Journal ArticleDOI
Updated 2016 EAU Guidelines on Muscle-invasive and Metastatic Bladder Cancer
J. Alfred Witjes,Thierry Lebret,Eva Comperat,Nigel C. Cowan,Maria De Santis,Harman Maxim Bruins,Virginia Hernández,Estefania Linares Espinós,James Dunn,Mathieu Rouanne,Yann Neuzillet,Erik Veskimäe,Antoine G. van der Heijden,Georgios Gakis,Maria J. Ribal +14 more
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TLDR
The current summary of the EAU Muscle- invasive and Metastatic Bladder Cancer Guidelines provides an up-to-date overview of the available literature and evidence dealing with diagnosis, treatment, and follow-up of patients with metastatic and muscle-invasive bladder cancer.About:
This article is published in European Urology.The article was published on 2017-03-01. It has received 1209 citations till now. The article focuses on the topics: Bladder cancer & Cystectomy.read more
Citations
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Journal ArticleDOI
European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2020 Guidelines
J. Alfred Witjes,H.M. Bruins,Richard Cathomas,Eva Compérat,Nigel C. Cowan,Georgios Gakis,Virginia Hernández,Estefania Linares Espinós,Anja Lorch,Yann Neuzillet,Mathieu Rouanne,George N. Thalmann,Erik Veskimäe,Maria J. Ribal,Antoine G. van der Heijden +14 more
TL;DR: The results of a collaborative multistakeholder consensus project on advanced bladder cancer (BC) have been incorporated in the 2020 guidelines, addressing those areas where it is unlikely that prospective comparative studies will be conducted.
Journal ArticleDOI
Pembrolizumab as neoadjuvant therapy before radical cystectomy in patients with muscle-invasive urothelial bladder carcinoma (PURE-01): An open-label, single-arm, phase II study
Andrea Necchi,Andrea Anichini,Daniele Raggi,Alberto Briganti,Simona Massa,Roberta Lucianò,Maurizio Colecchia,Patrizia Giannatempo,Roberta Mortarini,Marco Bianchi,Elena Farè,Francesco Monopoli,Renzo Colombo,Andrea Gallina,Andrea Salonia,Antonella Messina,Siraj M. Ali,Russell Madison,Jeffrey S. Ross,Jon Chung,Roberto Salvioni,Luigi Mariani,Francesco Montorsi +22 more
TL;DR: It is indicated that pembrolizumab could be a worthwhile neoadjuvant therapy for the treatment of MIBC when limited to patients with PD-L1-positive or high-TMB tumors.
Journal ArticleDOI
CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells.
Yawei Li,Fuxin Zheng,Xingyuan Xiao,Fei Xie,Dan Tao,Chao Huang,Dong Liu,Miao Wang,Liang Wang,Fuqing Zeng,Guosong Jiang +10 more
TL;DR: It is shown that circHIPK3, also named bladder cancer‐related circular RNA‐2 (BCRC‐2), is significantly down‐regulated in bladder cancer tissues and cell lines, and negatively correlates with bladder cancer grade, invasion as well as lymph node metastasis, respectively.
Journal ArticleDOI
Multiparametric Magnetic Resonance Imaging for Bladder Cancer: Development of VI-RADS (Vesical Imaging-Reporting And Data System).
Valeria Panebianco,Yoshifumi Narumi,Ersan Altun,Bernard H. Bochner,Jason A. Efstathiou,Shaista Hafeez,Shaista Hafeez,Robert Huddart,Robert Huddart,Steve Kennish,Seth P. Lerner,Rodolfo Montironi,Valdair Francisco Muglia,Georg Salomon,Stephen H. Thomas,Hebert Alberto Vargas,J. Alfred Witjes,Mitsuru Takeuchi,Jelle O. Barentsz,James W.F. Catto +19 more
TL;DR: A standardized approach to imaging and reporting mpMRI for BC is defined, by developing a VI-RADS score, derived using T2- Weighted MRI, diffusion-weighted imaging, and dynamic contrast enhancement, which suggests the risks of muscle invasion.
Journal ArticleDOI
Adjuvant Nivolumab versus Placebo in Muscle-Invasive Urothelial Carcinoma.
