Northumbria University

About: Northumbria University is a education organization based out in Newcastle upon Tyne, United Kingdom. It is known for research contribution in the topics: Context (language use) & Population. The organization has 5624 authors who have published 17423 publications receiving 381949 citations. The organization is also known as: University of Northumbria at Newcastle.

Lung function and microbiota diversity in cystic fibrosis

Abstract: Chronic infection and concomitant airway inflammation is the leading cause of morbidity and mortality for people living with cystic fibrosis (CF). Although chronic infection in CF is undeniably polymicrobial, involving a lung microbiota, infection surveillance and control approaches remain underpinned by classical aerobic culture-based microbiology. How to use microbiomics to direct clinical management of CF airway infections remains a crucial challenge. A pivotal step towards leveraging microbiome approaches in CF clinical care is to understand the ecology of the CF lung microbiome and identify ecological patterns of CF microbiota across a wide spectrum of lung disease. Assessing sputum samples from 299 patients attending 13 CF centres in Europe and the USA, we determined whether the emerging relationship of decreasing microbiota diversity with worsening lung function could be considered a generalised pattern of CF lung microbiota and explored its potential as an informative indicator of lung disease state in CF. We tested and found decreasing microbiota diversity with a reduction in lung function to be a significant ecological pattern. Moreover, the loss of diversity was accompanied by an increase in microbiota dominance. Subsequently, we stratified patients into lung disease categories of increasing disease severity to further investigate relationships between microbiota characteristics and lung function, and the factors contributing to microbiota variance. Core taxa group composition became highly conserved within the severe disease category, while the rarer satellite taxa underpinned the high variability observed in the microbiota diversity. Further, the lung microbiota of individual patient were increasingly dominated by recognised CF pathogens as lung function decreased. Conversely, other bacteria, especially obligate anaerobes, increasingly dominated in those with better lung function. Ordination analyses revealed lung function and antibiotics to be main explanators of compositional variance in the microbiota and the core and satellite taxa. Biogeography was found to influence acquisition of the rarer satellite taxa. Our findings demonstrate that microbiota diversity and dominance, as well as the identity of the dominant bacterial species, in combination with measures of lung function, can be used as informative indicators of disease state in CF.

Bacterial sensors define intracellular free energies for correct enzyme metalation.

Abstract: There is a challenge for metalloenzymes to acquire their correct metals because some inorganic elements form more stable complexes with proteins than do others. These preferences can be overcome provided some metals are more available than others. However, while the total amount of cellular metal can be readily measured, the available levels of each metal have been more difficult to define. Metal-sensing transcriptional regulators are tuned to the intracellular availabilities of their cognate ions. Here we have determined the standard free energy for metal complex formation to which each sensor, in a set of bacterial metal sensors, is attuned: the less competitive the metal, the less favorable the free energy and hence the greater availability to which the cognate allosteric mechanism is tuned. Comparing these free energies with values derived from the metal affinities of a metalloprotein reveals the mechanism of correct metalation exemplified here by a cobalt chelatase for vitamin B12.

Daubing the drudges of fury: men, violence and the piety of the hegemonic masculinity thesis

Abstract: This paper was selected alongside other articles written by Prof. Tony Jefferson and Prof. Robert Connell, (leading international theorists of ‘masculinities’), as the pivot of a special issue of Theoretical Criminology. The article is a forceful critique of the popular concept of ‘hegemonic masculinity’, questioning its theoretical integrity and relevance to the criminological study of masculinity and violence. It has been selected by Prof. Steven Tomsen for inclusion in the International ‘Library of Criminology, Criminal Justice and Penology’, an anthology of classic articles, and is cited in criminology textbooks, including The Blackwell Companion to Criminology and A Textbook on Criminology. A substantial body of empirical work suggests that young, economically marginalised males are the most likely perpetrators and victims of serious physical violence. Interpreting these findings in a historicised way that has been neglected by the criminological discourses of the moment suggests that physical violence has become an increasingly unsuccessful strategy in the quest for social power in liberal-capitalist societies. Although it has been displaced by symbolic violence as the principal domineering force in capitalism’s historical project, physical violence has not been genuinely discouraged but harnessed as a specialist practice in a pseudo-pacification process. From this perspective, violence has a complex relationship with liberalcapitalism. Can the concept of ‘hegemonic masculinity’ help criminology to deal with this complexity and inform violence reduction strategies? This article argues that, in the context of pseudo-pacification, the notion that violent males ‘rework the themes’ of an institutionally powerful ‘hegemonic masculinity’ inverts and distorts the concept of hegemony, which for Gramsci was the self-affirming cultural production of the dominant political-economic class. Thus the concept of ‘hegemonic masculinity’ tends to downplay political economy and class power, which suggests that it is too far removed from historical processes and material contexts to either justify the use of the term hegemony itself or explain the striking social patterns of male violence. This intellectual retreat is representative of a general political evacuation of capitalism’s global socio-economic processes, a move that is allowing sparsely regulated market forces to continue the economic insecurity, specialist roles and corresponding cultural forms that reproduce the traditional male propensity to physical violence.

Using protection motivation theory in the design of nudges to improve online security behavior

Abstract: We conducted an online experiment (n = 2024) on a representative sample of internet users in Germany, Sweden, Poland, Spain and the UK to explore the effect of notifications on security behaviour. Inspired by protection motivation theory (PMT), a coping message advised participants on how to minimize their exposure to risk and a threat appeal highlighted the potential negative consequences of not doing so. Both increased secure behavior – but the coping message significantly more so. The coping message was also as effective as both messages combined, but not so the threat appeal. Risk attitudes, age and country had a significant effect on behavior. Initiatives seeking to promote secure behavior should focus more on coping messages, either alone or in combination with fear appeals.

Intervention against excessive alcohol consumption in primary health care: a survey of GPs' attitudes and practices in England 10 years on.

Abstract: Aims: To ascertain the views of general practitioners (GPs) regarding the prevention and management of alcohol- related problems in practice, together with perceived barriers and incentives for this work; to compare our findings with a comparable survey conducted 10 years earlier. Methods: In total, 282 (73%) of 419 GPs surveyed in East Midlands, UK, completed a postal questionnaire, measuring practices and attitudes, including the Shortened Alcohol and Alcohol Problems Perception Questionnaire (SAAPPQ). Results: GPs reported lower levels of post-graduate education or training on alcohol-related issues (<4 h for the majority) than in 1999 but not significantly so (P= 0.031). In the last year, GPs had most commonly requested more than 12 blood tests and managed 1-6 patients for alcohol. Reports of these preventive practices were significantly increased from 1999 (P< 0.001). Most felt that problem or dependent drinkers' alcohol issues could be legitimately (88%, 87%) and adequately (78%, 69%) addressed by GPs. However, they had low levels of motivation (42%, 35%), task-related self-esteem (53%, 49%) and job satisfaction (15%, 12%) for this. Busyness (63%) and lack of training (57%) or contractual incentives (48%) were key barriers. Endorsement for gov- ernment policies on alcohol was very low. Conclusion: Among GPs, there still appears to be a gap between actual practice and potential for preventive work relating to alcohol problems; they report little specific training and a lack of support. Translational work on understanding the evidence-base supporting screening and brief intervention could incentivize intervention against excessive drinking and embedding it into everyday primary care practice.