University of Liverpool

About: University of Liverpool is a education organization based out in Liverpool, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 40406 authors who have published 94388 publications receiving 3188970 citations. The organization is also known as: Liverpool University & The University of Liverpool.

The multifactorial role of neutrophils in rheumatoid arthritis

Abstract: Of all cells implicated in the pathology of rheumatoid arthritis (RA), neutrophils possess the greatest cytotoxic potential, owing to their ability to release degradative enzymes and reactive oxygen species. Neutrophils also contribute to the cytokine and chemokine cascades that accompany inflammation, and regulate immune responses via cell-cell interactions. Emerging evidence suggests that neutrophils also have a previously unrecognised role in autoimmune diseases: neutrophils can release neutrophil extracellular traps (NETs) containing chromatin associated with granule enzymes, which not only kill extracellular microorganisms but also provide a source of autoantigens. For example, citrullinated proteins that can act as neoepitopes in loss of immune tolerance are generated by peptidylarginine deiminases, which replace arginine with citrulline residues, within neutrophils. Indeed, antibodies to citrullinated proteins can be detected before the onset of symptoms in patients with RA, and are predictive of erosive disease. Neutrophils from patients with RA have an increased tendency to form NETs containing citrullinated proteins, and sera from such patients contain autoantibodies that recognize these proteins. Thus, in addition to their cytotoxic and immunoregulatory role in RA, neutrophils may be a source of the autoantigens that drive the autoimmune processes underlying this disease.

Suicides associated with the 2008-10 economic recession in England: time trend analysis

Abstract: Objective To determine whether English regions worst affected by the economic recession in the United Kingdom in 2008-10 have had the greatest increases in suicides. Design Time trend analysis comparing the actual number of suicides with those that would be expected if pre-recession trends had continued. Multivariate regression models quantified the association between changes in unemployment (based on claimant data) and suicides (based on data from the National Clinical Health Outcomes Database). Setting 93 English regions, based on the Nomenclature of Territorial Units Statistics level 3 groupings of local authorities at county level and groups of unitary local authorities. Participants Men and women with a record of death from suicide or injury of undetermined cause in 2000-10. Main outcome measure Number of excess suicides during the economic recession (2008-10). Results Between 2008 and 2010, we found 846 (95% confidence interval 818 to 877) more suicides among men than would have been expected based on historical trends, and 155 (121 to 189) more suicides among women. Historically, short term yearly fluctuations in unemployment have been associated with annual changes in suicides among men but not among women. We estimated that each 10% increase in the number of unemployed men was significantly associated with a 1.4% (0.5% to 2.3%) increase in male suicides. These findings suggest that about two fifths of the recent increase in suicides among men (increase of 329 suicides, 126 to 532) during the 2008-10 recession can be attributed to rising unemployment. Conclusion The study provides evidence linking the recent increase in suicides in England with the financial crisis that began in 2008. English regions with the largest rises in unemployment have had the largest increases in suicides, particularly among men.

Ultrabroadband Elastic Cloaking in Thin Plates

Abstract: Control of waves with metamaterials is of great topical interest, and is fueled by rapid progress in broadband acoustic and electromagnetic cloaks. We propose a design for a cloak to control bending waves propagating in isotropic heterogeneous thin plates. This is achieved through homogenization of a multilayered concentric coating filled with piecewise constant isotropic elastic material. Significantly, our cloak displays no phase shift for both backward and forward scattering. To foster experimental efforts, we provide a simplified design of the cloak which is shown to work in a more than two-octave frequency range (30 Hz to 150 Hz) when it consists of 10 layers using only 6 different materials overall. This metamaterial should be easy to manufacture, with potential applications ranging from car industry to antiearthquake passive systems for smart buildings, depending upon the plate dimensions and wavelengths.

Epilepsy and social identity: the stigma of a chronic neurological disorder.

Abstract: Summary Epilepsy is the most common serious neurological disorder worldwide, affecting about 50 million people. 1 In most people with epilepsy, the disorder is clinically benign. However, because of the stigma associated with having epilepsy, which is common to many cultures, there can be a negative effect on the social identity of people with the disorder, particularly for those living in resource-poor countries. In this paper, we present general theories of stigma, as well as those specific to chronic illness. We relate these theories to the stigma associated with epilepsy throughout history and across cultures. We review research on the relation between stigma and the overall quality of life of people with epilepsy. Finally, we address reduction of the stigma.