Institution
UPRRP College of Natural Sciences
About: UPRRP College of Natural Sciences is a based out in . It is known for research contribution in the topics: Apoptosis & Population. The organization has 9323 authors who have published 11826 publications receiving 284172 citations.
Topics: Apoptosis, Population, Gene, Oxidative stress, Signal transduction
Papers published on a yearly basis
Papers
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TL;DR: The first selective fluorescent chemosensor (PyDPA) for (p)ppGpp, a bacterial and plant alarmone, is developed by using pyrene-excimer fluorescence and shows very good selectivity for ( p)pp Gpp from among other nucleotides in water.
Abstract: We have developed the first selective fluorescent chemosensor (PyDPA) for (p)ppGpp, a bacterial and plant alarmone. By using pyrene-excimer fluorescence, PyDPA shows very good selectivity for (p)ppGpp from among other nucleotides in water. PyDPA was used for the real-time detection of in vitro ppGpp synthesis by bacterial ribosomal complexes.
91 citations
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Broad Institute1, Massachusetts Institute of Technology2, Harvard University3, Ragon Institute of MGH, MIT and Harvard4, Massachusetts Department of Public Health5, Oswaldo Cruz Foundation6, Florida State University College of Arts and Sciences7, Universidad Nacional Autónoma de Honduras8, Redeemer's University9, UPRRP College of Natural Sciences10, Pasteur Institute11, National Institutes of Health12, University of California, Berkeley13, Tufts University14, Colorado State University15, University of Sierra Leone16
TL;DR: This work designs optimal probe sets, with a specified number of oligonucleotides, that achieve full coverage of, and scale well with, known sequence diversity, and applies them to capture viral genomes in complex metagenomic samples.
Abstract: Metagenomic sequencing has the potential to transform microbial detection and characterization, but new tools are needed to improve its sensitivity. Here we present CATCH, a computational method to enhance nucleic acid capture for enrichment of diverse microbial taxa. CATCH designs optimal probe sets, with a specified number of oligonucleotides, that achieve full coverage of, and scale well with, known sequence diversity. We focus on applying CATCH to capture viral genomes in complex metagenomic samples. We design, synthesize, and validate multiple probe sets, including one that targets the whole genomes of the 356 viral species known to infect humans. Capture with these probe sets enriches unique viral content on average 18-fold, allowing us to assemble genomes that could not be recovered without enrichment, and accurately preserves within-sample diversity. We also use these probe sets to recover genomes from the 2018 Lassa fever outbreak in Nigeria and to improve detection of uncharacterized viral infections in human and mosquito samples. The results demonstrate that CATCH enables more sensitive and cost-effective metagenomic sequencing.
91 citations
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TL;DR: This review focuses on the functional organization of the MTL and other neocortical areas in episodic memory and shows that brain stimulation may impact memory through modulating functional networks, carrying future implications of a novel interventional therapy for memory impairment.
Abstract: Understanding human episodic memory in aspects of large-scale brain networks has become one of the central themes in neuroscience over the last decade. Traditionally, episodic memory was regarded as mostly relying on medial temporal lobe (MTL) structures. However, recent studies have suggested involvement of more widely distributed cortical network and the importance of its interactive roles in the memory process. Both direct and indirect neuro-modulations of the memory network have been tried in experimental treatments of memory disorders. In this review, we focus on the functional organization of the MTL and other neocortical areas in episodic memory. Task-related neuroimaging studies together with lesion studies suggested that specific sub-regions of the MTL are responsible for specific components of memory. However, recent studies have emphasized that connectivity within MTL structures and even their network dynamics with other cortical areas are essential in the memory process. Resting-state functional network studies also have revealed that memory function is subserved by not only the MTL system but also a distributed network, particularly the default-mode network (DMN). Furthermore, researchers have begun to investigate memory networks throughout the entire brain not restricted to the specific resting-state network (RSN). Altered patterns of functional connectivity (FC) among distributed brain regions were observed in patients with memory impairments. Recently, studies have shown that brain stimulation may impact memory through modulating functional networks, carrying future implications of a novel interventional therapy for memory impairment.
91 citations
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TL;DR: Results suggest that the C. pruinosa methanol extract suppresses inflammation through suppression of NF-kappaB-dependent inflammatory gene expression, suggesting that this extract may be beneficial for treatment of endotoxin shock or sepsis.
91 citations
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TL;DR: Oral administration of celastrol suppresses ovalbumin-induced airway inflammation, hyperresponsiveness, and tissue remodeling by regulating the imbalance of MMP-2/-9 and TIMP-1/-2 by inflammatory cytokines via MAP kinases/NF-kappaB in inflammatory cells.
90 citations
Authors
Showing all 9323 results
Name | H-index | Papers | Citations |
---|---|---|---|
Hyun-Chul Kim | 176 | 4076 | 183227 |
Alfred L. Goldberg | 156 | 474 | 88296 |
Stephen J. O'Brien | 153 | 1062 | 93025 |
Taeghwan Hyeon | 139 | 563 | 75814 |
Keiji Tanaka | 129 | 594 | 82885 |
Csaba Szabó | 123 | 958 | 61791 |
Young Hee Lee | 122 | 1168 | 61107 |
Angus C. Nairn | 118 | 469 | 44330 |
John P. Giesy | 114 | 1162 | 62790 |
Graham L. Collingridge | 103 | 353 | 51160 |
Ki-Hyun Kim | 99 | 1911 | 52157 |
Andrew D. Ellington | 96 | 569 | 43262 |
Nam-Gyu Park | 94 | 420 | 48648 |
Steven J. Cooke | 93 | 937 | 34644 |
Lenore Fahrig | 89 | 246 | 40968 |