Institution
UPRRP College of Natural Sciences
About: UPRRP College of Natural Sciences is a based out in . It is known for research contribution in the topics: Apoptosis & Population. The organization has 9323 authors who have published 11826 publications receiving 284172 citations.
Topics: Apoptosis, Population, Gene, Oxidative stress, Signal transduction
Papers published on a yearly basis
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TL;DR: A simple synthesis of Rh-Fe(3)O(4) heterodimer nanocrystals was achieved by controlled one-pot thermolysis and exhibited excellent activities for the selective reduction of nitroarenes and alkenes.
106 citations
TL;DR: This review highlights potential use of neferine, liensinine, isoliens inine, and nuciferine in clinical trials and mechanism of the potential chemical entities from N.nucifera via structure activity relationship needs to be explored to guarantee the stability and safety for the clinical use.
Abstract: Nelumbo nucifera, also known as sacred lotus, has primarily been used as food throughout the Asian continent, and its medicinal values have been described in Ayurvedic and Traditional Chinese Medicine. The purpose of this study is to systematically characterize the chemical profiling and pharmacological activities of N. nucifera. Herein, we critically reviewed and analysed the phytochemical and pharmacological reports of N. nucifera. Our search for the keyword 'Nelumbo nucifera pharmacology' in all databases reported in Web of Science yielded 373 results excluding reviews and abstracts in document types. Two hundred and forty-three spectrum natural compounds from different parts of N. nucifera belonging to diverse chemical groups, including alkaloids, flavonoids, glycosides, terpenoids, steroids, fatty acids, proteins, minerals, and vitamins have been reported. In addition, distinct pharmacological activities, mainly against cancer, microbial infection, diabetes, inflammation, atherosclerosis, and obesity, have been associated with crude extracts, fractions, and isolated compounds. This review highlights potential use of neferine, liensinine, isoliensinine, and nuciferine in clinical trials. In depth, mechanism of the potential chemical entities from N. nucifera via structure activity relationship needs to be explored to guarantee the stability and safety for the clinical use. Copyright © 2016 John Wiley & Sons, Ltd.
106 citations
University of Pennsylvania1, University of Maryland, Baltimore2, Neuroscience Research Australia3, University of New South Wales4, State University of New York Upstate Medical University5, University of Marburg6, University of Newcastle7, University of Melbourne8, University of Queensland9, University of New Mexico10, National University of Singapore11, Nanyang Technological University12, Baylor College of Medicine13, International University Of Catalonia14, Casa Sollievo della Sofferenza15, University of Bari16, Goethe University Frankfurt17, University of Basel18, Stellenbosch University19, New Generation University College20, Seoul National University Hospital21, UPRRP College of Natural Sciences22, University of Münster23, Hospital General Universitario Gregorio Marañón24, Georgia State University25, Georgia Institute of Technology26, Dresden University of Technology27, Johns Hopkins University28, University of Toyama29, Montreal Neurological Institute and Hospital30, University of Zurich31, National Institutes of Health32, Charles University in Prague33, Academy of Sciences of the Czech Republic34, Czech Technical University in Prague35, Maastricht University36, University of Oxford37, University of California, Irvine38, University of Cape Town39, University of Antioquia40, University of Barcelona41, University of Southern California42, Harvard University43, Boston Children's Hospital44, Hartford Hospital45, Yale University46, Monash University47, Geneva College48
TL;DR: Whether the batch adjustment method, ComBat, can further reduce site-related heterogeneity and thus increase statistical power and recommend applying the ComBat function to attenuate potential effects of site in ENIGMA projects and other multi-site structural imaging work.
106 citations
TL;DR: In human A549 non–small lung cancer cells, kaempferol strongly blocked the enhancement of cell migration by TGF-β1–induced EMT through recovering the loss of E-cadherin and suppressing the induction of mesenchymal markers as well as the upregulation of TGF–mediated matrix metalloproteinase-2 activity.
106 citations
TL;DR: Comparisons with the structures of the enzyme I–HPr and IIAGlc–glycerol kinase complexes reveal how similar binding surfaces can be formed with underlying backbone scaffolds that are structurally dissimilar and highlight the role of redundancy and side chain conformational plasticity.
Abstract: The solution structure of the second protein-protein complex of the Escherichia coli phosphoenolpyruvate: sugar phosphotransferase system, that between histidine-containing phosphocarrier protein (HPr) and glucose-specific enzyme IIA(Glucose) (IIA(Glc)), has been determined by NMR spectroscopy, including the use of dipolar couplings to provide long-range orientational information and newly developed rigid body minimization and constrained/restrained simulated annealing methods. A protruding convex surface on HPr interacts with a complementary concave depression on IIA(Glc). Both binding surfaces comprise a central hydrophobic core region surrounded by a ring of polar and charged residues, positive for HPr and negative for IIA(Glc). Formation of the unphosphorylated complex, as well as the phosphorylated transition state, involves little or no change in the protein backbones, but there are conformational rearrangements of the interfacial side chains. Both HPr and IIA(Glc) recognize a variety of structurally diverse proteins. Comparisons with the structures of the enzyme I-HPr and IIA(Glc)-glycerol kinase complexes reveal how similar binding surfaces can be formed with underlying backbone scaffolds that are structurally dissimilar and highlight the role of redundancy and side chain conformational plasticity.
105 citations
Authors
Showing all 9323 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Hyun-Chul Kim | 176 | 4076 | 183227 |
| Alfred L. Goldberg | 156 | 474 | 88296 |
| Stephen J. O'Brien | 153 | 1062 | 93025 |
| Taeghwan Hyeon | 139 | 563 | 75814 |
| Keiji Tanaka | 129 | 594 | 82885 |
| Csaba Szabó | 123 | 958 | 61791 |
| Young Hee Lee | 122 | 1168 | 61107 |
| Angus C. Nairn | 118 | 469 | 44330 |
| John P. Giesy | 114 | 1162 | 62790 |
| Graham L. Collingridge | 103 | 353 | 51160 |
| Ki-Hyun Kim | 99 | 1911 | 52157 |
| Andrew D. Ellington | 96 | 569 | 43262 |
| Nam-Gyu Park | 94 | 420 | 48648 |
| Steven J. Cooke | 93 | 937 | 34644 |
| Lenore Fahrig | 89 | 246 | 40968 |