Institution
Northeast Agricultural University
Education•Harbin, China•
About: Northeast Agricultural University is a education organization based out in Harbin, China. It is known for research contribution in the topics: Gene & Population. The organization has 14428 authors who have published 9850 publications receiving 126705 citations. The organization is also known as: Dōngběi Nóngyè Dàxué.
Topics: Gene, Population, Oxidative stress, Chemistry, Apoptosis
Papers published on a yearly basis
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TL;DR: The results indicated that both acute and chronic cold stress could cause duodenum oxidative stress and change in iNOS, which was related to the intestinal damage process.
70 citations
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TL;DR: The results provide a reference for large-scale production of CLSP by submerged fermentation and suggested that CLSP had potent antioxidant activity and could be explored as a potential dietary supplement to retard aging and attenuate age-related diseases in humans.
70 citations
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TL;DR: A novel mechanism in which DEX protects against LPS-induced AKI is demonstrated, which results in the removal of damaged mitochondria and reduces oxidative stress and apoptosis in L PS- induced AKI through the α2-AR and inhibition of the PI3K/AKT/mTOR pathway.
Abstract: Background Acute kidney injury (AKI) is often secondary to sepsis. Previous studies suggest that damaged mitochondria and the inhibition of autophagy results in AKI during sepsis, but dexmedetomidine (DEX) alleviates lipopolysaccharide (LPS)-induced AKI. However, it is uncertain whether the renoprotection of DEX is related to autophagy or the clearance of damaged mitochondria in sepsis-induced AKI. Methods In this study, AKI was induced in rats by injecting 10 mg/kg of LPS intraperitoneally (i.p.). The rats were also pretreated with DEX (30 μg/kg, i.p.) 30 min before the injection of LPS. The structure and function of kidneys harvested from the rats were evaluated, and the protein levels of autophagy-related proteins, oxidative stress levels, and apoptosis levels were measured. Further, atipamezole (Atip) and 3-Methyladenine (3-MA), which are inhibitors of DEX and autophagy, respectively, were administered before the injection of DEX to examine the protective mechanism of DEX. Results Pretreatment with DEX ameliorated kidney structure and function. DEX decreased the levels of blood urea nitrogen (BUN) and creatinine (Cre), urine kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), reactive oxygen species (ROS), and apoptosis proteins (such as cleaved caspase-9 and cleaved caspase-3). However, DEX upregulated the levels of autophagy and mitophagy proteins, such as Beclin-1, LC3 II and PINK1. These results suggest that DEX ameliorated LPS-induced AKI by reducing oxidative stress and apoptosis and enhancing autophagy. To promote autophagy, DEX inhibited the phosphorylation levels of PI3K, AKT, and mTOR. Furthermore, the administration of Atip and 3-MA inhibitors blocked the renoprotection effects of DEX. Conclusions Here, we demonstrate a novel mechanism in which DEX protects against LPS-induced AKI. DEX enhances autophagy, which results in the removal of damaged mitochondria and reduces oxidative stress and apoptosis in LPS-induced AKI through the α2-AR and inhibition of the PI3K/AKT/mTOR pathway.
70 citations
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TL;DR: Inspired by people to make flour food, a one-pot, low-cost, green and environmental friendly gas foaming strategy is adopted here to prepare the three-dimensional hierarchical porous carbon (HPC) by introducing NaHCO3 as foaming and activation agent as mentioned in this paper.
70 citations
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TL;DR: The results reported here indicate that the oxidative stress and mitochondrial damage caused by ATR metabolism may play a crucial role in the apoptosis of carp neutrophils, and enrich the immunotoxicological mechanisms of ATR observed in fish.
70 citations
Authors
Showing all 14506 results
Name | H-index | Papers | Citations |
---|---|---|---|
Xin Li | 114 | 2778 | 71389 |
Yongsheng Chen | 107 | 465 | 55962 |
Qian Liu | 90 | 610 | 33341 |
Di Wu | 87 | 965 | 48697 |
Xia Li | 85 | 1121 | 30293 |
Mingyao Liu | 82 | 854 | 31501 |
Jian Jin | 68 | 323 | 17018 |
Tong Wu | 66 | 591 | 19325 |
Xin Liu | 63 | 680 | 22868 |
Yong Qing Fu | 60 | 646 | 15576 |
Yujie Feng | 59 | 414 | 13894 |
Jae H. Kang | 57 | 219 | 11951 |
Qi Zhou | 56 | 299 | 14141 |
Yi-Fan Li | 56 | 214 | 10934 |
Nian X. Sun | 50 | 330 | 9210 |