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Public Health Research Institute
Healthcare•
About: Public Health Research Institute is a based out in . It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 4889 authors who have published 8149 publications receiving 276945 citations.
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TL;DR: Each elementary step of transcription involves translocation of the 3' terminus of RNA in the RNA polymerase active center, followed by the entry of a nucleoside triphosphate, and the structural basis of these transitions was studied using RNA-protein crosslinks.
83 citations
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TL;DR: This study investigates the protective role of breastfeeding in allergy and atopic disease aetiology in newborns using data from eight studies conducted over a 12-month period from 1997 to 2002.
Abstract: Background Conflicting evidence exists concerning the protective role of breastfeeding in allergy and atopic disease aetiology. Breast milk contains biologically active molecules influencing the innate immune system of newborns. Objective We aim to assess whether cytokines (TGF-beta1, IL-10 and IL-12) and soluble CD14 (sCD14) in breast milk are influenced by maternal atopic constitution and modify the development of atopic manifestations in infants. Methods Milk samples were collected at 1 month post-partum of 315 lactating mothers participating in the ongoing KOALA Birth Cohort Study. The cytokines and sCD14 were analysed by ELISA in the aqueous fraction. We compared the concentrations of cytokines and sCD14 in breast milk between mothers with and without an allergic history and also with and without allergic sensitization (specific IgE). Associations of cytokines and sCD14 with the development of eczema, wheezing in the first 2 years of life and allergic sensitization of infants at the age of 2 years were analysed by multivariate logistic regression analyses to correct for confounders. Results We found higher sCD14 levels in mothers with a positive vs. negative allergic history (7.6 vs. 7.0 microg/mL; P = 0.04) and in mothers who were sensitized vs. non-sensitized (7.8 vs. 7.1 microg/mL; P = 0.03). None of the studied immune factors were associated with infant's atopic outcomes. IL-10 was not detected above the detection limit of 0.2 pg/mL. Conclusion Taking together the results of the present and previous studies, we conclude that there is no convincing evidence for a relation between TGF-beta1, sCD14, IL-10 or IL-12 in breast milk and atopic manifestations in infants.
83 citations
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TL;DR: When protein synthesis is inhibited by the growth of cells in the presence of chloramphenicol, isolated membranes have a 15 to 30% higher lipid content than that of normal cells, and the regulation of membrane composition is discussed.
83 citations
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TL;DR: Diet quality is poorer in persons with depressive and anxiety disorders; in particular in those with comorbidity; the more severe the symptoms, the poorer the diet quality.
83 citations
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TL;DR: The negative effect of various risk factors on cognitive decline decreases with higher age, and a combination of epidemiological factors, such as the selection towards healthier subjects during follow-up, but also risk factor specific features, explain this diminished association at higher age.
Abstract: Risk factors for cognitive decline might depend on chronological age. The aim of the study was to explore the age dependency of risk factors for cognitive decline in cognitively healthy subjects aged 55–85 years at baseline. We included 2527 cognitively healthy subjects from the Longitudinal Aging Study Amsterdam (LASA). Median follow-up was 9.1 (IQR: 3.2–19.0) years. The association of genetic and cardiovascular risk factors, depressive symptoms, inflammation markers and lifestyle risk factors with decline in MMSE and memory function was tested using spline regression analyses. Subjects were on average 70.1 (SD 8.8) years old at baseline. Based on a spline regression model, we divided our sample in three age groups: ≤70 years (young-old), > 70–80 years (old) and > 80 years (oldest-old). The association of LDL cholesterol, homocysteine, hypertension, history of stroke, depressive symptoms, interleukin-6, a1-antichymotrypsin, alcohol use and smoking with cognitive decline significantly differed between the age groups. In general, the presence of these risk factors was associated with less cognitive decline in the oldest-old group compared to the young-old and old group. The negative effect of various risk factors on cognitive decline decreases with higher age. A combination of epidemiological factors, such as the selection towards healthier subjects during follow-up, but also risk factor specific features, for example ensuring the cerebral blood flow in case of hypertension, explain this diminished association at higher age. It is important to take these age differences into account when applying preventive strategies to avert cognitive decline.
82 citations
Authors
Showing all 4916 results
Name | H-index | Papers | Citations |
---|---|---|---|
Dorret I. Boomsma | 176 | 1507 | 136353 |
Brenda W.J.H. Penninx | 170 | 1139 | 119082 |
Michael Snyder | 169 | 840 | 130225 |
Lex M. Bouter | 158 | 767 | 103034 |
David Eisenberg | 156 | 697 | 112460 |
Philip Scheltens | 140 | 1175 | 107312 |
Pim Cuijpers | 136 | 982 | 69370 |
Gonneke Willemsen | 129 | 575 | 76976 |
Britton Chance | 128 | 1112 | 76591 |
Coen D.A. Stehouwer | 122 | 970 | 59701 |
Peter J. Anderson | 120 | 966 | 63635 |
Jouke-Jan Hottenga | 120 | 389 | 63039 |
Eco J. C. de Geus | 119 | 522 | 61085 |
Johannes Brug | 109 | 620 | 44832 |
Paul Lips | 109 | 491 | 50403 |