Institution
Vrije Universiteit Brussel
Education•Brussels, Belgium•
About: Vrije Universiteit Brussel is a education organization based out in Brussels, Belgium. It is known for research contribution in the topics: Population & Context (language use). The organization has 14295 authors who have published 38258 publications receiving 1203970 citations. The organization is also known as: VUB.
Topics: Population, Context (language use), Large Hadron Collider, Palliative care, Computer science
Papers published on a yearly basis
Papers
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Centre national de la recherche scientifique1, Pierre-and-Marie-Curie University2, Kaiserslautern University of Technology3, Spanish National Research Council4, École Normale Supérieure5, Commissariat à l'énergie atomique et aux énergies alternatives6, Vrije Universiteit Brussel7, Katholieke Universiteit Leuven8, Sewanee: The University of the South9, Academy of Sciences of the Czech Republic10, University of Évry Val d'Essonne11, Canadian Institute for Advanced Research12, University of Bremen13, Stazione Zoologica Anton Dohrn14, IFREMER15, European Bioinformatics Institute16, Kyoto University17, Max Delbrück Center for Molecular Medicine18, University of Paris19, Aix-Marseille University20, National Science Foundation21, Bigelow Laboratory For Ocean Sciences22, University of Western Brittany23
TL;DR: Diversity emerged at all taxonomic levels, both within the groups comprising the ~11,200 cataloged morphospecies of eukaryotic plankton and among twice as many other deep-branching lineages of unappreciated importance in plankton ecology studies.
Abstract: Marine plankton support global biological and geochemical processes. Surveys of their biodiversity have hitherto been geographically restricted and have not accounted for the full range of plankton size. We assessed eukaryotic diversity from 334 size-fractionated photic-zone plankton communities collected across tropical and temperate oceans during the circumglobal Tara Oceans expedition. We analyzed 18S ribosomal DNA sequences across the intermediate plankton-size spectrum from the smallest unicellular eukaryotes (protists, >0.8 micrometers) to small animals of a few millimeters. Eukaryotic ribosomal diversity saturated at ~150,000 operational taxonomic units, about one-third of which could not be assigned to known eukaryotic groups. Diversity emerged at all taxonomic levels, both within the groups comprising the ~11,200 cataloged morphospecies of eukaryotic plankton and among twice as many other deep-branching lineages of unappreciated importance in plankton ecology studies. Most eukaryotic plankton biodiversity belonged to heterotrophic protistan groups, particularly those known to be parasites or symbiotic hosts.
1,378 citations
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University of Texas MD Anderson Cancer Center1, University of Sydney2, University of Southern California3, University of Modena and Reggio Emilia4, University of Turin5, Katholieke Universiteit Leuven6, University College Dublin7, University of Alberta8, Université libre de Bruxelles9, Vrije Universiteit Brussel10, Bristol-Myers Squibb11
TL;DR: Indirect comparisons suggest combination therapy provides improved efficacy relative to anti-programmed death-1 monotherapy and has a favorable benefit-risk profile.
Abstract: PurposeNivolumab provides clinical benefit (objective response rate [ORR], 31%; 95% CI, 20.8 to 42.9; disease control rate, 69%; 12-month overall survival [OS], 73%) in previously treated patients with DNA mismatch repair–deficient (dMMR)/microsatellite instability–high (MSI-H) metastatic colorectal cancer (mCRC); nivolumab plus ipilimumab may improve these outcomes. Efficacy and safety results for the nivolumab plus ipilimumab cohort of CheckMate-142, the largest single-study report of an immunotherapy combination in dMMR/MSI-H mCRC, are reported.Patients and MethodsPatients received nivolumab 3 mg/kg plus ipilimumab 1 mg/kg once every 3 weeks (four doses) followed by nivolumab 3 mg/kg once every 2 weeks. Primary end point was investigator-assessed ORR.ResultsOf 119 patients, 76% had received ≥ two prior systemic therapies. At median follow-up of 13.4 months, investigator-assessed ORR was 55% (95% CI, 45.2 to 63.8), and disease control rate for ≥ 12 weeks was 80%. Median duration of response was not reac...
