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Public Health Research Institute
Healthcare•
About: Public Health Research Institute is a based out in . It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 4889 authors who have published 8149 publications receiving 276945 citations.
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TL;DR: Comparisons showed that chromosomal supercoiling decreased in the absence of HU and increased toward wild-type levels in the presence of a spontaneous gyrB suppressor, establishing that HU has a physiological role in chromosomal DNA topology, probably by facilitating the action of gyrase.
86 citations
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TL;DR: Evidence is provided that when aiming to understand individual differences in self‐control, one should take genetic factors into account, with stronger heritability estimates based on parent report versus self‐report or observations.
86 citations
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TL;DR: Influenza virus single- and double-stranded RNAs have been examined by polyacrylamide-gel electrophoresis on slab gels and eight RNA segments have been demonstrated, and these are grouped as three large, three intermediate, and two small segments.
86 citations
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TL;DR: A model has been presented that proposes that the program of serially dependent packaging is determined by the conformational changes at the surface of the procapsid due to the amount of RNA packaged at each step.
86 citations
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TL;DR: This study first found that hypertension and male patients with 41–50 years old were independent risk factors for HMKP infections, and the composition of ST types and PFGE clusters among K. pneumoniae K2 isolates was more diverse than K1 isolates.
Abstract: A distinctive syndrome caused by hypermucoviscous Klebsiella pneumoniae (HMKP) including pyogenic liver abscess (PLA) is now becoming a globally emerging disease. In the present study, 22.8% (84/369) of K. pneumoniae clinical isolates associated with various types of invasive infections were identified as HMKP, with 45.2% associated with PLA. Multivariate regression analysis showed that male patients with 41-50 years, PLA, diabetes mellitus, and hypertension were independent risk factors for HMKP infections. K2 (42.9%, 36/84) was the most common capsular serotype among HMKP isolates, followed by K1 (23.8%, 20/84). Seventy-five percentage of K1 HMKP isolates were associated with PLA, while K2 HMKP isolates accounted for more types of invasive infections. The positive rates of iutA, mrkD, aerobactin, iroN, and rmpA among HMKP isolates were significantly higher than those among non-HMKP isolates (p < 0.05). There was a correlation between magA, ybtS, alls, and wcaG and K1 isolates. Interestingly, mrkD was exclusively detected among HMKP (32.1%, 27/84) and K2 isolates (65.9%, 27/41). All K1 and K2 HMKP and non-HMKP isolates were positive for rmpA. Aerobactin was found among 95.0 and 97.5% of K1 and K2 isolates. ST23 was found to be the most prevalent ST among 69 HMKP isolates with K1, K2, K5, K20, and K57 (27.5%, 19/69) and was only found among K1 isolates. ST65 was the second most prevalent ST (26.1%, 18/69) and was also only found among K2 isolates. ST23-K1 HMKP isolates (84.2%, 16/19) were associated with PLA, while ST65-K2 isolates were correlated with more types of infections relative to ST23-K1 isolates. PFGE results showed that the homology of 84 HMKP isolates was diverse. Only five PFGE clusters with more than 75% similarity accounted for more than three isolates. These five PFGE clusters only accounted for 35 (41.7%, 35/84) isolates. In conclusion, our study first found that hypertension and male patients with 41-50 years old were independent risk factors. The composition of ST types and PFGE clusters among K. pneumoniae K2 isolates was more diverse than K1 isolates. K1 and K2 HMKP isolates had respective specific profiles of virulence-associated genes.
86 citations
Authors
Showing all 4916 results
Name | H-index | Papers | Citations |
---|---|---|---|
Dorret I. Boomsma | 176 | 1507 | 136353 |
Brenda W.J.H. Penninx | 170 | 1139 | 119082 |
Michael Snyder | 169 | 840 | 130225 |
Lex M. Bouter | 158 | 767 | 103034 |
David Eisenberg | 156 | 697 | 112460 |
Philip Scheltens | 140 | 1175 | 107312 |
Pim Cuijpers | 136 | 982 | 69370 |
Gonneke Willemsen | 129 | 575 | 76976 |
Britton Chance | 128 | 1112 | 76591 |
Coen D.A. Stehouwer | 122 | 970 | 59701 |
Peter J. Anderson | 120 | 966 | 63635 |
Jouke-Jan Hottenga | 120 | 389 | 63039 |
Eco J. C. de Geus | 119 | 522 | 61085 |
Johannes Brug | 109 | 620 | 44832 |
Paul Lips | 109 | 491 | 50403 |