Institution
Vrije Universiteit Brussel
Education•Brussels, Belgium•
About: Vrije Universiteit Brussel is a education organization based out in Brussels, Belgium. It is known for research contribution in the topics: Population & Context (language use). The organization has 14295 authors who have published 38258 publications receiving 1203970 citations. The organization is also known as: VUB.
Topics: Population, Context (language use), Large Hadron Collider, Palliative care, Computer science
Papers published on a yearly basis
Papers
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TL;DR: An algorithm for the cryopreservation of sperm and testicular tissue is proposed for prepubertal boys and adolescent males at high risk of fertility loss and after consideration of the relevant ethical and legal challenges.
Abstract: STUDY QUESTION What clinical practices, patient management strategies and experimental methods are currently being used to preserve and restore the fertility of prepubertal boys and adolescent males? SUMMARY ANSWER Based on a review of the clinical literature and research evidence for sperm freezing and testicular tissue cryopreservation, and after consideration of the relevant ethical and legal challenges, an algorithm for the cryopreservation of sperm and testicular tissue is proposed for prepubertal boys and adolescent males at high risk of fertility loss. WHAT IS KNOWN ALREADY A known late effect of the chemotherapy agents and radiation exposure regimes used to treat childhood cancers and other non-malignant conditions in males is the damage and/or loss of the proliferating spermatogonial stem cells in the testis. Cryopreservation of spermatozoa is the first line treatment for fertility preservation in adolescent males. Where sperm retrieval is impossible, such as in prepubertal boys, or it is unfeasible in adolescents prior to the onset of ablative therapies, alternative experimental treatments such as testicular tissue cryopreservation and the harvesting and banking of isolated spermatogonial stem cells can now be proposed as viable means of preserving fertility. STUDY DESIGN, SIZE, DURATION Advances in clinical treatments, patient management strategies and the research methods used to preserve sperm and testicular tissue for prepubertal boys and adolescents were reviewed. A snapshot of the up-take of testis cryopreservation as a means to preserve the fertility of young males prior to December 2012 was provided using a questionnaire. PARTICIPANTS/MATERIALS, SETTING, METHODS A comprehensive literature review was conducted. In addition, survey results of testis freezing practices in young patients were collated from 24 European centres and Israeli University Hospitals. MAIN RESULTS AND THE ROLE OF CHANCE There is increasing evidence of the use of testicular tissue cryopreservation as a means to preserve the fertility of pre- and peri-pubertal boys of up to 16 year-old. The survey results indicate that of the 14 respondents, half of the centres were actively offering testis tissue cryobanking as a means of safeguarding the future fertility of boys and adolescents as more than 260 young patients (age range less than 1 year old to 16 years of age), had already undergone testicular tissue retrieval and storage for fertility preservation. The remaining centres were considering the implementation of a tissue-based fertility preservation programme for boys undergoing oncological treatments. LIMITATIONS, REASONS FOR CAUTION The data collected were limited by the scope of the questionnaire, the geographical range of the survey area, and the small number of respondents. WIDER IMPLICATIONS OF THE FINDINGS The clinical and research questions identified and the ethical and legal issues raised are highly relevant to the multi-disciplinary teams developing treatment strategies to preserve the fertility of prepubertal and adolescent boys who have a high risk of fertility loss due to ablative interventions, trauma or genetic pre-disposition. STUDY FUNDING/COMPETING INTEREST(S) The work was funded by the European Society of Human Reproduction and Embryology (ESHRE).
264 citations
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TL;DR: In this paper, two sets of methods have been suggested and tested based on Belgian data, which involve computation of quantile perturbations on extreme precipitation intensities, and the tested assumption that the same perturbation holds for daily and sub-daily time scales.
264 citations
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TL;DR: In this review, the set-up and data interpretation of experimental designs (screening, response surface, and mixture designs) are discussed and an adaptation of the algorithm of Dong and the estimation of factor effects from supersaturated design results are discussed.
