Sherwood and Timiras, 1970). The neonatal rat is a powerful model for the study of the early stages of central nervous system development. Comparative developmental studies suggest that the first two postnatal weeks in the rat roughly correspond to the second half of gestation and the early postnatal period in humans, with the electrical brain activity patterns expressed during this period and their developmental trajectories matching the patterns observed in premature human neonates (Clancy et al., 2001, 2007; Khazipov and Luhmann, 2006; Colonnese et al., 2010; Workman et al., 2013) (see also http://www.translatingtime.net/). Recent advances in the understanding of the developing brain functions largely came from the use of techniques to record brain activity from neonatal and adolescent rats in vivo, notably in head restrained animals (Leinekugel et al., 2002; Khazipov et al., 2004; Minlebaev et al., 2011; Tiriac et al., 2012; Yang et al., 2013). However, the rat brain grows rapidly and non-proportionally during the postnatal period and brain structures change their position in relation to the conventional skull marks such as bregma and lambda, making difficult to perform targeted recordings, stimulations, lesions, or local drug injections in precise anatomical locations. Hence the importance of a developmental atlas of the rat brain in stereotaxic coordinates. Several examples of histology atlases series of the developing rat brain have been published (Table ​(Table1).1). The Atlas by Sherwood and Timiras “A Stereotaxic Atlas of the Developing Rat Brain” atlas includes three postnatal time points: postnatal days P10, P21, and P39 (Sherwood and Timiras, 1970). Ashwell and Paxinos' “Atlas of the Developing Rat Nervous System” provides photographs and accompanying diagrams of coronal and sagittal sections of rats aged E12, E13, E14, E16, E17, E19, and P0 (Ashwell and Paxinos, 2015). “Atlas of the Neonatal Rat Brain” by Ramachandra and Subramanian describes rat brains at P1, P7, and P14 (Ramachandra and Subramanian, 2011). More recently, Calabrese, Badea, Watson, and Johnson published their “Quantitative magnetic resonance histology atlas of postnatal rat brain development with regional estimates of growth and variability” based on the study of P0, P2, P4, P8, P12, P18, P24, P40, and P80 rats (Calabrese et al., 2013). Among these atlases, only the atlas by Sherwood and Timiras (1970) provides stereotaxic coordinates and yet for only three postnatal days P10, 21, and P39. Stereotaxic atlases for the early postnatal period are not available, however. Table 1 Atlases of the developing rat brain. The series of atlases of the developing rat brain in stereotaxic coordinates that we propose here has been conceived as a tool for the exploration of the rat brain in vivo during the postnatal period, offering a choice of bregma and lambda as the reference points. Each atlas contains a series of microphotographs of wet, non-stained 200 micron coronal brain sections in oblique light, obtained from postnatal days P0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 14, and 21 rats, with an indication of the main brain structures. Wet non-stained sections were used to avoid deformation, shrinkage and lessening associated with staining and mounting procedures, particularly when manipulating immature tissue. Because we did not stain sections, the images do not provide cellular resolution and not all brain structures and boundaries between them can be easily identified. Therefore, only certain brain structures are labeled without boundaries. Used in combination with the existing high image resolution atlases of the developing rat brain (Sherwood and Timiras, 1970; Ramachandra and Subramanian, 2011; Calabrese et al., 2013; Ashwell and Paxinos, 2015), this atlas may be useful for targeted recordings, stimulations, and drug injections in different brain structures at various postnatal ages. This atlas has been successfully used in several previous studies (Minlebaev et al., 2011; Petit et al., 2014; Tyzio et al., 2014).

Enzyme-activated intracellular drug delivery with tubule clay nanoformulation.

Abstract: Fabrication of stimuli-triggered drug delivery vehicle s is an important milestone in treating cancer. Here we demonstrate the selective anticancer drug delivery into human cells with biocompatible 50-nm diameter halloysite nanotube carriers. Physically-adsorbed dextrin end stoppers secure the intercellular release of brilliant green. Drug-loaded nanotubes penetrate through the cellular membranes and their uptake efficiency depends on the cells growth rate. Intercellular glycosyl hydrolases-mediated decomposition of the dextrin tube-end stoppers triggers the release of the lumen-loaded brilliant green, which allowed for preferable elimination of human lung carcinoma cells (А549) as compared with hepatoma cells (Hep3b). The enzyme-activated intracellular delivery of brilliant green using dextrin-coated halloysite nanotubes is a promising platform for anticancer treatment.

