Alakananda Basu

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: This paper summarizes the current understandings regarding the mechanisms by which cisplatin induces cell death and the bases of cis Platin resistance, and discusses various steps, including the entry of cis platin inside cells, DNA repair, drug detoxification, DNA damage response, and regulation of cisPlatin-induced apoptosis by protein kinases.

TL;DR: This review focuses on the regulation of autophagy by several kinases with particular emphasis on serine/threonine protein kinases such as mTOR, AMP-activated protein kinase, Akt, mitogen-activatedprotein kinase (ERK, p38 and JNK) and protein Kinase C that are often deregulated in cancer and are important therapeutic targets.

TL;DR: Rottlerin, a selective inhibitor of novel PKCδ, blocked activation of caspases, proteolytic activation of PKC δ and cell death induced by cDDP, and acts at an early stage of the cD DP-induced cell death pathway that precedes caspase activation.