Showing papers in "Clinical Therapeutics in 2002"

TL;DR: Although various means to reduce the immunogenicity of therapeutic proteins have been suggested, monitoring for antibodies during clinical trials and postmarketing surveillance remains an important issue for all therapeutic proteins

TL;DR: The results of this meta-analysis demonstrate that with antihypertensive medications, QD dosing regimens are associated with higher rates of adherence than either BID or MDD regimens.

TL;DR: Current data on TDM of the following immunosuppressant drugs used in organ transplantation are summarized, and recent findings indicate that monitoring of drug levels 2 hours after dosing is a more sensitive predictor of outcome than trough (C0) monitoring.

TL;DR: IBS is associated with impairment of HRQoL relative to US population norms and to populations with GERD, asthma, or migraine, and appears to be greater in patients with IBS than in those with panic disorder or rheumatoid arthritis.

TL;DR: In a managed care organization, previously treated patients receiving monotherapy with an oral antidiabetic medication who required additional therapy exhibited significantly greater adherence when they were switched to fixed-dose combination therapy compared with combination therapy.

TL;DR: When once-weekly alendronate 70 mg was compared with once-daily alendRONate 10 mg in this study, 70-mg once- weekly alendronsate was the preferred dosing regimen.

TL;DR: Treatment with piog litazone was associated with greater beneficial effects on blood lipid levels than treatment with rosiglitazone, whereas glycemic control was equivalent between the 2 treatments.

TL;DR: In this study, 0.5% fluorouracil cream once daily was at least as effective as 5% fluoride cream twice daily in terms of the percent reduction in AK lesions and total clearance ofAK lesions; it was more effective than the 5% cream in reducing the absolute number of AK lesions from baseline.

TL;DR: The results of clinical trials suggest the efficacy of tenofovir DF in reducing plasma levels of HIV-1 RNA when used as an add-on to a stable antiretroviral regimen and pharmacokinetic and efficacy studies in children are ongoing.

TL;DR: Once-weekly dosing with either of the pegylated IFNs was more effective than the respective thrice-weekly regimen of IFN alfa, with a comparable safety profile, and the combination of once-weekly pegylation IFN and ribavirin effectively reduced HCV viral load and sustained viral suppression.

TL;DR: In the acute treatment of Anthonisen type 1 AECB, a 5-day course of gemifloxacin was at least as effective as a 7-day regimen of clarithromycin in patients with an acute exacerbation of chronic bronchitis.

TL;DR: The risk of abacavir HSR must be taken into consideration when selecting initial antiretroviral therapy for patients with HIV infection and is necessary to rule out an HSR and determine whether the medication can be continued.

TL;DR: The only characteristics identified as prognostic factors for hypersensitivity reaction to abacavir were antiretroviral treatment status and black race, each resulting in a lower rate compared with the expected incidence.

TL;DR: The results of clinical trials suggest that caspofungin is effective in the treatment of esophageal and oropharyngeal candidiasis and invasive aspergillosis and when combined with other antifungal agents, casp ofungin produces a synergistic or additive effect against a variety of clinically important fungi.

TL;DR: Understanding the seasonal incidence of rhinovirus infection may help determine how best to employ currently available antirhinoviral agents in patients presenting with symptoms of an acute viral respiratory infection.

TL;DR: Greater reductions in the severity of acne were observed in the physician's and patient's Clinical Global Improvement scale scores and in other secondary efficacy measurements, and reductions in total acne lesions were significantly reduced after 16 weeks of treatment with combination gel compared with clindamycin monotherapy.

TL;DR: These data indicate that patients receiving topiramate experience body weight loss and a reduction in BMI, which may promote long-term adherence to treatment among psychiatric patients and possibly decrease the medical risks associated with obesity.

TL;DR: Tramadol/acetaminophen was significantly superior to placebo on the patients' and physicians' overall assessments of medication and on 3 of 4 subscales of the Western Ontario and McMaster Universities Osteoarthritis Index Questionnaire.

TL;DR: Assessment of patients' persistence with antihypertensive drug therapy in a nonexperimental setting found patients initially prescribed AIIAs were more likely to continue treatment than those initiated on other types ofAntihypertensives (P < 0.001).

TL;DR: In the patients with type 2 diabetes studied, an inhaled insulin regimen with the need for only 1 subcutaneous injection at bedtime appeared to offer more ease of use, comfort, and convenience, as well as greater overall satisfaction, than aSubcutaneous insulin regimen of 2 to 3 injections daily.

TL;DR: This 6-month, open-label, noncontrolled study showed LA-2500 7.5-mg depot was well tolerated and maintained testosterone suppression (< or = 50 ng/dL) in the patients completing the study without any testosterone breakthrough responses.

TL;DR: Premeal injection of BIAsp 30 in a twice-daily regimen significantly reduced overall postprandial glucose excursions, and both insulins were associated with < or = 7 minor and no major hypoglycemic events.

TL;DR: In this study in hospitalized patients with moderate to severe CAP, levofloxacin monotherapy was at least as effective as a combination regimen of azithromycin and ceftriaxone in providing coverage against the current causative pathogens in CAP.

TL;DR: T/APAP tablets provided effective, rapid, and dose-dependent analgesia for the treatment of postoperative dental pain in adults with at least moderate pain after extraction of > or =2 impacted third molars.

TL;DR: In this paper, the authors examined the factors involved in relapse to smoking in patients who had successfully stopped smoking using bupropion SR and found that craving was cited most frequently as a factor contributing to relapse.

TL;DR: The findings of this study support the efficacy and tolerability of enteric-coated fluoxetine 90 mg given twice during the luteal phase of the menstrual cycle for the treatment of PMDD.

TL;DR: When administered at OTC doses, naproxen was effective in the relief of pain and other symptoms of primary dysmenorrhea and had a good safety profile in the population studied.

TL;DR: The findings of this analysis suggest that bupropion SR may be an appropriate therapeutic option in normal-weight or overweight patients with depression who are concerned about weight gain.

TL;DR: The overall analgesic efficacy, as assessed by TOPAR8, of a single doses of rofecoxib 50 mg was significantly greater than a single dose of enteric-coated diclofenac sodium 50 mg, and placebo over 8-hour and 24-hour periods in patients with moderate to severe pain after oral surgery.