Epigenetics in lung cancer diagnosis and therapy

Abstract: Lung cancer is the leading cause of cancer-related deaths worldwide. The initiation and progression of lung cancer is the result of the interaction between permanent genetic and dynamic epigenetic alterations. DNA methylation is the best studied epigenetic mark in human cancers. Altered DNA methylation in cancer was identified in 1983. Within 30 years of this discovery, DNA methylation inhibitors are used clinically to treat a variety of cancers, highlighting the importance of the epigenetic basis of cancer. In addition, histone modifications, nucleosome remodeling, and micro RNA (miRNA)-mediated gene regulation are also fundamental to tumor genesis. Distinct chromatin alterations occur in all stages of lung cancer, including initiation, growth, and metastasis. Therefore, stage-specific epigenetic changes can be used as powerful and reliable tools for early diagnosis of lung cancer and to monitor patient prognosis. Moreover, since epigenetic changes are dynamic and reversible, chromatin modifiers are promising targets for the development of more effective therapeutic strategies against cancer. This review summarizes the chromatin alterations in lung cancer, focusing on the diagnostic and therapeutic approaches targeting epigenetic modifications that could help to reduce the high case-fatality rate of this dreadful disease.

The effect of hydrostatic pressure up to 1.61 GPa on the Morin transition of hematite‐bearing rocks: Implications for planetary crustal magnetization

Abstract: We present new experimental data on the dependence of the Morin transition temperature (TM) on hydrostatic pressure up to 1.61 GPa, obtained on a well-characterized multidomain hematite-bearing sample from a banded iron formation. We used a nonmagnetic high-pressure cell for pressure application and a Superconducting Quantum Interference Device magnetometer to measure the isothermal remanent magnetization (IRM) under pressure on warming from 243 K to room temperature (T0). IRM imparted at T0 under pressure in 270 mT magnetic field (IRM270mT) is not recovered after a cooling-warming cycle. Memory effect under pressure was quantified as IRM recovery decrease of 10%/GPa. TM, determined on warming, reaches T0 under hydrostatic pressure 1.38–1.61 GPa. The pressure dependence of TM up to 1.61 GPa is positive and essentially linear with a slope dTM/dP = (25 ± 2) K/GPa. This estimate is more precise than previous ones and allows quantifying the effect of a pressure wave on the upper crust magnetization, with special emphasis on Mars.

Assessing the Impact of Infrastructure on Economic Growth and Global Competitiveness

Abstract: The aim of this research is to examine the degree of the influence of infrastructure on national competitiveness. Through an effectiveness of infrastructure management can improve industrial policy and gain national competitiveness. According to research of the World Bank there are several factors influencing the economy growth effectiveness and national competitiveness, including institutions, infrastructure, macroeconomic environment, health and primary education, technological readiness, market size, etc and also, there are various frameworks, models, and analytical tools that can be used in studying the causal relationships between some key infrastructure factors and national competitiveness. Based on existing models, this study aims to identify and discuss the key infrastructure factors that determine national competitiveness, which in turn influence positively on the total results of industrial policy. The results of study showed that national competitiveness is influenced basically by the level of institutional development and other seven factors, including infrastructure, in turn infrastructure factor is determined mainly by the quality of roads, railroad infrastructure, air transport and electricity supply. The key institutional traps were singled out that prevent the development of the national economy. These findings contribute to an understanding of the key factors that determine economic growth, help to explain what infrastructure factors allows to be more successful in raising income levels and offer policymakers and business leaders an important tool in the formulation of improved economic policies and institutional reforms.

