Institution
Rhône-Poulenc
About: Rhône-Poulenc is a based out in . It is known for research contribution in the topics: Alkyl & Catalysis. The organization has 8909 authors who have published 8934 publications receiving 182241 citations. The organization is also known as: Rhone-Poulenc.
Topics: Alkyl, Catalysis, Alkoxy group, Aqueous solution, Receptor
Papers published on a yearly basis
Papers
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TL;DR: In this paper, simple and more powerful modifications of Simes' type procedure for general problems of Logically Related Hypotheses (LRH) are given, and the various modifications are demonstrated and their superiority over existing procedures is indicated.
71 citations
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TL;DR: In this paper, the dispersion of alumina-coated TiO2 particles by adsorption of the sodium salt of poly(acrylic) acid (PANa) was investigated in regard to the effective charge number of the particles.
71 citations
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TL;DR: The link between the degree of nigral degeneration and the sequential activation of dopaminergic compensatory mechanisms in the nigrostriatal pathway is explored and a rethink of the paradigm applied to these mechanisms is proposed.
Abstract: Although several adaptive mechanisms have been identified that mask the existence of Parkinson's disease and delay the onset and aggravation of motor symptoms, the timescale and implications of this compensatory process remain an enigma. In order to examine: (i) the nature of the dopaminergic adaptive mechanisms that come into action; (ii) their sequential activation in relation to the severity of degeneration; and (iii) their efficacy with regard to the maintenance of a normal level of basal ganglia activity, we analysed the brains of mice treated daily with 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine (MPTP, 4 mg/kg, i.p.) and killed at 5-day intervals from day 0 (D0) to D20. Our results demonstrate the sequential activation of two compensatory mechanisms: (i) an increase in striatal tyrosine hydroxylase (TH) protein content attested by the persistence of TH immunolabelling up to D15, contrasting with the decrease observed in both the number of nigral TH-immunoreactive neurons (-70.2%) and striatal dopamine content (-38.4%); (ii) a downregulation of DA uptake in surviving terminals at D20 (73.4% of nigral degeneration). At this point, the failure of adaptive mechanisms to maintain striatal dopaminergic homeostasis is also illustrated by an increase in the cytochrome oxidase activity of substantia nigra pars reticulata, a marker of neuronal function. It has been postulated that an increase in dopamine release per pulse could constitute an adaptive mechanism. The data we present from our MPTP mice model infirm this hypothesis. This study explores the link between the degree of nigral degeneration and the sequential activation of dopaminergic compensatory mechanisms in the nigrostriatal pathway and, in so doing, proposes a rethink of the paradigm applied to these mechanisms.
70 citations
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TL;DR: Pepticinnamins A, B, C, D, E and F, a family of farnesyl-protein transferase (FPT) inhibitors were isolated from the fermentation broth of Streptomyces sp.
Abstract: Pepticinnamins A, B, C, D, E and F, a family of farnesyl-protein transferase (FPT) inhibitors were isolated from the fermentation broth of Streptomyces sp OH-4652 These inhibitors were purified from whole broth by extraction with chloroform, followed by silica gel column chromatography, Sephadex LH-20 chromatography and reverse phase HPLC Among these, pepticinnamin C showed the most potent inhibition (IC50-100 nM)
70 citations
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20 Nov 1991TL;DR: In this paper, an inorganic fiber matrix consisting of at least one inorganic filler material, e.g., a mineral wool and/or kaolin, and a consolidating of a binder therefor which comprises admixture of a xanthan gum and a cationic starch.
Abstract: Physically/mechanically improved insulating shaped articles such as panels or plates, adapted to withstand very elevated temperatures, comprise an inorganic fiber matrix, e.g., a matrix of ceramic fibers, such inorganic fiber matrix containing at least one inorganic filler material, e.g., a mineral wool and/or kaolin, and a consolidating of a binder therefor which comprises admixture of a xanthan gum and a cationic starch.
70 citations
Authors
Showing all 8909 results
Name | H-index | Papers | Citations |
---|---|---|---|
Bart Staels | 152 | 824 | 86638 |
Joseph Schlessinger | 150 | 492 | 98862 |
Jean-Marie Lehn | 123 | 1054 | 84616 |
Angus C. Nairn | 118 | 469 | 44330 |
Allan I. Basbaum | 114 | 355 | 55532 |
Patrick Couvreur | 111 | 678 | 56735 |
Joël Vandekerckhove | 107 | 452 | 38241 |
Jules A. Hoffmann | 106 | 244 | 43596 |
Johan Richard | 95 | 499 | 25915 |
Jacques Mallet | 81 | 408 | 24502 |
Roland Douce | 80 | 284 | 18239 |
David Givol | 80 | 260 | 20057 |
Jean-Antoine Girault | 77 | 246 | 19592 |
Michel Perricaudet | 76 | 296 | 20063 |
Jean-Marie Basset | 75 | 737 | 23390 |