Institution
UPRRP College of Natural Sciences
About: UPRRP College of Natural Sciences is a based out in . It is known for research contribution in the topics: Apoptosis & Population. The organization has 9323 authors who have published 11826 publications receiving 284172 citations.
Topics: Apoptosis, Population, Gene, Oxidative stress, Signal transduction
Papers published on a yearly basis
Papers
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TL;DR: The crystal structures of the complexes with either NMN or FK-866 show that the enzymatic active site of visfatin is optimized for Nicotinamide binding and that the nicotinamide-binding site is important for inhibition by FK -866, raising the intriguing possibility that the glucose metabolism and the NAD biosynthesis are linked by visFatin.
115 citations
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TL;DR: Cha et al. as discussed by the authors show that SIRT2 suppression by miR-200c enhances acetylation levels and enzymatic activities of glycolytic enzymes and contributes to metabolic reprogramming of human induced pluripotent stem cells.
Abstract: Cha et al. show that SIRT2 suppression by miR-200c enhances acetylation levels and enzymatic activities of glycolytic enzymes and contributes to metabolic reprogramming of human induced pluripotent stem cells and human embryonic stem cells.
115 citations
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TL;DR: The neuroprotective effect of hesperetin was found to be a multipotent effect, involving the inhibition of oxidative stress, neuroinflammation, apoptotic cell death, and cognitive consolidation against Aβ-induced neurodegeneration and memory impairment.
Abstract: Hesperetin is a bioactive flavonoid in the body, produced from hesperidin. No comprehensive studies have shown its protective effects in neurodegenerative disorders. Here, we hypothesized that hesperetin may protect the mice brain against Aβ-induced neurodegeneration. Twenty-four hours after intracerebroventricular injection of Aβ1-42, the treated group was injected hesperetin. For in vitro experiments, HT22 and BV-2 cells were used. Immunoblot, immunofluorescence, and behavioral analyses were used to evaluate the different parameters. Our results indicated that hesperetin significantly attenuated oxidative stress, as assessed by the expression of Nrf2/HO-1 and LPO and ROS assays, in the hippocampus, cortex, and in vitro HT22 cells. Similarly, activated glial cells were regulated by hesperetin, as assessed by the expression of GFAP and Iba-1. Moreover, the expression of TLR4, p-NF-κB, and downstream targets was analyzed; the results showed that hesperetin reinstated the expression of these markers. The effects of hesperetin were further confirmed by using specific TLR4 and p-NF-κB inhibitors in BV-2 cells. Next, we evaluated Aβ pathology in the cortex, hippocampus, and HT22 cells, showing that hesperetin significantly reduced the Aβ pathology. Furthermore, the antiapoptotic effects of hesperetin were assessed, which showed strong antiapoptotic effects. Overall, the neuroprotective effect of hesperetin was found to be a multipotent effect, involving the inhibition of oxidative stress, neuroinflammation, apoptotic cell death, and cognitive consolidation. Given antioxidant, anti-inflammatory, and antiapoptotic potentials against Aβ-induced neurodegeneration and memory impairment, hesperetin may be a promising therapeutic agent for Alzheimer's disease-like neurological disorders.
115 citations
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TL;DR: A mechanism whereby cordycepin induces apoptosis of human leukemia cells through a signaling cascade involving a ROS-mediated caspase pathway is supported.
115 citations
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TL;DR: It is suggested that orchiectomy accelerates the post-ischemic activation of MnSOD and reduces reactive oxygen species and lipid peroxidation, resulting in reduced kidney susceptibility to I/R injury.
114 citations
Authors
Showing all 9323 results
Name | H-index | Papers | Citations |
---|---|---|---|
Hyun-Chul Kim | 176 | 4076 | 183227 |
Alfred L. Goldberg | 156 | 474 | 88296 |
Stephen J. O'Brien | 153 | 1062 | 93025 |
Taeghwan Hyeon | 139 | 563 | 75814 |
Keiji Tanaka | 129 | 594 | 82885 |
Csaba Szabó | 123 | 958 | 61791 |
Young Hee Lee | 122 | 1168 | 61107 |
Angus C. Nairn | 118 | 469 | 44330 |
John P. Giesy | 114 | 1162 | 62790 |
Graham L. Collingridge | 103 | 353 | 51160 |
Ki-Hyun Kim | 99 | 1911 | 52157 |
Andrew D. Ellington | 96 | 569 | 43262 |
Nam-Gyu Park | 94 | 420 | 48648 |
Steven J. Cooke | 93 | 937 | 34644 |
Lenore Fahrig | 89 | 246 | 40968 |