Gene Expression Profiling of H9c2 Myoblast Differentiation towards a Cardiac-Like Phenotype

Abstract: H9c2 myoblasts are a cell model used as an alternative for cardiomyocytes. H9c2 cells have the ability to differentiate towards a cardiac phenotype when the media serum is reduced in the presence of all-trans-retinoic acid (RA), creating multinucleated cells with low proliferative capacity. In the present study, we performed for the first time a transcriptional analysis of the H9c2 cell line in two differentiation states, i.e. embryonic cells and differentiated cardiac-like cells. The results show that RA-induced H9c2 differentiation increased the expression of genes encoding for cardiac sarcomeric proteins such as troponin T, or calcium transporters and associated machinery, including SERCA2, ryanodine receptor and phospholamban as well as genes associated with mitochondrial energy production including respiratory chain complexes subunits, mitochondrial creatine kinase, carnitine palmitoyltransferase I and uncoupling proteins. Undifferentiated myoblasts showed increased gene expression of pro-survival proteins such as Bcl-2 as well as cell cycle-regulating proteins. The results indicate that the differentiation of H9c2 cells lead to an increase of transcripts and protein levels involved in calcium handling, glycolytic and mitochondrial metabolism, confirming that H9c2 cell differentiation induced by RA towards a more cardiac-like phenotype involves remodeled mitochondrial function. PI3K, PDK1 and p-CREB also appear to be involved on H9c2 differentiation. Furthermore, complex analysis of differently expressed transcripts revealed significant up-regulation of gene expression related to cardiac muscle contraction, dilated cardiomyopathy and other pathways specific for the cardiac tissue. Metabolic and gene expression remodeling impacts cell responses to different stimuli and determine how these cells are used for biochemical assays.

Loss of labile organic carbon from subsoil due to land-use changes in subtropical China

Abstract: Topsoil carbon (C) stocks are known to decrease as a consequence of the conversion of natural ecosystems to plantations or croplands; however, the effect of land use change on subsoil C remains unknown. Here, we hypothesized that the effect of land use change on labile subsoil organic C may be even stronger than for topsoil due to upward concentration of plantations and crops root systems. We evaluated soil labile organic C fractions, including particulate organic carbon (POC) and its components [coarse POC and fine POC], light fraction organic carbon (LFOC), readily oxidizable organic carbon, dissolved organic carbon (DOC) and microbial biomass down to 100 cm soil depth from four typical land use systems in subtropical China. Decrease in fine root biomass was more pronounced below 20 cm than in the overlying topsoil (70% vs. 56% for plantation and 62% vs. 37% for orchard. respectively) driving a reduction in subsoil labile organic C stocks. Land use changes from natural forest to Chinese fir plantation, Chinese chestnut orchard, or sloping tillage reduced soil organic C stocks and that of its labile fractions both in top and subsoil (20–100 cm). POC reduction was mainly driven by a decrease in fine POC in topsoil, while DOC was mainly reduced in subsoil. Fine POC, LFOC and microbial biomass can be useful early indicators of changes in topsoil organic C. In contrast, LFOC and DOC are useful indicators for subsoil. Reduced proportions of fine POC, LFOC, DOC and microbial biomass to soil organic C reflected the decline in soil organic C quality caused by land use changes. We conclude that land use changes decrease C sequestration both in topsoil and subsoil, which is initially indicated by the labile soil organic C fractions.

Planck 2013 results - XXXII. The updated Planck catalogue of Sunyaev-Zeldovich sources

Abstract: We update the all-sky Planck catalogue of 1227 clusters and cluster candidates (PSZ1) published in March 2013, derived from detections of the Sunyaev–Zeldovich (SZ) effect using the first 15.5 months of Planck satellite observations. As an addendum, we deliver an updated version of the PSZ1 catalogue, reporting the further confirmation of 86 Planck-discovered clusters. In total, the PSZ1 now contains 947 confirmed clusters, of which 214 were confirmed as newly discovered clusters through follow-up observations undertaken by the Planck Collaboration. The updated PSZ1 contains redshifts for 913 systems, of which 736 (~ 80.6%) are spectroscopic, and associated mass estimates derived from the Yz mass proxy. We also provide a new SZ quality flag for the remaining 280 candidates. This flag was derived from a novel artificial neural-network classification of the SZ signal. Based on this assessment, the purity of the updated PSZ1 catalogue is estimated to be 94%. In this release, we provide the full updated catalogue and an additional readme file with further information on the Planck SZ detections.

