University of Minho

About: University of Minho is a education organization based out in Braga, Portugal. It is known for research contribution in the topics: Context (language use) & Population. The organization has 10585 authors who have published 34736 publications receiving 732436 citations. The organization is also known as: Universidade do Minho & UMinho.

Eliminating Leakage Currents in Neutral Point Clamped Inverters for Photovoltaic Systems

Abstract: The main contribution of this paper is the proposal of new modulation techniques for three-phase transformerless neutral point clamped inverters to eliminate leakage currents in photovoltaic systems without requiring any modification on the multilevel inverter or any additional hardware. The modulation techniques are capable of reducing the leakage currents in photovoltaic systems by applying three medium vectors or using only two medium vectors and one specific zero vector to compose the reference vector. In addition, to increase the system utilization, the three-phase neutral point clamped inverter can be designed to also provide functions of active filter using the p-q theory. The proposed system provides maximum power point tracking and compensation of current harmonics and reactive power. To validate the simulation models, an experimental three-phase inverter is used to evaluate leakage currents and the dc link voltage control.

Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas

Abstract: Tumour cells are known to be highly glycolytic, thus producing high amounts of lactic acid. Monocarboxylate transporters (MCTs), by promoting the efflux of the accumulating acids, constitute one of the most important mechanisms in the maintenance of tumour intracellular pH. Since data concerning MCT expression in colorectal carcinomas (CRC) are scarce and controversial, the present study aimed to assess the expressions of MCT1, 2, and 4 in a well characterized series of CRC and assess their role in CRC carcinogenesis. CRC samples (126 cases) were analyzed for MCT1, MCT2, and MCT4 immunoexpression and findings correlated with clinico-pathological parameters. Expression of all MCT isoforms in tumour cells was significantly increased when compared to adjacent normal epithelium. Remarkably, there was a significant gain of membrane expression for MCT1 and MCT4 and loss of plasma membrane expression for MCT2 in tumour cells. Plasma membrane expression of MCT1 was directly related to the presence of vascular invasion. This is the larger study on MCT expression in CRC and evaluates for the first time its clinico-pathological significance. The increased expression of these transporters suggests an important role in CRC, which might justify their use, especially MCT1 and MCT4, as targets in CRC drug therapy.