Voronezh State University

About: Voronezh State University is a education organization based out in Voronezh, Russia. It is known for research contribution in the topics: Silicon & Boundary value problem. The organization has 5166 authors who have published 6097 publications receiving 31680 citations. The organization is also known as: VSU & Voronezh University.

Application of Molecular Modeling to Development of New Factor Xa Inhibitors.

Abstract: In consequence of the key role of factor Xa in the clotting cascade and absence of its activity in the processes that do not affect coagulation, this protein is an attractive target for development of new blood coagulation inhibitors. Factor Xa is more effective and convenient target for creation of anticoagulants than thrombin, inhibition of which may cause some side effects. This study is aimed at finding new inhibitors of factor Xa by molecular computer modeling including docking SOL and postdocking optimization DISCORE programs. After validation of molecular modeling methods on well-known factor Xa inhibitors the virtual screening of NCI Diversity and Voronezh State University databases of ready-made low molecular weight species has been carried out. Seventeen compounds selected on the basis of modeling results have been tested experimentally in vitro. It has been found that 12 of them showed activity against factor Xa (IC50 = 1.8–40 μM). Based on analysis of the results, the new original compound was synthesized and experimentally verified. It shows activity against factor Xa with IC50 value of 0.7 μM.

Global Innovational Networks : Sense and Role in Development of Global Economy

Abstract: The starting point for this research is the authors’ hypothesis that global innovational networks play an important role in the development of the modern global economy because they stimulate international cooperation in the innovational sphere, the translation of knowledge in the global economic system, and general scientific and technological development and production development. The purpose of this article is to verify this hypothesis, conduct a complex study on the phenomenon of global innovational networks, and determine their purpose and role in the development of the modern global economy. The methodological basis of this research is founded on the logical modeling of economic systems and methods of structural and functional, systemic, and problem analysis. In the process of the research, the authors studied examples of global innovational networks created based on modern Europe that include countries from all over the world, namely, Horizon 2020, ERA.Net RUS, and Eurocores (European Collaboration Research). The authors also conducted complex analysis of statistical information on various global innovational networks, the dynamics of the quantity of innovational projects, realized participation in global innovational networks, and the significance of the global innovational indexes of countries of Western Europe (Great Britain, Germany, France, and Italy), Central and Eastern Europe (Czech Republic, Poland, Hungary, and Latvia) and Russia in 2005-2014. The authors provide a sense of global innovational networks, including their peculiarities and advantages; build a structural and logical model of the global market of innovations; and determine the role of global innovational networks in the development of the modern global economy.

Asymptotic Stability of Periodic Solutions for Nonsmooth Differential Equations with Application to the Nonsmooth van der Pol Oscillator

Abstract: In this paper we study the existence, uniqueness, and asymptotic stability of the periodic solutions of the Lipschitz system $\dot{x}=\varepsilon g(t,x,\varepsilon)$, where $\varepsilon>0$ is small. Our results extend the classical second Bogoliubov theorem for the existence of stable periodic solutions to nonsmooth differential systems. As an application we prove the existence of asymptotically stable $2\pi$-periodic solutions of the nonsmooth van der Pol oscillator $\ddot{u}+\varepsilon\,(|u|-1)\,\dot{u}+(1+a\varepsilon)u=\varepsilon\lambda\sin t$. Moreover, we construct the so-called resonance curves that describe the dependence of the amplitude of these solutions as a function of the parameters a and $\lambda$. Finally we compare such curves with the resonance curves of the classical van der Pol oscillator $\ddot{u}+\varepsilon\,\bigl(u^2-1\bigr)\,\dot{u}+(1+a\varepsilon)u=\varepsilon\lambda\sin t$.

Structure of Zn 3 P 2

Abstract: The structure of Zn3P2 (P 42/nmc, a = b = 8. 0785 A, c = 11. 3966 A) was solved and refined to R = 3. 2% in a precision X-ray diffraction experiment (λ-MoK a, graphite monochromator on a primary beam, 27,496 reflections) . Interatomic distances and bond angles have been determined. The fcc lattice of the structure is built from phosphorus atoms, and the zinc atoms occupy 3/4 of all tetrahedral voids; the structure is described by two equivalent models where 1/4 occupied (by zinc atoms) and 1/4 vacant voids change places. The zinc atoms that occupy the voids following the diamond principle do not change places.

Properties of cds films prepared from thiourea complexes of cadmium salts

Abstract: Cadmium sulfide films were prepared by spray pyrolysis of thiourea complexes, and their optical, electrical, luminescent, and structural properties were investigated. The results are used to elucidate the mechanism underlying the effect of the nature of the thiourea complex on the properties of the films. The crystal structure and perfection of the films are shown to correlate with the structure of the first coordination sphere of the thiourea complex.