264 citations
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TL;DR: Specificity of polysaccharide use by the colon microbiota may determine diet-induced alterations in the microbiota and consequent metabolic effects, and both bifidogenic and butyrogenic health-promoting effects.
264 citations
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TL;DR: The list of winners and runners-up in the 2016 Rio Olympics and Paralympic Games is revealed, with a record-breaking turnout of more than 3.3 million people.
Abstract: M. G. Aartsen, K. Abraham, M. Ackermann, J. Adams, J. A. Aguilar, M. Ahlers, M. Ahrens, D. Altmann, K. Andeen, T. Anderson, I. Ansseau, G. Anton, M. Archinger, C. Arguelles, T. C. Arlen, J. Auffenberg, S. Axani, X. Bai, S. W. Barwick, V. Baum, R. Bay, J. J. Beatty, J. Becker Tjus, K.-H. Becker, S. BenZvi, P. Berghaus, D. Berley, E. Bernardini, A. Bernhard, D. Z. Besson, G. Binder, D. Bindig, M. Bissok, E. Blaufuss, S. Blot, D. J. Boersma, C. Bohm, M. Borner, F. Bos, D. Bose, S. Boser, O. Botner, J. Braun, L. Brayeur, H.-P. Bretz, A. Burgman, J. Casey, M. Casier, E. Cheung, D. Chirkin, A. Christov, K. Clark, L. Classen, S. Coenders, G. H. Collin, J. M. Conrad, D. F. Cowen, A. H. Cruz Silva, J. Daughhetee, J. C. Davis, M. Day, J. P. A. M. de Andre, C. De Clercq, E. del Pino Rosendo, H. Dembinski, S. De Ridder, P. Desiati, K. D. de Vries, G. de Wasseige, M. de With, T. DeYoung, J. C. Diaz-Velez, V. di Lorenzo, H. Dujmovic, J. P. Dumm, M. Dunkman, B. Eberhardt, T. Ehrhardt, B. Eichmann, S. Euler, P. A. Evenson, S. Fahey, A. R. Fazely, J. Feintzeig, J. Felde, K. Filimonov, C. Finley, S. Flis, C.-C. Fosig, A. Franckowiak, T. Fuchs, T. K. Gaisser, R. Gaior, J. Gallagher, L. Gerhardt, K. Ghorbani, W. Giang, L. Gladstone, M. Glagla, T. Glusenkamp, A. Goldschmidt, G. Golup, J. G. Gonzalez, D. GOra, D. Grant, Z. Griffith, C. Haack, A. Haj Ismail, A. Hallgren, F. Halzen, E. Hansen, B. Hansmann, T. Hansmann, K. Hanson, D. Hebecker, D. Heereman, K. Helbing, R. Hellauer, S. Hickford, J. Hignight, G. C. Hill, K. D. Hoffman, R. Hoffmann, K. Holzapfel, A. Homeier, K. Hoshina, F. Huang, M. Huber, W. Huelsnitz, K. Hultqvist, S. In, A. Ishihara, E. Jacobi, G. S. Japaridze, M. Jeong, K. Jero, B. J. P. Jones, M. Jurkovic, A. Kappes, T. Karg, A. Karle, U. Katz, M. Kauer, A. Keivani, J. L. Kelley, J. Kemp, A. Kheirandish, M. Kim, T. Kintscher, J. Kiryluk, T. Kittler, S. R. Klein, G. Kohnen, R. Koirala, H. Kolanoski, R. Konietz, L. Kopke, C. Kopper, S. Kopper, D. J. Koskinen, M. Kowalski, K. Krings, M. Kroll, G. Kruckl, C. Kruger, J. Kunnen, S. Kunwar, N. Kurahashi, T. Kuwabara