Institution
Public Health Research Institute
Healthcare•
About: Public Health Research Institute is a based out in . It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 4889 authors who have published 8149 publications receiving 276945 citations.
Papers published on a yearly basis
Papers
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TL;DR: A specific and sensitive nucleic acid amplification assay that is suitable for routine gene detection and provides quantitative results over a wide range of target concentrations and employs a universal format that can detect any infectious agent.
Abstract: We have developed a specific and sensitive nucleic acid amplification assay that is suitable for routine gene detection. The assay is based on a novel molecular genetic strategy in which two different RNA probes are hybridized to adjacent positions on a target nucleic acid and then ligated to form an amplifiable reporter RNA. The reporter RNA is then replicated up to a hundred billion-fold in a 30-min isothermal reaction that signals the presence of the target. The assay can detect fewer than 100 nucleic acid molecules; it provides quantitative results over a wide range of target concentrations and it employs a universal format that can detect any infectious agent.
88 citations
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University College London1, University of Helsinki2, Katholieke Universiteit Leuven3, Public Health Research Institute4, Maastricht University5, Vrije Universiteit Brussel6, Sahlgrenska University Hospital7, Ghent University8, Synlab Group9, Helsinki University Central Hospital10, University of Strasbourg11, Charles University in Prague12
TL;DR: The resulting paper represents a consensus of both professional societies involved and addresses issues related to cross-generational epigenetic inheritance following IVF and germline genome editing.
Abstract: Two leading European professional societies, the European Society of Human Genetics and the European Society for Human Reproduction and Embryology, have worked together since 2004 to evaluate the impact of fast research advances at the interface of assisted reproduction and genetics, including their application into clinical practice. In September 2016, the expert panel met for the third time. The topics discussed highlighted important issues covering the impacts of expanded carrier screening, direct-to-consumer genetic testing, voiding of the presumed anonymity of gamete donors by advanced genetic testing, advances in the research of genetic causes underlying male and female infertility, utilisation of massively parallel sequencing in preimplantation genetic testing and non-invasive prenatal screening, mitochondrial replacement in human oocytes, and additionally, issues related to cross-generational epigenetic inheritance following IVF and germline genome editing. The resulting paper represents a consensus of both professional societies involved.
88 citations
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88 citations
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TL;DR: The currently available component studies do not have the statistical power nor the quality to draw any meaningful conclusion about key ingredients of psychotherapies for adult depression.
Abstract: Objectives: A recent report from the US Institute of Medicine indicated that identifying core elements of psychosocial interventions is a key step in successfully bringing evidence-based psychosoci...
88 citations
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23 May 1994TL;DR: In this article, a method of sorting mixtures of nucleic acid strands comprising hybridizing the strands to an array of immobilized oligonucleotides, each of which includes a constant segment adjacent to a variable segment, was proposed.
Abstract: A method of sorting mixtures of nucleic acid strands comprising hybridizing the strands to an array of immobilized oligonucleotides, each of which includes a constant segment adjacent to a variable segment. The constant segment of the immobilized oligonucleotides can be made complementary to the ends of strands obtained by digesting a double-stranded nucleic acid with a restriction enzyme and restoring the restriction sites, thereby permitting the sorting of strands according to their variable sequences adjacent to their constant terminal restored restriction sites.
88 citations
Authors
Showing all 4916 results
Name | H-index | Papers | Citations |
---|---|---|---|
Dorret I. Boomsma | 176 | 1507 | 136353 |
Brenda W.J.H. Penninx | 170 | 1139 | 119082 |
Michael Snyder | 169 | 840 | 130225 |
Lex M. Bouter | 158 | 767 | 103034 |
David Eisenberg | 156 | 697 | 112460 |
Philip Scheltens | 140 | 1175 | 107312 |
Pim Cuijpers | 136 | 982 | 69370 |
Gonneke Willemsen | 129 | 575 | 76976 |
Britton Chance | 128 | 1112 | 76591 |
Coen D.A. Stehouwer | 122 | 970 | 59701 |
Peter J. Anderson | 120 | 966 | 63635 |
Jouke-Jan Hottenga | 120 | 389 | 63039 |
Eco J. C. de Geus | 119 | 522 | 61085 |
Johannes Brug | 109 | 620 | 44832 |
Paul Lips | 109 | 491 | 50403 |