Direct-to-consumer genetic testing for predicting sports performance and talent identification: Consensus statement.

Abstract: The general consensus among sport and exercise genetics researchers is that genetic tests have no role to play in talent identification or the individualised prescription of training to maximise performance. Despite the lack of evidence, recent years have witnessed the rise of an emerging market of direct-to-consumer marketing (DTC) tests that claim to be able to identify children's athletic talents. Targeted consumers include mainly coaches and parents. There is concern among the scientific community that the current level of knowledge is being misrepresented for commercial purposes. There remains a lack of universally accepted guidelines and legislation for DTC testing in relation to all forms of genetic testing and not just for talent identification. There is concern over the lack of clarity of information over which specific genes or variants are being tested and the almost universal lack of appropriate genetic counselling for the interpretation of the genetic data to consumers. Furthermore independent studies have identified issues relating to quality control by DTC laboratories with different results being reported from samples from the same individual. Consequently, in the current state of knowledge, no child or young athlete should be exposed to DTC genetic testing to define or alter training or for talent identification aimed at selecting gifted children or adolescents. Large scale collaborative projects, may help to develop a stronger scientific foundation on these issues in the future.

Efficient Synchronization of Dipolarly Coupled Vortex-Based Spin Transfer Nano-Oscillators.

Abstract: Due to their nonlinear properties, spin transfer nano-oscillators can easily adapt their frequency to external stimuli. This makes them interesting model systems to study the effects of synchronization and brings some opportunities to improve their microwave characteristics in view of their applications in information and communication technologies and/or to design innovative computing architectures. So far, mutual synchronization of spin transfer nano-oscillators through propagating spinwaves and exchange coupling in a common magnetic layer has been demonstrated. Here we show that the dipolar interaction is also an efficient mechanism to synchronize neighbouring oscillators. We experimentally study a pair of vortex-based spin transfer nano-oscillators, in which mutual synchronization can be achieved despite a significant frequency mismatch between oscillators. Importantly, the coupling efficiency is controlled by the magnetic configuration of the vortices, as confirmed by an analytical model and micromagnetic simulations highlighting the physics at play in the synchronization process.

Cosmological perturbations in a mimetic matter model

Abstract: We investigate the cosmological evolution of a mimetic matter model with arbitrary scalar potential. The cosmological reconstruction---which is the method for constructing a model for an arbitrary evolution of the scale factor---is explicitly performed for different choices of potential. The cases where the mimetic matter model shows the evolution as cold dark matter (CDM), the $w\mathrm{CDM}$ model, dark matter and dark energy with a dynamical $Om(z)$ [where $Om(z)\ensuremath{\equiv}[(H(z)/{H}_{0}{)}^{2}\ensuremath{-}1]/[(1+z{)}^{3}\ensuremath{-}1]$], and phantom dark energy with a phantom-nonphantom crossing are presented in detail. The cosmological perturbations for such evolutions are studied in the mimetic matter model. For instance, the evolution behavior of the matter density contrast (which is different than the usual one, i.e., $\stackrel{\ifmmode\ddot\else\textasciidieresis\fi{}}{\ensuremath{\delta}}+2H\stackrel{\ifmmode \dot{}\else \textperiodcentered \fi{}}{\ensuremath{\delta}}\ensuremath{-}{\ensuremath{\kappa}}^{2}\ensuremath{\rho}\ensuremath{\delta}/2=0$) is investigated. The possibility of a peculiar evolution of $\ensuremath{\delta}$ in the model under consideration is shown. Special attention is paid to the behavior of the matter density contrast near the future singularity, where the decay of perturbations may occur much earlier than the singularity.

Supercritical accretion disks in ultraluminous X-ray sources and SS 433

Abstract: The brightest extragalactic black holes emit X-rays with intensities that are thousands of times greater than those from black holes within our Galaxy. However, optical spectra suggest these different sources may be more similar than once thought.

