Vrije Universiteit Brussel

About: Vrije Universiteit Brussel is a education organization based out in Brussels, Belgium. It is known for research contribution in the topics: Population & Context (language use). The organization has 14295 authors who have published 38258 publications receiving 1203970 citations. The organization is also known as: VUB.

Searches for invisible decays of the Higgs boson in pp collisions at √s = 7, 8, and 13 TeV

Abstract: Searches for invisible decays of the Higgs boson are presented. The data collected with the CMS detector at the LHC correspond to integrated luminosities of 5.1, 19.7, and 2.3 fb−1 at centre-of-mass energies of 7, 8, and 13 TeV, respectively. The search channels target Higgs boson production via gluon fusion, vector boson fusion, and in association with a vector boson. Upper limits are placed on the branching fraction of the Higgs boson decay to invisible particles, as a function of the assumed production cross sections. The combination of all channels, assuming standard model production, yields an observed (expected) upper limit on the invisible branching fraction of 0.24 (0.23) at the 95% confidence level. The results are also interpreted in the context of Higgs-portal dark matter models.

Review of FACTS technologies and applications for power quality in smart grids with renewable energy systems

Abstract: In the last two decades, emerging use of renewable and distributed energy sources in electricity grid has created new challenges for the utility regarding the power quality, voltage stabilization and efficient energy utilization. Power electronic converters are extensively utilized to interface the emerging energy systems (without and with energy storage) and smart buildings with the transmission and distribution systems. Flexible ac transmission systems (FACTSs) and voltage-source converters, with smart dynamic controllers, are emerging as a stabilization and power filtering equipment to improve the power quality. Also, distributed FACTSs play an important role in improving the power factor, energy utilization, enhancing the power quality, and ensuring efficient energy utilization and energy management in smart grids with renewable energy sources. This paper presents a literature survey of FACTS technology tools and applications for power quality and efficient renewable energy system utilization.

Validation of the Zebrafish Pentylenetetrazol Seizure Model: Locomotor versus Electrographic Responses to Antiepileptic Drugs

Abstract: Zebrafish have recently emerged as an attractive in vivo model for epilepsy. Seven-day-old zebrafish larvae exposed to the GABAA antagonist pentylenetetrazol (PTZ) exhibit increased locomotor activity, seizure-like behavior, and epileptiform electrographic activity. A previous study showed that 12 out of 13 antiepileptic drugs (AEDs) suppressed PTZ-mediated increases in larval movement, indicating the potential utility of zebrafish as a high-throughput in vivo model for AED discovery. However, a question remained as to whether an AED-induced decrease in locomotion is truly indicative of anticonvulsant activity, as some drugs may impair larval movement through other mechanisms such as general toxicity or sedation. We therefore carried out a study in PTZ-treated zebrafish larvae, to directly compare the ability of AEDs to inhibit seizure-like behavioral manifestations with their capacity to suppress epileptiform electrographic activity. We re-tested the 13 AEDs of which 12 were previously reported to inhibit convulsions in the larval movement tracking assay, administering concentrations that did not, on their own, impair locomotion. In parallel, we carried out open-field recordings on larval brains after treatment with each AED. For the majority of AEDs we obtained the same response in both the behavioral and electrographic assays. Overall our data correlate well with those reported in the literature for acute rodent PTZ tests, indicating that the larval zebrafish brain is more discriminatory than previously thought in its response to AEDs with different modes of action. Our results underscore the validity of using the zebrafish larval locomotor assay as a rapid first-pass screening tool in assessing the anticonvulsant and/or proconvulsant activity of compounds, but also highlight the importance of performing adequate validation when using in vivo models.

Language networks: Their structure, function, and evolution

Abstract: Human language is the key evolutionary innovation that makes humans different from other species. And yet, the fabric of language is tangled and all levels of description (from semantics to syntax) involve multiple layers of complexity. Recent work indicates that the global traits displayed by such levels can be analyzed in terms of networks of connected words. Here, we review the state of the art on language webs and their potential relevance to cognitive science. The emergence of syntax through language acquisition is used as a case study to illustrate how the approach can shed light into relevant questions concerning language organization and its evolution. © 2010 Wiley Periodicals, Inc. Complexity, 2010

Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist

Abstract: Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) affect 150 million people annually. Despite effective antibiotic therapy, 30-50% of patients experience recurrent UTIs. In addition, the growing prevalence of UPEC that are resistant to last-line antibiotic treatments, and more recently to carbapenems and colistin, make UTI a prime example of the antibiotic-resistance crisis and emphasize the need for new approaches to treat and prevent bacterial infections. UPEC strains establish reservoirs in the gut from which they are shed in the faeces, and can colonize the periurethral area or vagina and subsequently ascend through the urethra to the urinary tract, where they cause UTIs. UPEC isolates encode up to 16 distinct chaperone-usher pathway pili, and each pilus type may enable colonization of a habitat in the host or environment. For example, the type 1 pilus adhesin FimH binds mannose on the bladder surface, and mediates colonization of the bladder. However, little is known about the mechanisms underlying UPEC persistence in the gut. Here, using a mouse model, we show that F17-like and type 1 pili promote intestinal colonization and show distinct binding to epithelial cells distributed along colonic crypts. Phylogenomic and structural analyses reveal that F17-like pili are closely related to pilus types carried by intestinal pathogens, but are restricted to extra-intestinal pathogenic E. coli. Moreover, we show that targeting FimH with M4284, a high-affinity inhibitory mannoside, reduces intestinal colonization of genetically diverse UPEC isolates, while simultaneously treating UTI, without notably disrupting the structural configuration of the gut microbiota. By selectively depleting intestinal UPEC reservoirs, mannosides could markedly reduce the rate of UTIs and recurrent UTIs.