Institution
Northeast Agricultural University
Education•Harbin, China•
About: Northeast Agricultural University is a education organization based out in Harbin, China. It is known for research contribution in the topics: Gene & Population. The organization has 14428 authors who have published 9850 publications receiving 126705 citations. The organization is also known as: Dōngběi Nóngyè Dàxué.
Topics: Gene, Population, Oxidative stress, Chemistry, Apoptosis
Papers published on a yearly basis
Papers
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TL;DR: It is concluded that the Cd treatment promoted an imbalance of the antioxidant status and activated the PI3K/Akt pathway, leading to necroptosis in chicken peripheral blood lymphocytes, and that ASB was able to partially ameliorate the effect of Cd-induced necroPTosis.
59 citations
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TL;DR: The results indicated that magnetic COF-DtTb possesses superior trace enrichment properties for organophosphorus pesticides in fruits.
59 citations
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TL;DR: In this article, a glasshouse study compared the growth and phosphorus efficiency of 96 genotypes of soybean [ Glycine max (L.) Merrill] in a P-deficient soil.
59 citations
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TL;DR: The immunomodulatory effects of Bacillus-based DFMs on innate immunity in broiler chickens are described and NO production by PBMC-derived macrophages stimulated with IFNγ or LPS was apparent, although the effect was strain-dependent.
59 citations
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TL;DR: In this article, the effect of selenium on LPS-induced myocardial inflammation in chickens was explored, and the results showed that LPS stimulation inhibited miR-128-3p, which increased the expression of p38MAPK and NF-κB.
Abstract: Selenium is closely related to the occurrence of heart disease, and an appropriate amount of selenium can alleviate inflammatory changes caused by various factors. Lipopolysaccharide (LPS), as a specific component of the cell wall of Gram-negative bacteria, is often used to construct various inflammatory models. In order to explore the effect of selenium on LPS-induced myocardial inflammation in chickens, we chose 4-month-old laying hens to be fed with a selenium-rich diet containing 0.5 g kg−1 Se, and injected LPS into the abdominal cavity at the age of 8 months to establish an inflammation model. We observed the myocardial tissue lesions by light microscopy, and detected miR-128-3p, p38MAPK, and NF-κB pathway-associated inflammatory factors and Th1/Th2 related factors by qRT-PCR and Western blot. The results showed that LPS stimulation inhibited miR-128-3p, which increased the expression of p38MAPK and NF-κB, while the expression of TNF-α, IL-1, PTGE, COX-2 and iNOS increased. Additionally, the expression of IL-4 and IL-6 increased and IFN-γ decreased, suggesting an imbalance of Th1/Th2. We also found that LPS treatment not only increased the content of H2O2 and MDA in the myocardium, but also increased the expression of HSP60, HSP70 and HSP90, while the activity of SOD, GPX and CAT and the content of GSH decreased. Interestingly, the addition of selenium can alleviate the changes in the above indicators. Finally, we concluded that selenium inhibits the occurrence of oxidative stress and ultimately alleviates myocardial inflammation induced by LPS through the miR-128-3p-p38MAPK-NF-κB pathway.
59 citations
Authors
Showing all 14506 results
Name | H-index | Papers | Citations |
---|---|---|---|
Xin Li | 114 | 2778 | 71389 |
Yongsheng Chen | 107 | 465 | 55962 |
Qian Liu | 90 | 610 | 33341 |
Di Wu | 87 | 965 | 48697 |
Xia Li | 85 | 1121 | 30293 |
Mingyao Liu | 82 | 854 | 31501 |
Jian Jin | 68 | 323 | 17018 |
Tong Wu | 66 | 591 | 19325 |
Xin Liu | 63 | 680 | 22868 |
Yong Qing Fu | 60 | 646 | 15576 |
Yujie Feng | 59 | 414 | 13894 |
Jae H. Kang | 57 | 219 | 11951 |
Qi Zhou | 56 | 299 | 14141 |
Yi-Fan Li | 56 | 214 | 10934 |
Nian X. Sun | 50 | 330 | 9210 |