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Institution

Rhône-Poulenc

About: Rhône-Poulenc is a based out in . It is known for research contribution in the topics: Alkyl & Catalysis. The organization has 8909 authors who have published 8934 publications receiving 182241 citations. The organization is also known as: Rhone-Poulenc.


Papers
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Journal ArticleDOI
TL;DR: This drug is well-tolerated by animals and may be recommended in the prevention of ruminant cryptosporidiosis, a disease which has very limited treatment options.

45 citations

Journal ArticleDOI
TL;DR: It is found that after DC treatment rho zero cells could be isolated from all cell lines of mouse or human origin tested, and maintained ability to receive exogenously imported mtDNA and allow its replication and gene expression.

45 citations

Journal ArticleDOI
TL;DR: The results indicate that blockade of NK1 receptors induces a decrease in the expression of naloxone-precipitated morphine abstinence in rats, and support the participation of substance P in the opiate withdrawal response.

45 citations

Journal ArticleDOI
TL;DR: Although animal cell lines have been established in serum-supplemented medium, LLC-PK1 and OK cells as well as primary cultures of proximal tubules are successfully grown in hormonally defined medium, the standardization of which is better controlled for nephrotoxicity studies.
Abstract: The characteristics of two established renal cell lines (LLC-PKI and OK) and of primary cultures of rabbit and human proximal tubule cells are described by summarizing the literature about speczjic properties retained by these cells in culture. Furthermore, comparative biochemical and functional properties are presented including both specijic marker enzymes and transport properties of these cells grown in various media. 7he impact of culture medium composition on the expressed cellular phenotype is discussed and its consequences on the projile of t o i c response due to aminoglycoside antibiotics is analyzed. The in vitro nephrotoxicity of three platinum-containing coordination complexes which exhibited different in vivo nephrotoxic potentials is studied by another technique in a model of rabbit proximal tubule cells in primary cultures in order to correlate results to in vivo data and to dejne reliable and sensitive parameters for the assessment of platinum-derivativeinduced nephrotoxicity. Although ani...

45 citations

Journal ArticleDOI
TL;DR: Detailed study of multifunctional forms of acetyl-CoA carboxylases, which have different sensitivities to herbicides, suggests that herbicide resistance is correlated with cooperativity of herbicide binding to the native dimeric form of the carboxyase.
Abstract: Acetyl-CoA carboxylase catalyses the first committed step in fatty acid (and acyl lipid) formation. The enzyme has been shown to exert a high degree of flux control for lipid biosynthesis in leaves and, therefore, it is not surprising that chemicals which can inhibit it effectively are successful herbicides. These chemicals belong mainly to the cyclohexanedione and aryloxyphenoxypropionate classes and are graminicides. The reason for the selectivity of these herbicides towards grasses lies in the nature of the target site, acetyl-CoA carboxylase. Recent advances in our knowledge of acetyl-CoA carboxylases from sensitive and resistant plants has revealed some important facts. Dicotyledons, which are resistant, have a multi-enzyme complex type of carboxylase in their chloroplasts while grasses have a multifunctional protein. Both divisions of plants have two isoforms of the enzyme, the second being in the cytosol. Detailed study of multifunctional forms of acetyl-CoA carboxylases, which have different sensitivities to herbicides, suggests that herbicide resistance is correlated with cooperativity of herbicide binding to the native dimeric form of the carboxylase.

45 citations


Authors

Showing all 8909 results

NameH-indexPapersCitations
Bart Staels15282486638
Joseph Schlessinger15049298862
Jean-Marie Lehn123105484616
Angus C. Nairn11846944330
Allan I. Basbaum11435555532
Patrick Couvreur11167856735
Joël Vandekerckhove10745238241
Jules A. Hoffmann10624443596
Johan Richard9549925915
Jacques Mallet8140824502
Roland Douce8028418239
David Givol8026020057
Jean-Antoine Girault7724619592
Michel Perricaudet7629620063
Jean-Marie Basset7573723390
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20201
20161
20119
201024
20095
20081