Institution
Public Health Research Institute
Healthcare•
About: Public Health Research Institute is a based out in . It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 4889 authors who have published 8149 publications receiving 276945 citations.
Papers published on a yearly basis
Papers
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TL;DR: A tool that enables researchers with and without thorough knowledge on measurement properties to assess the quality of a study on reliability and measurement error of outcome measurement instruments is developed.
Abstract: Scores on an outcome measurement instrument depend on the type and settings of the instrument used, how instructions are given to patients, how professionals administer and score the instrument, etc. The impact of all these sources of variation on scores can be assessed in studies on reliability and measurement error, if properly designed and analyzed. The aim of this study was to develop standards to assess the quality of studies on reliability and measurement error of clinician-reported outcome measurement instruments, performance-based outcome measurement instrument, and laboratory values. We conducted a 3-round Delphi study involving 52 panelists. Consensus was reached on how a comprehensive research question can be deduced from the design of a reliability study to determine how the results of a study inform us about the quality of the outcome measurement instrument at issue. Consensus was reached on components of outcome measurement instruments, i.e. the potential sources of variation. Next, we reached consensus on standards on design requirements (n = 5), standards on preferred statistical methods for reliability (n = 3) and measurement error (n = 2), and their ratings on a four-point scale. There was one term for a component and one rating of one standard on which no consensus was reached, and therefore required a decision by the steering committee. We developed a tool that enables researchers with and without thorough knowledge on measurement properties to assess the quality of a study on reliability and measurement error of outcome measurement instruments.
148 citations
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TL;DR: Prokaryotic transposable elements are classified as simple IS elements, more complex Tn transposons and self-replicating episomes.
148 citations
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TL;DR: It is shown that ComEC contains an intramolecular disulphide bond in its N‐terminal extracellular loop (between the residues C131 and C172), which is required for the stability of the protein, and is probably introduced by BdbDC, a pair of competence‐induced oxidoreductase proteins.
Abstract: ComEC is a putative channel protein for DNA uptake in Bacillus subtilis and other genetically transformable bacteria. Membrane topology studies suggest a model of ComEC as a multispanning membrane protein with seven transmembrane segments (TMSs), and possibly with one laterally inserted amphipathic helix. We show that ComEC contains an intramolecular disulphide bond in its N-terminal extracellular loop (between the residues C131 and C172), which is required for the stability of the protein, and is probably introduced by BdbDC, a pair of competence-induced oxidoreductase proteins. By in vitro cross-linking using native cysteine residues we show that ComEC forms an oligomer. The oligomerization surface includes a transmembrane segment, TMS-G, near the cytoplasmic C-terminus of ComEC.
147 citations
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TL;DR: The means of adaptation is described, together with some data illustrative of the precision which can be expected, of the Beckman spectrophotometer on the scale of 50 c.mm.
147 citations
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TL;DR: Evidence is presented suggesting that progeny genomes are bound to site(s) possessing the fine structure of viral inclusions or factories, it appears that both the synthesis of single- and double-stranded viral RNA and the morphogenesis of progeny virus particles occur in such factories.
Abstract: Reovirus type 3 is phagocytized by L cells and rapidly sequestered inside lysosomes. Hydrolases within these organelles are capable of stripping the viral coat proteins, but they fail to degrade the double-stranded RNA genome. These observations support the view that sojourn of reovirus in lysosomes, when the lytic enzymes uncoat its genome, is an obligatory step in the sequence of infection. Although the mechanism for transferring the uncoated RNA out of lysosomes remains to be elucidated, evidence is presented suggesting that progeny genomes are bound to site(s) possessing the fine structure of viral inclusions or factories. It appears that both the synthesis of single- and double-stranded viral RNA and the morphogenesis of progeny virus particles occur in such factories.
147 citations
Authors
Showing all 4916 results
Name | H-index | Papers | Citations |
---|---|---|---|
Dorret I. Boomsma | 176 | 1507 | 136353 |
Brenda W.J.H. Penninx | 170 | 1139 | 119082 |
Michael Snyder | 169 | 840 | 130225 |
Lex M. Bouter | 158 | 767 | 103034 |
David Eisenberg | 156 | 697 | 112460 |
Philip Scheltens | 140 | 1175 | 107312 |
Pim Cuijpers | 136 | 982 | 69370 |
Gonneke Willemsen | 129 | 575 | 76976 |
Britton Chance | 128 | 1112 | 76591 |
Coen D.A. Stehouwer | 122 | 970 | 59701 |
Peter J. Anderson | 120 | 966 | 63635 |
Jouke-Jan Hottenga | 120 | 389 | 63039 |
Eco J. C. de Geus | 119 | 522 | 61085 |
Johannes Brug | 109 | 620 | 44832 |
Paul Lips | 109 | 491 | 50403 |