Showing papers in "Autoimmunity Reviews in 2005"

TL;DR: RA is considered to be a multifactorial disease, resulting from the interaction of both genetic and environmental factors, which contribute to its occurrence and expression.

TL;DR: It is shown that in a subgroup of patients with SLE, apoptotic cells accumulated in the germinal centers of the lymph nodes, and a failure of clearance in the early phase of apoptosis leads to a secondary necrotic status of the cells.

TL;DR: The characteristics, developmental pathways, and functions of regulatory T cells, as well as their role in human autoimmune diseases including multiple sclerosis, rheumatoid arthritis, Myasthenia Gravis, Kawasaki disease, autoimmune polyglandular syndrome type II, type 1 diabetes, autoimmune lymphoproliferative syndrome, and systemic lupus erythematosus are summarized.

TL;DR: A better understanding of the mechanisms underlying the induction and functions of Tr cells in controlling the immune system is critical in view of a future cellular therapy to modulate immune-mediated pathologies.

TL;DR: The result that Th1 cells are highly susceptible to the suppressive activity of Treg thymocytes is consistent with the important role of these cells in protecting against the Th1-mediated immune response to autoantigens.

TL;DR: Individuals who have SCLE skin lesions as a component of their presenting illnesses represent a distinctive subset (subphenotype) of LE that enjoys a good prognosis with respect to life-threatening systemic manifestations of LE.

TL;DR: Patients can be classified as having SLE with only skin manifestations because the current ACR classification criteria for SLE include four somewhat overlapping dermatologic criteria, butterfly rash, discoid lupus, photosensitivity, and oral ulcers.

TL;DR: This work proposes the new entity "IgG4-related plasmacytic exocrinopathy" and expects future development with regard to its relationship with autoimmune pancreatitis, which similarly presents elevated serum IgG4 levels.

TL;DR: HCQ should probably be maintained throughout pregnancy in patients with SLE and it does not seem necessary to advise against breastfeeding.

TL;DR: These disappointing results may determine controversial attitude in the long-term treatment with anti-TNF agents in RA or Crohn's disease.

TL;DR: The authors showed that TGF-β deficiency may induce autoimmune disease by influencing a number of immunological phenomena including lymphocyte activation and differentiation, cell adhesion molecule expression, regulatory T cell function, the expression of MHC molecules and cytokines, and cell apoptosis.

TL;DR: Altered functioning of the HPA axis (early morning reduced corticosteroid production) and of the pineal gland found in RA patients, seem to be important factors in the appearance and perpetuation of the clinical circadian symptoms of the disease.

TL;DR: The predisposition of certain HLA genotypes to AIH as well as the clonal expansion of a limited number of T cell receptors suggests that the presentation of a self-antigen or a molecular mimic may be responsible for the initiation of the immune response.

TL;DR: The NOD mouse has been an important model of type 1 diabetes and autoimmune diseases for over 20 years and demonstrates a broad susceptibility to multiple autoimmune syndromes, due to defects in both central and peripheral tolerance.

TL;DR: Interestingly, absence or extremely low concentration of serum MBL (MBL deficiency) seems to be a risk factor for occurrence of autoimmune diseases, in particular systemic lupus erythematosus and atherosclerosis and arterial thrombosis.

TL;DR: At equimolar doses of Hg, MeHg has the weakest immunostimulating, autoimmunogen, and IC-inducing effect, while the effect of thimerosal is similar to that of inorganic mercury.

TL;DR: This review surveys the actual data concerning the role of the humoral immune system in MS and EAE and explains potential modes of action and long-time persistence in the inflamed brain tissue as a B cell-supportive microenvironment in MS.

TL;DR: Analysis of the immunogenicity of NT-carrying self-proteins has revealed that they elicit both humoral and cellular immune responses in mice, suggesting that NT-containing epitopes created on self- Proteins may serve as a trigger to impair or bypass immunological tolerance.

TL;DR: Targeting MC development, maturation or activation may be of value in future prevention and treatment of autoimmune conditions.

TL;DR: The isomorphic response of Koebner can be observed not only in psoriasis, but also in other diseases, such as lichen planus and some systemic diseases including LE (lupus erythematosus) or sarcoidosis.

TL;DR: A major working hypothesis for the first step in the mechanism of drug-induced autoimmunity is that the drug must irreversibly bind to some structure, or more commonly a reactive metabolite of the drug, which results in the production of antibodies or T-cells directed against the altered structure.

TL;DR: The role of CD20 antigen in B cell function and the effectiveness and limits of passive immunotherapy with anti-CD20 monoclonal antibody (Rituximab) in the treatment of autoimmune (or immune-mediated) diseases are reviewed.

TL;DR: The recognized association of specific systemic autoimmune diseases with HCV infection, added to the possible evolution of any one of these entities into a B- cell NHL, suggests the possibility of a close relationship among SS, HCV and B-cell lymphoproliferative disorders, especially in patients with type II mixed cryoglobulinemia.

TL;DR: The association of NPSLE with the anti-phospholipid syndrome, other autoantibodies and inflammatory cytokines have also provided clues to the diagnosis and pathophysiology.

TL;DR: It is suggested that ACPA may be found in some patients with other rheumatic autoimmune diseases, including psoriatic arthritis, systemic lupus erythematosus and Sjögren's syndrome.

TL;DR: Certain serious, but uncommon, adverse events have been observed with all three TNF(alpha) blocking agents, including serious bacterial infections, tuberculosis (TB) and certain opportunistic infections, demyelinating syndromes, and lupus-like reactions, and data suggest that these adverse reactions may be related to blockade of TNF (alpha) and may therefore represent class effects of these agents.

TL;DR: A pathogenic model where both the onset and aggravation of nephritis are promoted by an imbalance of immune response towards a T helper 1 cytokine predominance due to IL-18 up-regulation is hypothesized, which may possibly prevent the development of renal disease.

TL;DR: The clinical features, diagnosis, therapy, and prognosis of NLE are discussed, and a summary of experimental data relating to pathogenesis is presented.

TL;DR: Although speculative, mononuclear cell responses against biliary epithelial cells may create a persistent inflammatory response, eventually leading to fibrosis.

TL;DR: The analysis of MRL/lpr mice showed a close association between immunoglobulin deposits and the appearance of skin lesions, and the model of drug- induced cutaneous LE can yield additional insight since the trigger is clear in drug-induced LE.