Vrije Universiteit Brussel

About: Vrije Universiteit Brussel is a education organization based out in Brussels, Belgium. It is known for research contribution in the topics: Population & Context (language use). The organization has 14295 authors who have published 38258 publications receiving 1203970 citations. The organization is also known as: VUB.

Nanobodies as novel agents for cancer therapy

Abstract: Nanobodies are the smallest fragments of naturally occurring heavy-chain antibodies that have evolved to be fully functional in the absence of a light chain. As such, the cloning and selection of antigen-specific nanobodies obviate the need for construction and screening of large libraries, and for lengthy and unpredictable in vitro affinity maturation steps. The unique and well-characterised properties enable nanobodies to excel conventional therapeutic antibodies in terms of recognising uncommon or hidden epitopes, binding into cavities or active sites of protein targets, tailoring of half-life, drug format flexibility, low immunogenic potential and ease of manufacture. Moreover, the favourable biophysical and pharmacological properties of nanobodies, together with the ease of formatting them into multifunctional protein therapeutics, leaves them ideally placed as a new generation of antibody-based therapeutics. This review describes the state of the art on nanobodies and illustrates their potential as cancer therapeutic agents.

A survey on reactive programming

Abstract: Reactive programming has recently gained popularity as a paradigm that is well-suited for developing event-driven and interactive applications. It facilitates the development of such applications by providing abstractions to express time-varying values and automatically managing dependencies between such values. A number of approaches have been recently proposed embedded in various languages such as Haskell, Scheme, JavaScript, Java, .NET, etc. This survey describes and provides a taxonomy of existing reactive programming approaches along six axes: representation of time-varying values, evaluation model, lifting operations, multidirectionality, glitch avoidance, and support for distribution. From this taxonomy, we observe that there are still open challenges in the field of reactive programming. For instance, multidirectionality is supported only by a small number of languages, which do not automatically track dependencies between time-varying values. Similarly, glitch avoidance, which is subtle in reactive programs, cannot be ensured in distributed reactive programs using the current techniques.

Higgs Boson studies at future particle colliders

Abstract: This document aims to provide an assessment of the potential of future colliding beam facilities to perform Higgs boson studies. The analysis builds on the submissions made by the proponents of future colliders to the European Strategy Update process, and takes as its point of departure the results expected at the completion of the HL-LHC program. This report presents quantitative results on many aspects of Higgs physics for future collider projects of sufficient maturity using uniform methodologies.