1,339 citations
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Katholieke Universiteit Leuven1, Stanford University2, Max Planck Society3, Brown University4, St. Jude Children's Research Hospital5, University of Zurich6, Switch7, University of Pennsylvania8, Boston University9, Vrije Universiteit Brussel10, Hungarian Academy of Sciences11, University of Debrecen12
TL;DR: A combination of techniques from cell biology, biophysics, physical chemistry, structural biology, and bioinformatics are starting to help establish the molecular principles of an emerging field, thus paving the way for exciting discoveries, including novel therapeutic approaches for the treatment of age-related disorders.
1,317 citations
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Technical University of Denmark1, Åbo Akademi University2, VTT Technical Research Centre of Finland3, University of Copenhagen4, Katholieke Universiteit Leuven5, Vrije Universiteit Brussel6, Université Paris-Saclay7, Institute of Chartered Accountants of Nigeria8, Steno Diabetes Center9, University of Helsinki10, ETH Zurich11, Glostrup Hospital12, University of Southern Denmark13, King's College London14
TL;DR: It is shown how the human gut microbiome impacts the serum metabolome and associates with insulin resistance in 277 non-diabetic Danish individuals and suggested that microbial targets may have the potential to diminish insulin resistance and reduce the incidence of common metabolic and cardiovascular disorders.
Abstract: Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2 diabetes. Here we show how the human gut microbiome impacts the serum metabolome and associates with insulin resistance in 277 non-diabetic Danish individuals. The serum metabolome of insulin-resistant individuals is characterized by increased levels of branched-chain amino acids (BCAAs), which correlate with a gut microbiome that has an enriched biosynthetic potential for BCAAs and is deprived of genes encoding bacterial inward transporters for these amino acids. Prevotella copri and Bacteroides vulgatus are identified as the main species driving the association between biosynthesis of BCAAs and insulin resistance, and in mice we demonstrate that P. copri can induce insulin resistance, aggravate glucose intolerance and augment circulating levels of BCAAs. Our findings suggest that microbial targets may have the potential to diminish insulin resistance and reduce the incidence of common metabolic and cardiovascular disorders.
1,309 citations
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University Medical Center Groningen1, Novosibirsk State University2, Harvard University3, Aalto University4, Maastricht University5, Rega Institute for Medical Research6, Katholieke Universiteit Leuven7, Wageningen University and Research Centre8, Radboud University Nijmegen9, Broad Institute10, Vrije Universiteit Brussel11
TL;DR: Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based cohort shows relations between the microbiome and 126 exogenous and intrinsic host factors, including 31 intrinsic factors, 12 diseases, 19 drug groups, 4 smoking categories, and 60 dietary factors, and an important step toward a better understanding of environment-diet-microbe-host interactions.
Abstract: Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based cohort shows relations between the microbiome and 126 exogenous and intrinsic host factors, including 31 intrinsic factors, 12 diseases, 19 drug groups, 4 smoking categories, and 60 dietary factors. These factors collectively explain 18.7% of the variation seen in the interindividual distance of microbial composition. We could associate 110 factors to 125 species and observed that fecal chromogranin A (CgA), a protein secreted by enteroendocrine cells, was exclusively associated with 61 microbial species whose abundance collectively accounted for 53% of microbial composition. Low CgA concentrations were seen in individuals with a more diverse microbiome. These results are an important step toward a better understanding of environment-diet-microbe-host interactions.
1,272 citations
Authors
Showing all 14460 results
Name | H-index | Papers | Citations |
---|---|---|---|
D. M. Strom | 176 | 3167 | 194314 |
Christopher M. Dobson | 150 | 1008 | 105475 |
Dario Bisello | 140 | 2005 | 107859 |
Giorgio Maggi | 135 | 1323 | 90270 |
Jörg P. Rachen | 133 | 400 | 94766 |
Pascal Vanlaer | 133 | 1270 | 91850 |
Freya Blekman | 133 | 1388 | 89808 |
Jorgen D'Hondt | 132 | 1257 | 89685 |
Tae Jeong Kim | 132 | 1420 | 93959 |
Xavier Janssen | 132 | 1309 | 86860 |
Matthias Ulrich Mozer | 131 | 1185 | 87709 |
Valery Zhukov | 129 | 1255 | 83330 |
Stephanie Beauceron | 129 | 1213 | 86374 |
Steven Lowette | 128 | 1094 | 78876 |
Yen-Jie Lee | 128 | 1247 | 82542 |