Kazan Federal University

About: Kazan Federal University is a education organization based out in Kazan’, Russia. It is known for research contribution in the topics: Population & Chemistry. The organization has 9868 authors who have published 14390 publications receiving 135726 citations. The organization is also known as: Kazan (Volga region) Federal University & Kazan State University.

Polarization angle swings in blazars: The case of 3C 279

Abstract: International Max Planck Research School (IMPRS) for Astronomy and Astrophysics at the Max Planck Institute for Radio Astronomy; Universities of Bonn and Cologne; Academy of Finland project [274477]; NASA Fermi GI grant [NNX11AQ03G]; Russian Foundation for Basic Research [13-02-12103, 14-02-31789]; RFBR [12-02-01237a]; UNAM DGAPA-PAPIIT [IN116211-3]; Ramon y Cajal grant of the Spanish Ministry of Economy and Competitiveness (MINECO); Spanish Ministry of Economy and Competitiveness (Spain); Regional Government of Andalucia (Spain) [AYA2010-14844, AYA2013-40825-P, P09-FQM-4784]; Fermi Guest Investigator [NNX08AW56G, NNX09AU10G, NNX12AO93G, NNX14AQ58G]; Russian RFBR [15-02-00949]; St. Petersburg University research [6.38.335.2015]; Shota Rustaveli National Science Foundation [FR/638/6-320/12, 31/77]

Ba 2 YIrO 6 : A cubic double perovskite material with Ir 5 + ions

Abstract: Materials with a $5{d}^{4}$ electronic configuration are generally considered to have a nonmagnetic ground state ($J=0$). Interestingly, ${\mathrm{Sr}}_{2}{\mathrm{YIrO}}_{6}$ (${\mathrm{Ir}}^{5+}$ having $5{d}^{4}$ electronic configuration) was recently reported to exhibit long-range magnetic order at low temperature and the distorted ${\mathrm{IrO}}_{6}$ octahedra were discussed to cause the magnetism in this material. Hence, a comparison of structurally distorted ${\mathrm{Sr}}_{2}{\mathrm{YIrO}}_{6}$ with cubic ${\mathrm{Ba}}_{2}{\mathrm{YIrO}}_{6}$ may shed light on the source of magnetism in such ${\mathrm{Ir}}^{5+}$ materials with $5{d}^{4}$ configuration. Besides, ${\mathrm{Ir}}^{5+}$ materials having $5{d}^{4}$ are also interesting in the context of recently predicted excitonic types of magnetism. Here we report a single-crystal-based analysis of the structural, magnetic, and thermodynamic properties of ${\mathrm{Ba}}_{2}{\mathrm{YIrO}}_{6}$. We observe that in ${\mathrm{Ba}}_{2}{\mathrm{YIrO}}_{6}$ for temperatures down to 0.4 K, long-range magnetic order is absent but at the same time correlated magnetic moments are present. We show that these moments are absent in fully relativistic ab initio band-structure calculations; hence, their origin is presently unclear.

The biological basis and clinical symptoms of CAR-T therapy-associated toxicites.

Abstract: Currently, immunotherapy is attracting a lot of attention and may potentially become a leading approach in the treatment of cancer One emerging therapeutic, the chimeric-antigen receptor T-cell adoptive immunotherapy (CAR-T) is showing remarkable efficacy in the treatment of several B-cell malignancies The popularity of CAR-T has been founded on two CAR T-cell products recently approved by FDA (during 2017) in the treatment of relapsed/refractory B-cell acute lymphoblastic leukemia and B-cell lymphoma However, their toxicities observed in clinical trials were extremely significant and in some cases even fatal with no approved algorithms for toxicity prediction being available to date A deeper understanding of the biological basis of such complications is the key to prompt and comprehensive clinical management Here we review the wide spectrum of effects associated with CAR T cell therapy with a major focus on the pathogenesis of cytokine release syndrome and neurotoxicity as the most common, potentially life-threatening effects of this treatment We discuss the basis of clinical management and the existing models that predict the severity of toxicity, as well as the key factors that modulate this event Finally, we will summarize the literature detailing universal allogenic CAR T-cells and their toxicity profile

Planck 2013 results. V. LFI calibration

Abstract: We present a description of the pipeline used to calibrate the Planck Low Frequency Instrument (LFI) timelines into thermodynamic temperatures for the Planck 2015 data release, covering four years of uninterrupted operations. As in the 2013 data release, our calibrator is provided by the spin-synchronous modulation of the cosmic microwave background dipole, but we now use the orbital component, rather than adopting the Wilkinson Microwave Anisotropy Probe (WMAP) solar dipole. This allows our 2015 LFI analysis to provide an independent Solar dipole estimate, which is in excellent agreement with that of HFI and within 1σ (0.3% in amplitude) of the WMAP value. This 0.3% shift in the peak-to-peak dipole temperature from WMAP and a general overhaul of the iterative calibration code increases the overall level of the LFI maps by 0.45% (30 GHz), 0.64% (44 GHz), and 0.82% (70 GHz) in temperature with respect to the 2013 Planck data release, thus reducing the discrepancy with the power spectrum measured by WMAP. We estimate that the LFI calibration uncertainty is now at the level of 0.20% for the 70 GHz map, 0.26% for the 44 GHz map, and 0.35% for the 30 GHz map. We provide a detailed description of the impact of all the changes implemented in the calibration since the previous data release.

Therapeutic Prospects of Extracellular Vesicles in Cancer Treatment.

Abstract: Extracellular vesicles (EVs) are released by all cells within the tumor microenvironment, such as endothelial cells, tumor-associated fibroblasts, pericytes and immune system cells. The EVs carry the cargo of parental cells formed of proteins and nucleic acids, which can convey cell-to-cell communication influencing the maintenance and spread of the malignant neoplasm, for example promoting angiogenesis, tumor cell invasion and immune escape. However, EVs can also suppress tumor progression, either by the direct influence of the protein and nucleic acid cargo of the EVs or via antigen presentation to immune cells as tumor derived EVs carry on their surface some of the same antigens as the donor cells. Moreover, dendritic cell-derived EVs carry MHC class I and class II/peptide complexes and are able to prime other immune system cell types and activate an anti-tumor immune response. Given the relative longevity of vesicles within the circulation and their ability to cross blood-brain barriers, modification of these unique organelles offers the potential to create new biological-tools for cancer therapy. This review examines how modification of the EV cargo has the potential to target specific tumor mechanisms responsible for tumor formation and progression to develop new therapeutic strategies and to increase the efficacy of antitumor therapies.