Shandong University

About: Shandong University is a education organization based out in Jinan, Shandong, China. It is known for research contribution in the topics: Laser & Cancer. The organization has 99070 authors who have published 99160 publications receiving 1625094 citations. The organization is also known as: Shāndōng Dàxué.

Mechanism of substrate recognition and transport by an amino acid antiporter

Abstract: In extremely acidic environments, enteric bacteria such as Escherichia coli rely on the amino acid antiporter AdiC to expel protons by exchanging intracellular agmatine (Agm(2+)) for extracellular arginine (Arg(+)). AdiC is a representative member of the amino acid-polyamine-organocation (APC) superfamily of membrane transporters. The structure of substrate-free AdiC revealed a homodimeric assembly, with each protomer containing 12 transmembrane segments and existing in an outward-open conformation. The overall folding of AdiC is similar to that of the Na(+)-coupled symporters. Despite these advances, it remains unclear how the substrate (arginine or agmatine) is recognized and transported by AdiC. Here we report the crystal structure of an E. coli AdiC variant bound to Arg at 3.0 A resolution. The positively charged Arg is enclosed in an acidic binding chamber, with the head groups of Arg hydrogen-bonded to main chain atoms of AdiC and the aliphatic portion of Arg stacked by hydrophobic side chains of highly conserved residues. Arg binding induces pronounced structural rearrangement in transmembrane helix 6 (TM6) and, to a lesser extent, TM2 and TM10, resulting in an occluded conformation. Structural analysis identified three potential gates, involving four aromatic residues and Glu 208, which may work in concert to differentially regulate the upload and release of Arg and Agm.

Measurement of the W-boson mass in pp collisions at s=7TeV with the ATLAS detector.

Abstract: A measurement of the mass of the $W$ boson is presented based on proton-proton collision data recorded in 2011 at a centre-of-mass energy of 7 TeV with the ATLAS detector at the LHC, and corresponding to 4.6 fb$^{-1}$ of integrated luminosity. The selected data sample consists of $7.8 \times 10^6$ candidates in the $W\rightarrow \mu u$ channel and $5.9 \times 10^6$ candidates in the $W\rightarrow e u$ channel. The $W$-boson mass is obtained from template fits to the reconstructed distributions of the charged lepton transverse momentum and of the $W$ boson transverse mass in the electron and muon decay channels, yielding \begin{eqnarray} m_W &=& 80370 \pm 7 \, (\textrm{stat.}) \pm 11 \, (\textrm{exp. syst.}) \pm 14 \, (\textrm{mod. syst.}) \, \textrm{MeV} &=& 80370 \pm 19 \, \textrm{MeV}, \end{eqnarray} where the first uncertainty is statistical, the second corresponds to the experimental systematic uncertainty, and the third to the physics-modelling systematic uncertainty. A measurement of the mass difference between the $W^+$ and $W^-$ bosons yields $m_{W^+}-m_{W^-} = -29 \pm 28$ MeV.

Facile Synthesis of Hierarchical Mesoporous Honeycomb-like NiO for Aqueous Asymmetric Supercapacitors

Abstract: Three-dimensional (3D) hierarchical nanostructures have been demonstrated as one of the most ideal electrode materials in energy storage systems due to the synergistic combination of the advantages of both nanostructures and microstructures. In this study, the honeycomb-like mesoporous NiO microspheres as promising cathode materials for supercapacitors have been achieved using a hydrothermal reaction, followed by an annealing process. The electrochemical tests demonstrate the highest specific capacitance of 1250 F g–1 at 1 A g–1. Even at 5 A g–1, a specific capacitance of 945 F g–1 with 88.4% retention after 3500 cycles was obtained. In addition, the 3D porous graphene (reduced graphene oxide, rGO) has been prepared as an anode material for supercapacitors, which displays a good capacitance performance of 302 F g–1 at 1 A g–1. An asymmetric supercapacitor has been successfully fabricated based on the honeycomb-like NiO and rGO. The asymmetric supercapacitor achieves a remarkable performance with a specifi...