Institution
Rhône-Poulenc
About: Rhône-Poulenc is a based out in . It is known for research contribution in the topics: Alkyl & Catalysis. The organization has 8909 authors who have published 8934 publications receiving 182241 citations. The organization is also known as: Rhone-Poulenc.
Topics: Alkyl, Catalysis, Alkoxy group, Aqueous solution, Receptor
Papers published on a yearly basis
Papers
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TL;DR: In this article, a complete description of adipic crystallization from an aqueous solution is presented, including nucleation, growth and agglomeration, carried out in a semi-batch isothermal crystallizer fed by a hot solution of fat.
55 citations
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TL;DR: The purified angiogenin was demonstrated to be active as an angiogenic factor and exhibited a characteristic RNase activity.
55 citations
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TL;DR: Repeated inhaled doses of ADI628 were safe and generally well tolerated with no apparent systemic immunosuppressive activity in healthy and asthmatic subjects.
Abstract: Severe asthmatics treated with oral/inhaled corticosteroids are at risk of side effects (adrenal suppression). Oral cyclosporin A has been effective in asthma treatment, and nebulized cyclosporin A has been administered for similar to 6 months with no nephrotoxicity or hepatotoxicity, suggesting a wider therapeutic margin for an inhaled cyclosporin A for treatment of asthma. Single- and repeated-dose studies in healthy and asthmatic male and female subjects were conducted to determine the pharmacokinetics, pharmacodynamics, and safety of a new formulation of inhaled cyclosporin A (ADI628) metered-dose inhaler (MDI). ADI628 had roughly dose-linear increases in blood concentrations with moderate variability after single and multiple administration in healthy subjects. Steady-state ADI628 concentrations reflected an effective half-life of 7.0 to 12.5 hours. No overt gender-related differences were observed after single inhaled 10 mg ADI628 dose. However, asthmatics and females (20 mg dose group) had lower ADI628 concentrations as compared to healthy males, probably due to lower inspiratory flow rates and probably not due to disease- or gender-related differences in metabolism/elimination ofADI628. Renal excretion was a minor route of elimination for ADI628 with no dose- or gender-related differences. The blood ADI628 exposure in humans was 1/3- to 1/6-fold lower than the no-effect dose in dogs. Also, the blood ADI628 exposure after the highest inhaled dose was much lower than after the administration of the efficacious oral cyclosporin A dose (3 mg/kg) for treating asthma. The highest steady-state dose (10 mg bid) resulted in ADI628 concentrations that are not typically associated with systemic nephrotoxicity or immunosuppression. furthermore, repeated inhaled doses of ADI628 were safe and generally well tolerated with no apparent systemic immunosuppressive activity in healthy and asthmatic subjects. (C)2000 the American College of Clinical Pharmacology.
55 citations
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TL;DR: The CR3 cell line did not spontaneously express the specific blood-brain barrier markers gamma-glutamyl transpeptidase and mdr P-glycoprotein, but when the cells were treated with the cell differentiating agent all-trans-retinoic acid, the blood- brain barrier markers were induced.
54 citations
Authors
Showing all 8909 results
Name | H-index | Papers | Citations |
---|---|---|---|
Bart Staels | 152 | 824 | 86638 |
Joseph Schlessinger | 150 | 492 | 98862 |
Jean-Marie Lehn | 123 | 1054 | 84616 |
Angus C. Nairn | 118 | 469 | 44330 |
Allan I. Basbaum | 114 | 355 | 55532 |
Patrick Couvreur | 111 | 678 | 56735 |
Joël Vandekerckhove | 107 | 452 | 38241 |
Jules A. Hoffmann | 106 | 244 | 43596 |
Johan Richard | 95 | 499 | 25915 |
Jacques Mallet | 81 | 408 | 24502 |
Roland Douce | 80 | 284 | 18239 |
David Givol | 80 | 260 | 20057 |
Jean-Antoine Girault | 77 | 246 | 19592 |
Michel Perricaudet | 76 | 296 | 20063 |
Jean-Marie Basset | 75 | 737 | 23390 |