Institution
Vrije Universiteit Brussel
Education•Brussels, Belgium•
About: Vrije Universiteit Brussel is a education organization based out in Brussels, Belgium. It is known for research contribution in the topics: Population & Context (language use). The organization has 14295 authors who have published 38258 publications receiving 1203970 citations. The organization is also known as: VUB.
Topics: Population, Context (language use), Large Hadron Collider, Palliative care, Computer science
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the authors examined the anaplerosis of glucose carbon in purified rat islets using specific 14C-labeled glucose tracers and concluded that 25% of the glucose carbon entering the Krebs cycle via anaphylaxis is channeled into protein synthesis.
408 citations
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TL;DR: A search for muon neutrinos from dark matter annihilation in the center of the Sun with the 79-string configuration of the IceCube neutrino telescope is performed, lowering the energy threshold and extending the search to the austral summer.
Abstract: We have performed a search for muon neutrinos from dark matter annihilation in the center of the Sun with the 79-string configuration of the IceCube neutrino telescope. For the first time, the DeepCore subarray is included in the analysis, lowering the energy threshold and extending the search to the austral summer. The 317 days of data collected between June 2010 and May 2011 are consistent with the expected background from atmospheric muons and neutrinos. Upper limits are set on the dark matter annihilation rate, with conversions to limits on spin-dependent and spin-independent scattering cross sections of weakly interacting massive particles (WIMPs) on protons, for WIMP masses in the range 20-5000 GeV=c(2). These are the most stringent spin-dependent WIMP-proton cross section limits to date above 35 GeV=c(2) for most WIMP models.
408 citations
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A. Abada1, Marcello Abbrescia2, Marcello Abbrescia3, Shehu S. AbdusSalam4 +1501 more•Institutions (239)
TL;DR: In this article, the physics opportunities of the Future Circular Collider (FC) were reviewed, covering its e+e-, pp, ep and heavy ion programs, and the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions.
Abstract: We review the physics opportunities of the Future Circular Collider, covering its e+e-, pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics.
407 citations
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TL;DR: Overall protein structural conservation within the CAP superfamily results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters target specificity and, therefore, the biological consequences.
Abstract: The cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) superfamily members are found in a remarkable range of organisms spanning each of the animal kingdoms. Within humans and mice, there are 31 and 33 individual family members, respectively, and although many are poorly characterized, the majority show a notable expression bias to the reproductive tract and immune tissues or are deregulated in cancers. CAP superfamily proteins are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumor suppressor or prooncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. This review describes mammalian CAP superfamily gene expression profiles, phylogenetic relationships, protein structural properties, and biological functions, and it draws into focus their potential role in health and disease. The nine subfamilies of the mammalian CAP superfamily include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. We conclude that overall protein structural conservation within the CAP superfamily results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters target specificity and, therefore, the biological consequences.
406 citations
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TL;DR: This bi-Gaussian model provides an analytical description of the predicted distributions of mutational stability effects and comprises a novel tool for analyzing proteins and protein models, for simulating the effect of mutations under evolutionary processes, and a quantitative description ofmutational robustness.
405 citations
Authors
Showing all 14460 results
Name | H-index | Papers | Citations |
---|---|---|---|
D. M. Strom | 176 | 3167 | 194314 |
Christopher M. Dobson | 150 | 1008 | 105475 |
Dario Bisello | 140 | 2005 | 107859 |
Giorgio Maggi | 135 | 1323 | 90270 |
Jörg P. Rachen | 133 | 400 | 94766 |
Pascal Vanlaer | 133 | 1270 | 91850 |
Freya Blekman | 133 | 1388 | 89808 |
Jorgen D'Hondt | 132 | 1257 | 89685 |
Tae Jeong Kim | 132 | 1420 | 93959 |
Xavier Janssen | 132 | 1309 | 86860 |
Matthias Ulrich Mozer | 131 | 1185 | 87709 |
Valery Zhukov | 129 | 1255 | 83330 |
Stephanie Beauceron | 129 | 1213 | 86374 |
Steven Lowette | 128 | 1094 | 78876 |
Yen-Jie Lee | 128 | 1247 | 82542 |