Showing papers by "Loma Linda University published in 1972"

Clinical experience with mitomycin C in large infrequent doses.

Abstract: One hundred and six patients (103 solid tumors, three lymphomas) were treated with large infrequent doses of mitomycin C. Thirteen patients in this group received combined radiation and chemotherapy and were evaluated separately. Most patients received 50 mg of the drug in a divided dose during the first week of treatment. After 6 weeks, maintenance injections of 10 to 30 mg of the drug were given to responsive patients at 4‐ to 6‐week intervals. Twenty‐two per cent of the patients showed a 50% reduction in tumor mass for a month or longer. Patients with breast and gastrointestinal carcinoma responded most frequently. The remission rates and durations are similar to those of published studies using other dosage schedules. Toxic effects have been similar though possibly less frequent. There appears to be no therapeutic advantage in using large infrequent doses of the drug; however, the time‐saving to both patient and medical staff has been significant.

Brain Extracellular Space and Membrane Morphology Variations with Preparative Procedures

Abstract: When considering extracellular space and plasma membrane structure in the brain, duration of postfixation in osmium tetroxide and embedding procedure are equally as important as the dehydrating agent employed. The use of ethanol instead of acetone for dehydration does not adequately explain the finding of a 5-30 nm space instead of apposed membranes. In this investigation it was found that postfixation for 3 h stabilized the tissue sufficiently so that ethanol or acetone dehydration followed by Vestopal W, Epon 812, or Araldite 502 embedding produced similar results, and apposed, triple-layered plasma membranes were prevalent. In contrast, when postfixed for a shorter time, namely 90, 45 or 30 min, ethanol dehydration followed by Epon embedding resulted in the common ‘20-nm’ extracellular space and only partially triple-layered plasma membranes. The same tissue dehydrated with acetone and Vestopal embedded looked much like the equivalent 3-h postfixed material, i.e. it had apposed, triple-layered plasma membranes. When acetone dehydration and Epon embedding, or ethanol dehydration and Vestopal embedding were used with tissue of short postfixation time, the results were comparable. Apposed membranes interspersed with erratic amounts of extracellular space were common and plasma membranes tended to show an indistinct outer leaflet. Taken together the results indicate that the presence of apposed triple-layered plasma membranes is at least as valid as the common finding of a 20-nm space and partially tri-laminar membranes.

Photographic Study of Gold Flow

Abstract: This is a study of the action of molten gold alloy during the actual casting process. The action was recorded by high-speed photography through a silica window. An understanding of the directional forces of the molten alloy is helpful for space location and orientation of the casting ring.

The Effects of Three Preschool Intervention Programs on the Development of Autonomy in Mexican-American and Negro Children.

Abstract: 'This study was the basis for a doctoral dissertation by the senior author and was supported, In part, by the UCLA Early Childhood Research Center and funded by OE-5-85-045 and OEO 4117. Past research has indicated that disadvantaged children score significantly below middle-class children on tests of intelligence, language development, and reasoning when they begin school (cf. Kuzma, 1970). Furthermore, it has been noted that a progressive decrement in performance occurs, so that by the time disadvantaged children reach junior high school, 60% are from 1 to 4 years below grade level in reading skills. A wide variety of preschool programs, ranging from developmental middle-class nursery school models to highly structured verbal-bombardment interventions, have been developed to help disadvantaged children acquire those skills which are essential for school success. The effectiveness of these compensatory programs has usually been assessed by such measures as the StanfordBinet (S-8), the Peabody Picture Vocabulary Test (PPVT), and the Illinois Test of Psycholinguistic Abilities (ITPA). The results have indicated that children in experimental programs make significantly greater gains than children in no program at all, and that the children in cognitively oriented, structured classrooms obtain higher scores than those in developmental classrooms (e.g., Edwards & Stern, 1970; Stearns, 1971). Although curiosity, creativity, reflectivity, field independence, persistence, and similar autonomy variables are highly valued by preschool specialists, few programs have directed their emphases specifically to the development of these behaviors, despite the findings of Banta (1967) that lower-class children are not as autonomous as middle-class children. Of particular importance to the designers of compensatory programs was his comment that the structure

Growth inhibitors rapidly inactivated by the host as potential antineoplastic agents in intra-arterial infusion chemotherapy

Abstract: Certain compounds capable of blocking the growth of cultured animal cells or causing them to lose viability upon prolonged exposure may have no apparent effect upon tumor growth in vivo,

Ramus Endosseous Frame Implant for Use with Patient’s Denture: Report of Case

Abstract: A one-piece endosseous implant was designed for use in the mandible. The posterior portion of the implant is lodged between the buccal and lingual plates of cortical bone. The anterior portion, which can be adjusted, is fitted into the symphysis region. With use of an acrylic resin, the patient’s denture can be molded to the shape of the superstructure of the implant. Advantages of the implant include one treatment visit, decreased surgical time, reduced cost, and decreased patient discomfort.

