Institution
Rhône-Poulenc
About: Rhône-Poulenc is a based out in . It is known for research contribution in the topics: Alkyl & Catalysis. The organization has 8909 authors who have published 8934 publications receiving 182241 citations. The organization is also known as: Rhone-Poulenc.
Topics: Alkyl, Catalysis, Alkoxy group, Aqueous solution, Receptor
Papers published on a yearly basis
Papers
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TL;DR: This drug is well-tolerated by animals and may be recommended in the prevention of ruminant cryptosporidiosis, a disease which has very limited treatment options.
45 citations
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TL;DR: It is found that after DC treatment rho zero cells could be isolated from all cell lines of mouse or human origin tested, and maintained ability to receive exogenously imported mtDNA and allow its replication and gene expression.
45 citations
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TL;DR: The results indicate that blockade of NK1 receptors induces a decrease in the expression of naloxone-precipitated morphine abstinence in rats, and support the participation of substance P in the opiate withdrawal response.
45 citations
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TL;DR: Although animal cell lines have been established in serum-supplemented medium, LLC-PK1 and OK cells as well as primary cultures of proximal tubules are successfully grown in hormonally defined medium, the standardization of which is better controlled for nephrotoxicity studies.
Abstract: The characteristics of two established renal cell lines (LLC-PKI and OK) and of primary cultures of rabbit and human proximal tubule cells are described by summarizing the literature about speczjic properties retained by these cells in culture. Furthermore, comparative biochemical and functional properties are presented including both specijic marker enzymes and transport properties of these cells grown in various media. 7he impact of culture medium composition on the expressed cellular phenotype is discussed and its consequences on the projile of t o i c response due to aminoglycoside antibiotics is analyzed. The in vitro nephrotoxicity of three platinum-containing coordination complexes which exhibited different in vivo nephrotoxic potentials is studied by another technique in a model of rabbit proximal tubule cells in primary cultures in order to correlate results to in vivo data and to dejne reliable and sensitive parameters for the assessment of platinum-derivativeinduced nephrotoxicity. Although ani...
45 citations
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TL;DR: Detailed study of multifunctional forms of acetyl-CoA carboxylases, which have different sensitivities to herbicides, suggests that herbicide resistance is correlated with cooperativity of herbicide binding to the native dimeric form of the carboxyase.
Abstract: Acetyl-CoA carboxylase catalyses the first committed step in fatty acid (and acyl lipid) formation. The enzyme has been shown to exert a high degree of flux control for lipid biosynthesis in leaves and, therefore, it is not surprising that chemicals which can inhibit it effectively are successful herbicides. These chemicals belong mainly to the cyclohexanedione and aryloxyphenoxypropionate classes and are graminicides. The reason for the selectivity of these herbicides towards grasses lies in the nature of the target site, acetyl-CoA carboxylase. Recent advances in our knowledge of acetyl-CoA carboxylases from sensitive and resistant plants has revealed some important facts. Dicotyledons, which are resistant, have a multi-enzyme complex type of carboxylase in their chloroplasts while grasses have a multifunctional protein. Both divisions of plants have two isoforms of the enzyme, the second being in the cytosol. Detailed study of multifunctional forms of acetyl-CoA carboxylases, which have different sensitivities to herbicides, suggests that herbicide resistance is correlated with cooperativity of herbicide binding to the native dimeric form of the carboxylase.
45 citations
Authors
Showing all 8909 results
Name | H-index | Papers | Citations |
---|---|---|---|
Bart Staels | 152 | 824 | 86638 |
Joseph Schlessinger | 150 | 492 | 98862 |
Jean-Marie Lehn | 123 | 1054 | 84616 |
Angus C. Nairn | 118 | 469 | 44330 |
Allan I. Basbaum | 114 | 355 | 55532 |
Patrick Couvreur | 111 | 678 | 56735 |
Joël Vandekerckhove | 107 | 452 | 38241 |
Jules A. Hoffmann | 106 | 244 | 43596 |
Johan Richard | 95 | 499 | 25915 |
Jacques Mallet | 81 | 408 | 24502 |
Roland Douce | 80 | 284 | 18239 |
David Givol | 80 | 260 | 20057 |
Jean-Antoine Girault | 77 | 246 | 19592 |
Michel Perricaudet | 76 | 296 | 20063 |
Jean-Marie Basset | 75 | 737 | 23390 |