Institution
UPRRP College of Natural Sciences
About: UPRRP College of Natural Sciences is a based out in . It is known for research contribution in the topics: Apoptosis & Population. The organization has 9323 authors who have published 11826 publications receiving 284172 citations.
Topics: Apoptosis, Population, Gene, Oxidative stress, Signal transduction
Papers published on a yearly basis
Papers
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TL;DR: In this article, a new method of ettringite crystal growth by combining calcium hydroxide and aluminum sulfate solutions was devised to reliably produce crystals that could be seen with a light microscope.
150 citations
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TL;DR: Growth conditions are imposed on f which yield the existence of at least three symmetric positive solutions to the second-order boundary value problem.
150 citations
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TL;DR: In this article, the authors examine existing catch-and-release research from a welfare perspective to determine the extent to which potential pain and suffering could be caused and identify strategies that anglers may adopt that minimize these effects through changes in either gear (e.g., type of hook, bait, or net) or angling practices.
150 citations
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TL;DR: It is shown that such heterostructures can be assembled from chemically exfoliated 2D crystals, allowing for low-cost and scalable methods to be used in device fabrication.
Abstract: The new paradigm of heterostructures based on two-dimensional (2D) atomic crystals has already led to the observation of exciting physical phenomena and creation of novel devices. The possibility of combining layers of different 2D materials in one stack allows unprecedented control over the electronic and optical properties of the resulting material. Still, the current method of mechanical transfer of individual 2D crystals, though allowing exceptional control over the quality of such structures and interfaces, is not scalable. Here we show that such heterostructures can be assembled from chemically exfoliated 2D crystals, allowing for low-cost and scalable methods to be used in the device fabrication.
150 citations
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TL;DR: Results show that the HDAC inhibitor TSA sensitized ER α-negative, antihormone-unresponsive breast cancer cells to tamoxifen treatment possibly by upregulating ER β activity.
Abstract: Many cases of breast cancer show loss of estrogen receptor (ER) α expression, which leads to unresponsiveness to antihormonal treatment even though there is no loss of the structurally and biochemically similar ER β. ER activity is positively and negatively regulated by transcriptional regulators such as histone deacetylase (HDAC), which is known to be a negative ER regulator. Here, we evaluated using ER β as an alternative target for tamoxifen therapy by treating ER α-negative, β-positive breast cancer cells with the HDAC inhibitor trichostatin A (TSA), and testing whether tamoxifen responsiveness increased following upregulation of ER β. TSA enhanced the overall ER transcriptional activity in these cells, as visualized by estrogen response element-regulated reporter and the expression of progesterone receptor, a known ER target, without ER α restoration. Additionally, TSA induced the expression and nuclear translocation of ER β but not α, suggesting that these actions leading to increase of ER transcriptional activity are mediated through ER β rather than α. Furthermore, following treatment with TSA, the formerly unresponsive MDA-MB-231 and Hs578T breast cancer cells became responsive to tamoxifen. However, reduction of ER β expression by short interfering RNA abrogated this TSA-induced sensitization effect in these cells. Together, these results show that the HDAC inhibitor TSA sensitized ER α-negative, antihormone-unresponsive breast cancer cells to tamoxifen treatment possibly by upregulating ER β activity.
150 citations
Authors
Showing all 9323 results
Name | H-index | Papers | Citations |
---|---|---|---|
Hyun-Chul Kim | 176 | 4076 | 183227 |
Alfred L. Goldberg | 156 | 474 | 88296 |
Stephen J. O'Brien | 153 | 1062 | 93025 |
Taeghwan Hyeon | 139 | 563 | 75814 |
Keiji Tanaka | 129 | 594 | 82885 |
Csaba Szabó | 123 | 958 | 61791 |
Young Hee Lee | 122 | 1168 | 61107 |
Angus C. Nairn | 118 | 469 | 44330 |
John P. Giesy | 114 | 1162 | 62790 |
Graham L. Collingridge | 103 | 353 | 51160 |
Ki-Hyun Kim | 99 | 1911 | 52157 |
Andrew D. Ellington | 96 | 569 | 43262 |
Nam-Gyu Park | 94 | 420 | 48648 |
Steven J. Cooke | 93 | 937 | 34644 |
Lenore Fahrig | 89 | 246 | 40968 |