Study of a granulopoietin from endotoxin-stimulated mouse plasma.

Abstract: Summary: The presence of a granulopoietic stimulating factor was demonstrated in the plasma and marrow interstitial fluid of mice 18 hr following the injection of E. coli endotoxin or turpentine, when maximum polymorphonuclear leucocyte depletion occurs in the marrow. Stimulation was evident in the marrows of C57B1 mice from an increase in the absolute number of immature granulocytes, as well as by an increased 3H-thymidine uptake in the marrow. The effect was also shown to be concentration-dependent. It can be differentiated from the stimulatory effect which results from marrow granulocyte depletion (a secondary effect), since there was no significant loss of granulocytes from the marrow upon administration of the active preparations. It is therefore distinct from Gordon's leucocyte inducing factor.

Change in Methylation of Salmonella Bacteriophage P3 Deoxyribonucleic Acid with Host-Controlled Modification by Escherichia coli

Abstract: Modification of bacteriophage P3 by passage through Escherichia coli K was correlated with a 54% decrease in the content of 6-methylaminopurine in the phage deoxyribonucleic acid.

Workable Community Concepts in Drug Abuse

Abstract: Self-actualization, confidence and trust from adults, and the development of meaningful goals are becoming more difficult for young people to achieve and realize. Drug abuse, with most regular drug...

The Nebular Hypothesis of Isaac Orr

Abstract: Students of eighteenthand early-nineteenth-century astronomy occasionally stumble onto a forgotten nebular hypothesis that had heretofore been eclipsed by the shadow of Laplace. As recently as 1959 S. Yajima added one more name-that of the Japanese scholar Tadao Shizuki (1760-1806)-to the list of those who had more or less independently devised a nebular explanation of the origin of the solar system.' Equally deserving of attention is the work of an obscure but creative American minister named Isaac Orr (1793-1844). Orr graduated from Yale College in 1818, studied theology, and then became a teacher in Thomas H. Gallaudet's Asylum for the Deaf and Dumb in Hartford, Connecticut. Later he served as an agent of the American Colonization Society and as secretary of the African Education Society. His fascination with cosmogonieal problems undoubtedly stemmed from his close association with Yale's youthful professor of mathematics and natural philosophy, Alexander Metcalf Fisher, who assisted him in developing his cosmogony and promised to present it before the leading European scientists. Misfortune intervened, however. In 1822 Fisher drowned in the shipwreck of the Albion off the Irish coast.! Bereft of his friend and collaborator, Orr turned for advice to America's foremost mathematician in the early-nineteenth century, Nathaniel Bowditch of Salem, Massachusetts. When Bowditch saw the similarity. between the ideas of Laplace and those of Orr, he sent the latter a copy of the passage in the Systeme du monde outlining the nebular hypothesis. From that extract Orr first learned that he had been anticipated. His initial reaction was \"that it would be useless, and perhaps improper to publish [his speculation]. But on close examination and comparison, there appeared sufficient reasons to change that opinion\".:! In November 1822, he submitted his theory to the American journal ofscience and arts, where it appeared the following year. Like so many others before him, Orr was persuaded that various phenomena of the solar system-most obviously, the direction and positions of the orbits of the planets and satellites-\"are much too regular to be considered the pure effects of accident, while on the other hand, they are not sufficiently so to be attributed to the immediate operations of an intelligent designing agent\".\" Very likely they indicated a common mode of development, which Orr set forth as follows:

Fluorides in neoplastic disease.

Abstract: If patients have malignant osteolytic bone lesions, they may benefit from taking fluorides by mouth. Fluorides relieve pain, and in about 40 percent of patients, increase the x-ray density of osteolytic lesions. Fluorides tend to strengthen and harden the bones, thereby decreasing the possibility of fractures, compression and deformity.

Class III direct-gold restoration for adolescents

Abstract: The Class III direct-gold restoration for adolescents has proved to be the finest restoration for young people, a rewarding experience for the dentist, and a financially sound procedure.