The neutron star in HESS J1731−347: Central compact objects as laboratories to study the equation of state of superdense matter

Abstract: Context. Central compact objects (CCOs) in supernova remnants are isolated thermally emitting neutron stars (NSs). They are most probably characterized by a magnetic field strength that is roughly two orders of magnitude lower than that of most of the radio and accreting pulsars. The thermal emission of CCOs can be modeled to obtain constraints on the physical parameters of the star such as its mass, radius, effective temperature, and chemical composition. Aims. The CCO in HESS J1731−347 is one of the brightest objects in this class. Starting from 2007, it was observed several times with different X-ray satellites. Here we present our analysis of two new XMM-Newton observations of the source performed in 2013 which increase the total exposure time of the data available for spectral analysis by a factor of about five compared to the analyses presented before. Methods. We use our numerical spectral models for carbon and hydrogen atmospheres to fit the spectrum of the CCO. From our fits, we derive constraints on the physical parameters of the emitting star such as its mass, radius, distance, and effective temperature. We also use the new data to derive new upper limits on the source pulsations and to confirm the absence of a long-term flux and spectral variability. Results. The analysis shows that atmosphere models are clearly preferred by the fit over the blackbody spectral function. Under the assumption that the X-ray emission is uniformly produced by the entire star surface (supported by the lack of pulsations), hydrogen atmosphere models lead to uncomfortably large distances of the CCO, above 7–8 kpc. On the other hand, the carbon atmosphere model formally excludes distances above 5–6 kpc and is compatible with the source located in the Scutum-Crux (∼3 kpc) or NormaCygnus (∼4.5 kpc) Galactic spiral arm. We provide and discuss the corresponding confidence contours in the NS mass–radius plane. The measured effective temperature indicates that the NS is exceptionally hot for the estimated age of ∼30 kyr. We discuss possible cooling scenarios to explain this property, as well as possible additional constraints on the star mass and radius from cooling theory.

Exploring the limits for reduction of plastid genomes: a case study of the mycoheterotrophic orchids Epipogium aphyllum and Epipogium roseum.

Abstract: The question on the patterns and limits of reduction of plastid genomes in nonphotosynthetic plants and the reasons of their conservation is one of the intriguing topics in plant genome evolution. Here, we report sequencing and analysis of plastid genome in nonphotosynthetic orchids Epipogium aphyllum and Epipogium roseum, which, with sizes of 31 and 19 kbp, respectively, represent the smallest plastid genomes characterized by now. Besides drastic reduction, which is expected, we found several unusual features of these "minimal" plastomes: Multiple rearrangements, highly biased nucleotide composition, and unprecedentedly high substitution rate. Only 27 and 29 genes remained intact in the plastomes of E. aphyllum and E. roseum-those encoding ribosomal components, transfer RNAs, and three additional housekeeping genes (infA, clpP, and accD). We found no signs of relaxed selection acting on these genes. We hypothesize that the main reason for retention of plastid genomes in Epipogium is the necessity to translate messenger RNAs (mRNAs) of accD and/or clpP proteins which are essential for cell metabolism. However, these genes are absent in plastomes of several plant species; their absence is compensated by the presence of a functional copy arisen by gene transfer from plastid to the nuclear genome. This suggests that there is no single set of plastid-encoded essential genes, but rather different sets for different species and that the retention of a gene in the plastome depends on the interaction between the nucleus and plastids.

Separation Performance of BioRenewable Deep Eutectic Solvents

Abstract: Deep eutectic solvents (DESs) have been regarded as promising cost-effective and environmentally benign alternatives to conventional volatile organic solvents. The screening and selection of the suitable solvent for separation is an important part of the process design. Limiting activity coefficients provide a useful tool for the optimal choice of the selective solvent. For the first time, activity coefficients at infinite dilution have been measured in DESs as a solvent for 23 solutes (aliphatic and aromatic hydrocarbons, alcohols, ketones, ethers, and esters). The DESs were constituted from choline chloride and glycerol in molar ratios of 1:1 and 1:2. The measurements were carried out with the help of gas–liquid chromatography in the temperature range 298–358 K. Using experimental results, selectivity of different separation cases was assessed. To verify the separation performance of DESs the perturbed-chain statistical associating fluid theory (PC-SAFT) was employed for the first time. This method appe...

