Vrije Universiteit Brussel

About: Vrije Universiteit Brussel is a education organization based out in Brussels, Belgium. It is known for research contribution in the topics: Population & Context (language use). The organization has 14295 authors who have published 38258 publications receiving 1203970 citations. The organization is also known as: VUB.

Compliant actuator designs

Abstract: In the growing fields of wearable robotics, rehabilitation robotics, prosthetics, and walking k robots, variable stiffness actuators (VSAs) or adjustable compliant actuators are being designed and implemented because of their ability to minimize large forces due to shocks, to safely interact with the user, and their ability to store and release energy in passive elastic elements. This review article describes the state of the art in the design of actuators with adaptable passive compliance. This new type of actuator is not preferred for classical position-controlled applications such as pick and place operations but is preferred in novel robots where safe human- robot interaction is required or in applications where energy efficiency must be increased by adapting the actuator's resonance frequency. The working principles of the different existing designs are explained and compared. The designs are divided into four groups: equilibrium-controlled stiffness, antagonistic-controlled stiffness, structure-controlled stiffness (SCS), and mechanically controlled stiffness.

The Interpretation of Analytical Chemical Data by the Use of Cluster Analysis

Abstract: A practical, user-oriented introduction to clustering methods, including both hierarchical and non-hierarchical methods. Shows how clustering can be used to interpret large quantities of analytical data and discusses the relation of clustering to other pattern recognition techniques. Uses a two-level approach to provide both a qualitative understanding of the philosophy, advantages, and disadvantages of clustering and a quantitative understanding for readers who want a strong mathematical background. Includes a worked example and a list of computer packages.

Activation and allosteric modulation of a muscarinic acetylcholine receptor

Abstract: Despite recent advances in crystallography and the availability of G-protein-coupled receptor (GPCR) structures, little is known about the mechanism of their activation process, as only the β2 adrenergic receptor (β2AR) and rhodopsin have been crystallized in fully active conformations. Here we report the structure of an agonist-bound, active state of the human M2 muscarinic acetylcholine receptor stabilized by a G-protein mimetic camelid antibody fragment isolated by conformational selection using yeast surface display. In addition to the expected changes in the intracellular surface, the structure reveals larger conformational changes in the extracellular region and orthosteric binding site than observed in the active states of the β2AR and rhodopsin. We also report the structure of the M2 receptor simultaneously bound to the orthosteric agonist iperoxo and the positive allosteric modulator LY2119620. This structure reveals that LY2119620 recognizes a largely pre-formed binding site in the extracellular vestibule of the iperoxo-bound receptor, inducing a slight contraction of this outer binding pocket. These structures offer important insights into the activation mechanism and allosteric modulation of muscarinic receptors.

Motor Competence and its Effect on Positive Developmental Trajectories of Health

Abstract: In 2008, Stodden and colleagues took a unique developmental approach toward addressing the potential role of motor competence in promoting positive or negative trajectories of physical activity, health-related fitness, and weight status. The conceptual model proposed synergistic relationships among physical activity, motor competence, perceived motor competence, health-related physical fitness, and obesity with associations hypothesized to strengthen over time. At the time the model was proposed, limited evidence was available to support or refute the model hypotheses. Over the past 6 years, the number of investigations exploring these relationships has increased significantly. Thus, it is an appropriate time to examine published data that directly or indirectly relate to specific pathways noted in the conceptual model. Evidence indicates that motor competence is positively associated with perceived competence and multiple aspects of health (i.e., physical activity, cardiorespiratory fitness, muscular strength, muscular endurance, and a healthy weight status). However, questions related to the increased strength of associations across time and antecedent/consequent mechanisms remain. An individual’s physical and psychological development is a complex and multifaceted process that synergistically evolves across time. Understanding the most salient factors that influence health and well-being and how relationships among these factors change across time is a critical need for future research in this area. This knowledge could aid in addressing the declining levels of physical activity and fitness along with the increasing rates of obesity across childhood and adolescence.