, M. Labare, J. L. Lanfranchi, M. J. Larson, D. Lennarz, M. Lesiak-Bzdak, M. Leuermann, J. Leuner, L. Lu, J. Lunemann, J. Madsen, G. Maggi, K. B. M. Mahn, S. Mancina, M. Mandelartz, R. Maruyama, K. Mase, R. Maunu, F. McNally, K. Meagher, M. Medici, M. Meier, A. Meli, T. Menne, G. Merino, T. Meures, S. Miarecki, E. Middell, L. Mohrmann, T. Montaruli, M. Moulai, R. Nahnhauer, U. Naumann, G. Neer, H. Niederhausen, S. C. Nowicki, D. R. Nygren, A. Obertacke Pollmann, A. Olivas, A. Omairat, A. O, Murchadha, T. Palczewski, H. Pandya, D. V. Pankova, O. Penek, J. A. Pepper, C. Perez de los Heros, C. Pfendner, D. Pieloth, E. Pinat, J. Posselt, P. B. Price, G. T. Przybylski, M. Quinnan, C. Raab, L. Radel, M. Rameez, K. Rawlins, R. Reimann, M. Relich, E. Resconi, W. Rhode, M. Richman, B. Riedel, S. Robertson, M. Rongen, C. Rott, T. Ruhe, D. Ryckbosch, D. Rysewyk, L. Sabbatini, S. E. Sanchez Herrera, A. Sandrock, J. Sandroos, S. Sarkar, K. Satalecka, M. Schimp, P. Schlunder, T. Schmidt, S. Schoenen, S. Schoneberg, A. Schonwald, L. Schumacher, D. Seckel, S. Seunarine, D. Soldin, M. Song, G. M. Spiczak, C. Spiering, M. Stahlberg, M. Stamatikos, T. Stanev, A. Stasik, A. Steuer, T. Stezelberger, R. G. Stokstad, A. Stosl, R. Strom, N. L. Strotjohann, G. W. Sullivan, M. Sutherland, H. Taavola, I. Taboada, J. Tatar, S. Ter-Antonyan, A. Terliuk, G. TesiC, S. Tilav, P. A. Toale, M. N. Tobin, S. Toscano, D. Tosi, M. Tselengidou, A. Turcati, E. Unger, M. Usner, S. Vallecorsa, J. Vandenbroucke, N. van Eijndhoven, S. Vanheule, M. van Rossem, J. van Santen, J. Veenkamp, M. Vehring, M. Voge, M. Vraeghe, C. Walck, A. Wallace, M. Wallraff, N. Wandkowsky, Ch. Weaver, C. Wendt, S. Westerhoff, B. J. Whelan, S. Wickmann, K. Wiebe, C. H. Wiebusch, L. Wille, D. R. Williams, L. Wills, H. Wissing, M. Wolf, T. R. Wood, E. Woolsey, K. Woschnagg, D. L. Xu, X. W. Xu, Y. Xu, J. P. Yanez, G. Yodh, S. Yoshida and M. Zoll (IceCube Collaboration)
264 citations
Authors
Showing all 14460 results
Name | H-index | Papers | Citations |
---|---|---|---|
D. M. Strom | 176 | 3167 | 194314 |
Christopher M. Dobson | 150 | 1008 | 105475 |
Dario Bisello | 140 | 2005 | 107859 |
Giorgio Maggi | 135 | 1323 | 90270 |
Jörg P. Rachen | 133 | 400 | 94766 |
Pascal Vanlaer | 133 | 1270 | 91850 |
Freya Blekman | 133 | 1388 | 89808 |
Jorgen D'Hondt | 132 | 1257 | 89685 |
Tae Jeong Kim | 132 | 1420 | 93959 |
Xavier Janssen | 132 | 1309 | 86860 |
Matthias Ulrich Mozer | 131 | 1185 | 87709 |
Valery Zhukov | 129 | 1255 | 83330 |
Stephanie Beauceron | 129 | 1213 | 86374 |
Steven Lowette | 128 | 1094 | 78876 |
Yen-Jie Lee | 128 | 1247 | 82542 |