Spinal segment-specific transcutaneous stimulation differentially shapes activation pattern among motor pools in humans

Abstract: Transcutaneous and epidural electrical spinal cord stimulation techniques are becoming more valuable as electrophysiological and clinical tools. Recently, we observed selective activation of proximal and distal motor pools during epidural spinal stimulation. In the present study, we hypothesized that the characteristics of recruitment curves obtained from leg muscles will reflect a relative preferential activation of proximal and distal motor pools based on their arrangement along the lumbosacral enlargement. The purpose was to describe the electrophysiological responses to transcutaneous stimulation in leg muscles innervated by motoneurons from different segmental levels. Stimulation delivered along the rostrocaudal axis of the lumbosacral enlargement in the supine position resulted in a selective topographical recruitment of proximal and distal leg muscles, as described by threshold intensity, slope of the recruitment curves, and plateau point intensity and magnitude. Relatively selective recruitment of proximal and distal motor pools can be titrated by optimizing the site and intensity level of stimulation to excite a given combination of motor pools. The slope of the recruitment of particular muscles allows characterization of the properties of afferents projecting to specific motoneuron pools, as well as to the type and size of the motoneurons. The location and intensity of transcutaneous spinal electrical stimulation are critical to target particular neural structures across different motor pools in investigation of specific neuromodulatory effects. Finally, the asymmetry in bilateral evoked potentials is inevitable and can be attributed to both anatomical and functional peculiarities of individual muscles or muscle groups.

Fielded Sequential Dependence Model for Ad-Hoc Entity Retrieval in the Web of Data

Abstract: Previously proposed approaches to ad-hoc entity retrieval in the Web of Data (ERWD) used multi-fielded representation of entities and relied on standard unigram bag-of-words retrieval models. Although retrieval models incorporating term dependencies have been shown to be significantly more effective than the unigram bag-of-words ones for ad hoc document retrieval, it is not known whether accounting for term dependencies can improve retrieval from the Web of Data. In this work, we propose a novel retrieval model that incorporates term dependencies into structured document retrieval and apply it to the task of ERWD. In the proposed model, the document field weights and the relative importance of unigrams and bigrams are optimized with respect to the target retrieval metric using a learning-to-rank method. Experiments on a publicly available benchmark indicate significant improvement of the accuracy of retrieval results by the proposed model over state-of-the-art retrieval models for ERWD.

Dynamical features of scalar-torsion theories

Abstract: We investigate the cosmological dynamics in teleparallel gravity with nonminimal coupling. We analytically extract several asymptotic solutions, and we numerically study the exact phase-space behavior. Comparing the obtained results with the corresponding behavior of nonminimal scalar-curvature theory, we find significant differences, such as the rare stability and the frequent presence of oscillatory behavior.

Circulating Microparticles Alter Formation, Structure, and Properties of Fibrin Clots

Abstract: Despite the importance of circulating microparticles in haemostasis and thrombosis, there is limited evidence for potential causative effects of naturally produced cell-derived microparticles on fibrin clot formation and its properties. We studied the significance of blood microparticles for fibrin formation, structure, and susceptibility to fibrinolysis by removing them from platelet-free plasma using filtration. Clots made in platelet-free and microparticle-depleted plasma samples from the same healthy donors were analyzed in parallel. Microparticles accelerate fibrin polymerisation and support formation of more compact clots that resist internal and external fibrinolysis. These variations correlate with faster thrombin generation, suggesting thrombin-mediated kinetic effects of microparticles on fibrin formation, structure, and properties. In addition, clots formed in the presence of microparticles, unlike clots from the microparticle-depleted plasma, contain 0.1-0.5-μm size granular and CD61-positive material on fibres, suggesting that platelet-derived microparticles attach to fibrin. Therefore, the blood of healthy individuals contains functional microparticles at the levels that have a procoagulant potential. They affect the structure and stability of fibrin clots indirectly through acceleration of thrombin generation and through direct physical incorporation into the fibrin network. Both mechanisms underlie a potential role of microparticles in haemostasis and thrombosis as modulators of fibrin formation, structure, and resistance to fibrinolysis.