Institution
University of Minho
Education•Braga, Portugal•
About: University of Minho is a education organization based out in Braga, Portugal. It is known for research contribution in the topics: Context (language use) & Population. The organization has 10585 authors who have published 34736 publications receiving 732436 citations. The organization is also known as: Universidade do Minho & UMinho.
Topics: Context (language use), Population, Computer science, Thin film, Masonry
Papers published on a yearly basis
Papers
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TL;DR: These striking genome dynamics associated with local adaptation and domestication reveal the remarkable plasticity of the S. cerevisiae genome, revealing this species to be an amazing complex of specialized populations.
Abstract: The budding yeast Saccharomyces cerevisiae can be found in the wild and is also frequently associated with humanactivities. Despite recent insights into the phylogeny of this species, much is still unknown about how evolutionary processes related to anthropogenic niches have shaped the genomes and phenotypes of S. cerevisiae.
To address this question, we performed population-level sequencing of 82 S. cerevisiae strains from wine, flor, rum, dairy products, bakeries, and the natural environment (oak trees). These genomic data enabled us to delineate specific genetic groups corresponding to the different ecological niches and revealed high genome content variation across the groups. Most of these strains, compared with the reference genome, possessed additional genetic elements acquired by introgression or horizontal transfer, several of which were population-specific. In addition, several genomic regions in each population showed evidence of nonneutral evolution, as shown by high differentiation, or of selective sweeps including genes with key functions in these environments (e.g., amino acid transport for wine yeast). Linking genetics to lifestyle differences and metabolite traits has enabled us to elucidate the genetic basis of several niche-specific population traits, such as growth on galactose for cheese strains. These data indicate that yeast has been subjected to various divergent selective pressures depending on its niche, requiring the development of customized genomes for better survival in these environments. These striking genome dynamics associated with local adaptation and domestication reveal the remarkable plasticity of the S. cerevisiae genome, revealing this species to be an amazing complex of specialized populations.
171 citations
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TL;DR: Both tolerance to toxicity and biodegradability of oleic acid were improved by acclimatization with lipids or oleate below a threshold concentration, suggesting the possibility of using adsorption-degradation cycles for the treatment of LCFA based effluents.
170 citations
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TL;DR: In this paper, the authors used MRS broth (Man, Rogosa & Sharpe medium for lactobacilli strains) as a culture medium for biosurfactant production.
170 citations
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TL;DR: A review of the principles, mechanisms, photosensitizers, and current applications of photodynamic therapy can be found in this paper, where the future path on the research of new photosensizers with enhanced tumor selectivity, featuring the improvement of PDT effectiveness has also been addressed.
Abstract: Photodynamic therapy (PDT) is a minimally invasive therapeutic modality that has gained great attention in the past years as a new therapy for cancer treatment. PDT uses photosensitizers that, after being excited by light at a specific wavelength, react with the molecular oxygen to create reactive oxygen species in the target tissue, resulting in cell death. Compared to conventional therapeutic modalities, PDT presents greater selectivity against tumor cells, due to the use of photosensitizers that are preferably localized in tumor lesions, and the precise light irradiation of these lesions. This paper presents a review of the principles, mechanisms, photosensitizers, and current applications of PDT. Moreover, the future path on the research of new photosensitizers with enhanced tumor selectivity, featuring the improvement of PDT effectiveness, has also been addressed. Finally, new applications of PDT have been covered.
170 citations
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TL;DR: Modification of the microenvironment of the biomolecule via multipoint covalent attachment onto a solid surface followed by hydrophilic polymer co-immobilization, or physical containment within nanocarriers, are some of the (latest) strategies discussed aiming at full structural and functional stabilization of said biomolecules.
169 citations
Authors
Showing all 10921 results
Name | H-index | Papers | Citations |
---|---|---|---|
A. Gomes | 150 | 1862 | 113951 |
Kazuhiko Hara | 141 | 1956 | 107697 |
Stefano Giagu | 139 | 1651 | 101569 |
Georges Azuelos | 134 | 1294 | 90690 |
Fumihiko Ukegawa | 133 | 1492 | 94465 |
Luis M. Liz-Marzán | 132 | 616 | 61684 |
Francesco Lacava | 130 | 1042 | 79680 |
Jozsef Toth | 130 | 1151 | 86193 |
Monica Verducci | 129 | 896 | 76002 |
Andrea Messina | 128 | 939 | 75409 |
Rostislav Konoplich | 128 | 811 | 73790 |
Michel Vetterli | 128 | 901 | 76064 |
Nuno Filipe Castro | 128 | 960 | 76945 |
Hideki Okawa | 127 | 839 | 73603 |
Nazim Huseynov | 126 | 833 | 72648 |