Showing papers in "Developmental Brain Research in 1995"

TL;DR: In addition to its temporal and spatial regulation nestin expression appears to be regulated at the level of subcellular mRNA localization: in columnar neuroepithelial and radial glial cells nestin mRNA is predominantly localized to the pial endfeet.

TL;DR: The findings suggest that these two major dopamine target regions follow different developmental strategies, and this has implications for etiological theories of schizophrenia that focus on anomalous receptor pruning.

TL;DR: The effect of prenatal stress on HPA function is substantially more marked in females than in males, and a similar pattern of effects on H PA activity has been reported for prenatal alcohol exposure.

TL;DR: A minor band was shown to be identical to GDNF in the mature peptide sequence, but which has a 78 base pair deletion in the preproprotein sequence, and is observed in the predicted RT-PCR product.

TL;DR: Intense microglial expression occurs after neonatal HI either with an acute or delayed time-course depending on brain region, and is seen in most injured regions with exception of the thalamus where a delayedmicroglial response was seen.

TL;DR: It is suggested that BDNF has a direct effect on mature cerebellar granule neurons and can protect these neurons from apoptosis in low K+.

TL;DR: The present results suggest that guiding cues of the radial migration of mesencephalic DA neurons represent processes of radial glial cells which express tenascin and tangentially arranged nerve fibers originating from the lateral part of the Mesencephalon may provide a scaffolding along which the mesENCEphalicDA neurons subsequently migrate laterally to form the ventral tegmental area and the substantia nigra.

TL;DR: Differences in abundance developmental profiles, and regulation imply distinct functions for each factor in the visual system, which differentially modulated expression of NGF and BDNF mRNA's.

TL;DR: Findings suggest that MK is produced around the site of nerve damage and plays a role as a reparative neurotrophic factor during the early phase of cerebral infarct.

TL;DR: Properties of low Mg2+ induced epileptiform activity were studied in isolated rat hippocampal slices or in combined slices containing the entorhinal cortex and hippocampus and seizure-like events were observed in all age groups.

TL;DR: It is revealed that olfactory stimulation alone does not alter extracellular norepinephrine levels, and infusion of potassium into the bulb on PND 3 produces a rapid increase in NE, indicating a local neuronal origin of the NE in response to stimulation.

TL;DR: It is reported that neonatal BDV infection interfered with cerebellar development in the Lewis rat, and persistentBDV infection of Purkinje cells, but not granule cells, was associated with loss of granules cells during cerebellary development, in the absence of encephalitis.

TL;DR: Data identify the atria as a prominent site of fetal A1AR expression and show that the A1 AR gene is one of the earliest expressed G protein-coupled receptor genes in the heart.

TL;DR: The results suggest that estrogen induction of dendritic spines in the VMN and CA1 is dependent on organizational effects of gonadal steroids.

TL;DR: The results show that the deep cerebellar nuclei are sufficient for motor learning, provided the task is not too difficult (20 rpm), but that the Cerebellar cortex is required when thetask is more difficult (30 rpm).

TL;DR: The brain penetration of 14C-mannitol was investigated using a bilateral in situ brain perfusion technique followed by capillary depletion analysis, and unlike mannitol the K(in) was greater in the neonate compared to the adult suggesting an elevated rate of transfer for this amino acid into the neonatal rat brain.

TL;DR: The very early expression of PGP9.5 suggests that there is a role for ubiquitin hydrolases in the differentiation of neurone precursors as well as in the differentiated neurone.

TL;DR: BDNF is trophic for striatal DARPP-32-containing neurons in vitro by enhancing the survival, morphological differentiation and resistance to excitotoxicity, and its mechanisms of action are probably different from those of PDGF-BB.

TL;DR: Estrogen, derived from the local aromatization of circulating testosterone, down-regulates ER mRNA in the neonatal male preoptic area, suggesting that down-regulation of ER mRNA may be an important estrogen-regulated event in the process of sexual differentiation of the pre optic area.

TL;DR: It would appear that in addition to sharing a similar time course of onset and a sex dependent expression of obesity, both of these models are also characterized by elevated medial hypothalamic NE, which has been shown to elevate food intake and body weights in rats.

TL;DR: Disruptions in the time course of attaining developmental milestones in coloboma mutants are demonstrated and provide further evidence supporting the hypotheses that alterations in Snap gene expression are associated with functional behavioral consequences in developing offspring.

TL;DR: The data suggest that the TGF-alpha/EGF-R signaling pathway is involved in postnatal mitogenic events in the brain.

TL;DR: Major functional determinants of GABAA-receptors in granule cells (subunit repertoire, subcellular segregation and clustering in post-synaptic sites) develop in vitro, indicating that they are regulated to a large extent by intrinsic factors, independently of GABAergic input.

TL;DR: High levels of MMP-9 were expressed by progenitor cells in close association with the development of structures, such as the hypophysis, the choroid plexus, the ganglion cell layer of the retina and the uveal tract, in the first report on the localization of M MP-9 in developing neural tissues.

TL;DR: The temporal expression of the erythroid-type glucose transporter Glut 1 in the telencephalon of the embryonic and newborn mouse suggests that the bbb is established very early in CNS development, probably in the course of intraneural neovascularization.

TL;DR: Rats treated with ATD in both pre- and postnatal periods showed 'bisexual' partner preference behavior and appeared to have 59% more vasopressin-expressing neurons in the SCN than the controls, which supports the hypothesis that the increased number of vasopressing neurons found earlier in theSCN of adult homosexual men might reflect differences that took place in the interaction between sex hormones and the brain early in development.

TL;DR: It is reported here that EB exposure on day 17 masculinized (increased) the number of neurons in the HVC at day 35 that were labeled by [3H]thymidine injections on days 15/16, implying estrogenic regulation of post-mitotic events.

TL;DR: The differential expression between SCG10 and GAP-43 in later developmental stages suggests their diverse functions, which indicates these proteins may play different roles during postnatal brain development.

TL;DR: It is demonstrated that SS has a neurotrophic effect on neurite production, including initiation of neurite outgrowth, but no effect on neuronal survival, cell proliferation, or phenotype differentiation (glutaminase expression), and support the possibility that SS plays a role in the differentiation of immature cerebellar granule cells during central nervous system development.

TL;DR: The p75 nerve growth factor receptor paralleled choline acetyltransferase activity which has previously been reported to be high in the cerebellum during late foetal development and to fall in adulthood.