Institution
University of Liverpool
Education•Liverpool, United Kingdom•
About: University of Liverpool is a education organization based out in Liverpool, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 40406 authors who have published 94388 publications receiving 3188970 citations. The organization is also known as: Liverpool University & The University of Liverpool.
Papers published on a yearly basis
Papers
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TL;DR: This review aims to provide physicians with an update on the etiology, management, and prognosis of Lemierre's syndrome.
Abstract: Objectives/Hypothesis:
Lemierre's syndrome is characterized by a history of recent oropharyngeal infection, clinical or radiological evidence of internal jugular vein thrombosis, and isolation of anaerobic pathogens, mainly Fusobacterium necrophorum. It was once called the forgotten disease because of its rarity, but it may not be that uncommon after all. This review aims to provide physicians with an update on the etiology, management, and prognosis of Lemierre's syndrome.
Methods:
Systematic review using the terms: Lemierre's syndrome, postanginal septicemia, fusobacterium, internal jugular vein thrombosis. Inclusion criteria: English literature; reviews, case reports, and case series. Exclusion criteria: variants or atypical Lemierre's syndrome cases, negative fusobacteria cultures, and papers without radiological evidence of thrombophlebitis.
Results:
Eighty-four studies fulfilled our inclusion criteria. The male to female ratio was 1:1, 2, and the ages ranged from 2 months to 78 years (median, 22 years). Main sources of infection were tonsil, pharynx, and chest. Most common first clinical presentation was a sore throat, followed by a neck mass and neck pain. The most common offending micro-organism was F. necrophorum. Treatment modalities used were antimicrobial, anticoagulant, and surgical treatment. Morbidity was significant with prolonged hospitalization in the majority of patients. The overall mortality rate was 5%.
Conclusions:
Lemierre's syndrome may not be as rare as previously thought. This apparent increase in the incidence may be due to antibiotic resistance or changes in antibiotic prescription patterns. Successful management rests on the awareness of the condition, a high index of suspicion, and a multidisciplinary team approach. Laryngoscope, 2009
355 citations
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University of Edinburgh1, Fred Hutchinson Cancer Research Center2, University of Southampton3, Katholieke Universiteit Leuven4, University of Oxford5, Broad Institute6, United States Department of the Army7, University of Cambridge8, Technical University of Denmark9, Erasmus University Rotterdam10, Wellcome Trust Sanger Institute11, Bernhard Nocht Institute for Tropical Medicine12, Public Health England13, Pasteur Institute14, University of Sierra Leone15, Harvard University16, University of Liverpool17, University of Makeni18, University of Bristol19, University of Birmingham20, Princeton University21, Centre national de la recherche scientifique22, Louisiana State University23, Scripps Research Institute24, Scripps Health25, World Health Organization26, Chinese Center for Disease Control and Prevention27, University of Sydney28, Imperial College London29, National Institutes of Health30, Centers for Disease Control and Prevention31, University of California, Los Angeles32
TL;DR: It is revealed that this large epidemic was a heterogeneous and spatially dissociated collection of transmission clusters of varying size, duration and connectivity, which will help to inform interventions in future epidemics.
Abstract: The 2013-2016 West African epidemic caused by the Ebola virus was of unprecedented magnitude, duration and impact. Here we reconstruct the dispersal, proliferation and decline of Ebola virus throughout the region by analysing 1,610 Ebola virus genomes, which represent over 5% of the known cases. We test the association of geography, climate and demography with viral movement among administrative regions, inferring a classic 'gravity' model, with intense dispersal between larger and closer populations. Despite attenuation of international dispersal after border closures, cross-border transmission had already sown the seeds for an international epidemic, rendering these measures ineffective at curbing the epidemic. We address why the epidemic did not spread into neighbouring countries, showing that these countries were susceptible to substantial outbreaks but at lower risk of introductions. Finally, we reveal that this large epidemic was a heterogeneous and spatially dissociated collection of transmission clusters of varying size, duration and connectivity. These insights will help to inform interventions in future epidemics.
354 citations
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Carlos III Health Institute1, Radboud University Nijmegen2, Statens Serum Institut3, Hacettepe University4, University of Lausanne5, University of Copenhagen6, Innsbruck Medical University7, Manchester Academic Health Science Centre8, Misericordia University9, University Hospital of Lausanne10, Boston Children's Hospital11, University of Cologne12, University of Strasbourg13, University of Liverpool14, Necker-Enfants Malades Hospital15, Pasteur Institute16, Katholieke Universiteit Leuven17, National and Kapodistrian University of Athens18, University of Genoa19, University of Würzburg20
TL;DR: In this paper, a panel of experts of the European Fungal Infection Study Group (EFISG) undertook a data review and compiled guidelines for the clinical utility and accuracy of different diagnostic tests and procedures for detection of Candida infections.
354 citations
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TL;DR: The hypothesis that the impact of care within the ICU has an impact on subsequent psychological morbidity and therefore must be assessed in future studies looking at the way patients are sedated in theICU and how physical restraint is used is raised.
Abstract: Objective
This prospective observational study was designed to explore the relationships between post-traumatic stress disorder (PTSD), patients' memories of the intensive care unit (ICU) and sedation practices.
354 citations
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TL;DR: The data indicate that these subjects had a functional selenium deficit with suboptimal immune status and a deficit in viral handling, and suggest that the additional 100 microg Se/d may be insufficient to support optimal function.
354 citations
Authors
Showing all 40921 results
Name | H-index | Papers | Citations |
---|---|---|---|
Lei Jiang | 170 | 2244 | 135205 |
Gregory Y.H. Lip | 169 | 3159 | 171742 |
Ian J. Deary | 166 | 1795 | 114161 |
Nicholas J. White | 161 | 1352 | 104539 |
Tomas Hökfelt | 158 | 1033 | 95979 |
William J. Sutherland | 148 | 966 | 94423 |
Tommaso Dorigo | 141 | 1806 | 104276 |
Paul Jackson | 141 | 1372 | 93464 |
Andrew Askew | 140 | 1496 | 99635 |
Stephen Wimpenny | 138 | 1489 | 104084 |
Robin Erbacher | 138 | 1721 | 100252 |
Andrew Mehta | 137 | 1444 | 101810 |
Tim Jones | 135 | 1314 | 91422 |
Christophe Delaere | 135 | 1320 | 96742 |
Sinead Farrington | 133 | 1422 | 91099 |