Rhône-Poulenc

About: Rhône-Poulenc is a based out in . It is known for research contribution in the topics: Alkyl & Catalysis. The organization has 8909 authors who have published 8934 publications receiving 182241 citations. The organization is also known as: Rhone-Poulenc.

Onium borates/borates of organometallic complexes and cationic initiation of polymerization therewith

Abstract: Novel onium borates of an element of Groups 15 to 17 of the Periodic Table, or borates of an organometallic complex of an element of Groups 4 to 10 of the Periodic Table, well suited for the photochemical/electron beam cationic initiation of polymerization/crosslinking, the anionic borate moiety of which having the formula: [BX.sub.a R.sub.b ].sup.- in which a and b are integers ranging from 0 to 4 and a+b=4; the symbols X are each a halogen atom when a ranges up to 3 and an OH functional group when a ranges up to 2; and the symbols R, which may be identical or different, are each a phenyl radical substituted by at least one element or electron-withdrawing substituent or by at least two halogen atoms, or an aryl radical containing at least two aromatic ring members, or such aryl radical bearing at least one electron-withdrawing substituent.

Changes in clinical pathology parameters during gestation in the New Zealand white rabbit.

Abstract: Hematology and serum chemistry parameters were analyzed in 2 groups of pregnant rabbits to assess changes in these parameters over the course of gestation. These data were used to generate a histor...

Response of human tumor xenografts in athymic nude mice to docetaxel (RP 56976, Taxotere®)

Abstract: Docetaxel (Taxotere®, RP 56976, NSC 628503), a new taxoid, was evaluated for preclinical evidence of anticancer activity in athymic nude (NCr-nu) mice bearing established, subcutaneously (s.c.) implanted human tumor xenografts CX-1 or KM20L2 (colon carcinomas), LX-1 (lung carcinoma), MX-1 (mammary carcinoma), and SK-MEL-2 (melanoma). Other evaluations used OVCAR-3 (ovarian carcinoma) xenografts implanted intraperitoneally (i.p.). Docetaxel was administered intravenously (i.v.) every 4 days for 3 injections (q4d×3) except for one OVCAR-3 experiment in which the drug was given i.p. every 7 days for 3 injections. Tumor measurements, animal body weights, and mortality were determined. The highest dosage used (50 mg/kg/dose) was toxic in all experiments in which the 4-day treatment interval was used. The maximally tolerated dosage (MTD) ranged from 15 to 33 mg/kg/dose. Therapeutic responses among these xenografts ranged from clinically important long-term tumor-free survivors (MX-1, SK-MEL-2, and OVCAR-3) to tumor growth delays of various durations (CX-1, LX-1, and KM20L2). The response of SKMEL-2, a xenograft highly refractory to available drugs, was particularly noteworthy. These results are indicative of a broad spectrum of antitumor activity for docetaxel.

Partition-based selection

Abstract: This article concentrates on diversity-related methods in which the analysis involves a partitioning into discrete cells of compounds or data derived from compounds. A detailed discussion is given of two major approaches. In the first approach, each compound is assigned to only one cell, and two methods that use partitioning by molecular/atomic properties are described (DPD; BCUT/DiverseSolutions). In the second approach, each compound may exhibit multiple values of the property being partitioned, particularly when conformational flexibility is taken into account, and therefore may belong to many partitions; two methods that use potential three-dimensional pharmacophores as a molecular similarity/diversity measure are described (PDQ and ChemDiverse). The use of these methods for database analysis, subset selection and combinatorial library design is discussed.