Institution
UPRRP College of Natural Sciences
About: UPRRP College of Natural Sciences is a based out in . It is known for research contribution in the topics: Apoptosis & Population. The organization has 9323 authors who have published 11826 publications receiving 284172 citations.
Topics: Apoptosis, Population, Gene, Oxidative stress, Signal transduction
Papers published on a yearly basis
Papers
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TL;DR: A pyrene derivative chemosensor based on a dipeptide shows a highly sensitive ratiometric response to Ag(I) as well as silver nanoparticles in aqueous solution at physiological pH.
95 citations
TL;DR: Evidence of glutamatergic abnormalities in mood disorders based on postmortem and magnetic resonance spectroscopy studies is presented, and disrupted energy metabolism involving astrocytic dysfunction is proposed as the underlying mechanism linking altered energy metabolism, perturbations in the glutamatorgic system, and pathogenesis of mood disorders.
Abstract: The role of glutamatergic system in the neurobiology of mood disorders draws increasing attention, as disturbance of this system is consistently implicated in mood disorders including major depressive disorder and bipolar disorder. Thus, the glutamate hypothesis of mood disorders is expected to complement and improve the prevailing monoamine hypothesis, and may indicate novel therapeutic targets. Since the contribution of astrocytes is found to be crucial not only in the modulation of the glutamatergic system but also in the maintenance of brain energy metabolism, alterations in the astrocytic function and neuroenergetic environment are suggested as the potential neurobiological underpinnings of mood disorders. In the present review, the evidence of glutamatergic abnormalities in mood disorders based on postmortem and magnetic resonance spectroscopy (MRS) studies is presented, and disrupted energy metabolism involving astrocytic dysfunction is proposed as the underlying mechanism linking altered energy metabolism, perturbations in the glutamatergic system, and pathogenesis of mood disorders.
95 citations
TL;DR: Activation of the c-Abl-PKCδ-Rac1-p38 MAPK pathway in response to ionizing radiation signals conformational changes of Bak and Bax, resulting in mitochondrial activation-mediated apoptotic cell death in human non-small cell lung cancer cells is shown.
95 citations
TL;DR: Melittin possesses an antifungal effect with another mechanism promoting apoptosis, and diagnostic markers of yeast apoptosis including phosphatidylserine externalization, and DNA and nuclear fragmentation are confirmed.
95 citations
TL;DR: It is found that patients treated with clozapine show lower dopamine synthesis capacity than patients who have responded to first-line treatment, which suggests that a different neurobiology may underlie treatment-resistant schizophrenia and that dopamine synthesiscapacity may be a useful biomarker to predict treatment responsiveness.
95 citations
Authors
Showing all 9323 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Hyun-Chul Kim | 176 | 4076 | 183227 |
| Alfred L. Goldberg | 156 | 474 | 88296 |
| Stephen J. O'Brien | 153 | 1062 | 93025 |
| Taeghwan Hyeon | 139 | 563 | 75814 |
| Keiji Tanaka | 129 | 594 | 82885 |
| Csaba Szabó | 123 | 958 | 61791 |
| Young Hee Lee | 122 | 1168 | 61107 |
| Angus C. Nairn | 118 | 469 | 44330 |
| John P. Giesy | 114 | 1162 | 62790 |
| Graham L. Collingridge | 103 | 353 | 51160 |
| Ki-Hyun Kim | 99 | 1911 | 52157 |
| Andrew D. Ellington | 96 | 569 | 43262 |
| Nam-Gyu Park | 94 | 420 | 48648 |
| Steven J. Cooke | 93 | 937 | 34644 |
| Lenore Fahrig | 89 | 246 | 40968 |