Dean F Bajorin,J. Alfred Witjes,Jürgen E. Gschwend,Michael Schenker,Begoña P. Valderrama,Yoshihiko Tomita,Aristotelis Bamias,T. Lebret,Shahrokh F. Shariat,Se Hoon Park,Dingwei Ye,Mads Agerbaek,Deborah Enting,Ray McDermott,Pablo Gajate,Avivit Peer,Matthew I. Milowsky,Alexander Nosov,João Neif Antonio,Krzysztof Tupikowski,Laurence Toms,Bruce S. Fischer,Anila Qureshi,Sandra Collette,Keziban Unsal-Kacmaz,Edward Broughton,Dimitrios Zardavas,Henry B. Koon,Matthew D. Galsky +28 more
TL;DR: In this article, the role of adjuvant treatment in high-risk muscle-invasive urothelial carcinoma after radical surgery was not clear, and a phase 3, multicenter, double-blind, randomized, controlled trial was conducted.
References
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Journal ArticleDOI
Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012
J. Ferlay,Eva Steliarova-Foucher,Joannie Lortet-Tieulent,Sonia Rosso,Jan Willem Coebergh,Harry Comber,David Forman,Freddie Bray +7 more
TL;DR: Up-to-date estimates of the cancer burden in Europe alongside the description of the varying distribution of common cancers at both the regional and country level provide a basis for establishing priorities to cancer control actions in Europe.
Journal ArticleDOI
Radical Cystectomy in the Treatment of Invasive Bladder Cancer: Long-Term Results in 1,054 Patients
John P. Stein,Gary Lieskovsky,Richard J. Cote,Susan Groshen,An-Chen Feng,Stuart D. Boyd,Eila C. Skinner,Bernard H. Bochner,Duriayai Thangathurai,Maged Mikhail,Derek Raghavan,Donald G. Skinner +11 more
TL;DR: These data from a large group of patients support the aggressive surgical management of invasive bladder cancer and suggest excellent long-term survival can be achieved with a low incidence of pelvic recurrence.
Journal ArticleDOI
Epidemiology and risk factors of urothelial bladder cancer
Maximilian Burger,James W.F. Catto,Guido Dalbagni,H. Barton Grossman,Harry W. Herr,Pierre I. Karakiewicz,Wassim Kassouf,Lambertus A. Kiemeney,Carlo La Vecchia,Shahrokh F. Shariat,Yair Lotan +10 more
TL;DR: UBC is a frequently occurring malignancy with a significant impact on public health and will remain so because of the high prevalence of smoking and the importance of primary prevention must be stressed and smoking cessation programs need to be encouraged and supported.
Journal ArticleDOI
Long-Term Survival Results of a Randomized Trial Comparing Gemcitabine Plus Cisplatin, With Methotrexate, Vinblastine, Doxorubicin, Plus Cisplatin in Patients With Bladder Cancer
Hans von der Maase,Lisa Sengeløv,J. T. Roberts,Sergio Ricci,Luigi Dogliotti,Tim Oliver,Malcolm J. Moore,Annamaria Zimmermann,M. Arning +8 more
TL;DR: Compared with a large randomized phase III study of GC versus MVAC, long-term survival in patients with locally advanced or metastatic transitional cell carcinoma of the urothelium treated with gemcitabine/cisplatin or methotrexate/vinblastine/doxorubicin/c isplatin was similar in both arms.
Journal ArticleDOI
Identification of Distinct Basal and Luminal Subtypes of Muscle-Invasive Bladder Cancer with Different Sensitivities to Frontline Chemotherapy
Woonyoung Choi,Sima P. Porten,Seungchan Kim,Daniel L. Willis,Elizabeth R. Plimack,Jean H. Hoffman-Censits,Beat Roth,Tiewei Cheng,Mai Tran,Mai Tran,I-Ling Lee,Jonathan Melquist,Jolanta Bondaruk,Tadeusz Majewski,Shizhen Zhang,Shanna Pretzsch,Keith A. Baggerly,Arlene O. Siefker-Radtke,Bogdan Czerniak,Colin P.N. Dinney,David J. McConkey,David J. McConkey +21 more
TL;DR: P53-like MIBCs were consistently resistant to neoadjuvant methotrexate, vinblastine, doxorubicin and cisplatin chemotherapy, and all chemoresistant tumors adopted a p53- like phenotype after therapy.
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