Showing papers in "European Journal of Cell Biology in 2013"

TL;DR: Adipogenesis is the process during which fibroblast like preadipocytes developed into mature adipocytes, a well-orchestrated multistep process that requires the sequential activation of numerous transcription factors, including the CCAAT/enhancer-binding protein (C/EBP) gene family and peroxisome proliferator activated receptor-γ (PPAR-γ).

TL;DR: Gene-targeting studies of Rho and its effectors have now unraveled their tissue- and cell-specific roles and provide deeper insight into the physiological function of RHo signaling in vivo.

TL;DR: An overview of the role of miR-29 family in the pathophysiologic changes of cancer cells and the epigenetic and immune regulation through the biological function of mi R-29s is provided.

TL;DR: The present review covers the diverse functions of this master transcriptional regulator as well as illustrates the redundant and distinct functions of its two mammalian isoforms.

TL;DR: This review focuses on the molecular mechanisms by which actin binding proteins integrate actin dynamics, mechanotransduction and integrin activation to control force transmission in focal adhesions.

TL;DR: This review focuses on the properties of miR-205 in cancers to shed light on better management of various fatal malignancies and discusses epigenetics that may account for the fluctuation of mi R-205 expression.

TL;DR: A powerful armory of molecular genetic techniques that have been continuously expanded over the years and a well curated genome sequence, which is accessible via the online database dictyBase, considerably strengthened Dictyostelium's experimental attractiveness and its value as model organism.

TL;DR: Key functions of decorin such as interaction with cell surface receptors, as well as with ECM components, and the therapeutic potential of this multifunctional molecule are highlighted.

TL;DR: It is proposed that PAK4 should be considered a signalling integrator regulating numerous fundamental cellular processes, including actin cytoskeletal dynamics, cell morphology and motility, cell survival, embryonic development, immune defence and oncogenic transformation.

TL;DR: The guardians of monomeric actin keep the volatility of actin in check, so that its explosive power is only released in the controlled environments of the nucleation and polymerization machineries.

TL;DR: These results provide evidence for mechanotransduction at the scale of individual filaments, showing that forces participate in the regulation of filament assembly and organization and bring insight into the elementary events coupling mechanics and biochemistry in cells.

TL;DR: It is found that these TIP47 mutants lacking the binding site for Rab9 misdirect the de novo synthesized viral particles to the autophagosomal/lysosomal compartment where the particles are degraded.

TL;DR: It is demonstrated that epigenetic modifying drug BIX-01294 is able to increase the ability of AdMSCs to differentiate into ECs engaging DNA and histone methylation and might serve as a simple tool to increased the differentiation potential of Ad MSCs.

TL;DR: The results suggest that, in addition to enteric smooth muscles, γ-SMA is expressed in all the tissues submitted to an important dilation including veins, gravid uterus, and lactating mammary glands.

TL;DR: This is the first study to show that STAT3 deficiency leads to a disruption of mitochondrial ultrastructure and increased autophagy, and the results demonstrate that the HL-1 STAT3 KD cell line is a good model to study cellular consequences ofSTAT3 deficiency.

TL;DR: This review will point out how physics can improve, break-down or support classical approaches to examine tumor growth even across primary tumor boundaries, the invasion of single or collective cancer cells, transendothelial migration of cancer cells and metastasis in targeted organs, and show how physical measurements can be integrated into classical tumor biological analysis approaches.

TL;DR: A role for cell surface MUC16 in cell-cell adhesion of epithelial cancer cells is suggested, and its interaction with Src family kinases may enhance SFKs-induced deregulation of E-cadherin.

TL;DR: It is demonstrated that breast cancer cells are sensitive to the chemotherapeutic agent dox irrespective of Survivin and XIAP expression levels, and the findings suggest that dox-mediated modulation of SurvivIn and XI AP might sensitize cells to taxanes when used in a sequential regimen.

TL;DR: The results showed for the first time, that IL-10 modulated oxLDL-induced apoptosis by upregulating SOCS3, which then interrupted p38 MAPK activation in endothelial cells.

TL;DR: Epistasis analyses with mutants in cell wall integrity (CWI) signaling confirm that the SNF1 complex and the CWI pathway independently affect yeast cell integrity.

TL;DR: The results show that GlcNAc β1,6 N-glycosylation of cell surface receptors, which increases with the aggressiveness of melanoma cells, is an important factor influencing melanoma cell migration.

TL;DR: It is shown for the first time that extracellular matrix degradation by invadopodia can be differentially manipulated, without effects on cell proliferation, by use of metabolic inhibitors or changes in nutrient composition of cell culture media.

TL;DR: Using structured illumination microscopy together with advanced spinning disk confocal microscopy it is shown that Drosophila pupal macrophages provide a powerful system for single gene analysis that allows forward genetic screens to characterize the regulatory network controlling cell shape and directed cell migration in a physiological context.

TL;DR: S sustained expression of some components of MAPK signaling pathway in primary chicken embryo dermal myofibroblasts results in a loss of autocrine TGF-β signaling and suppression of the myofIBroblastic phenotype, characterized by the loss of alpha smooth muscle actin fibers and a substantial reduction in the production of extracellular matrix.

TL;DR: It is reported here that osteoclast differentiation is a podosome-independent process and the great capacity of myeloid cells to adapt to the different environments they encounter during their life cycle is illustrated.

TL;DR: It is suggested that ASP, especially at high physiologic doses, may stimulate specific inflammatory cytokines in adipocytes through PI3kinase- and NFκB-dependant pathways, thus further promoting macrophage infiltration and local inflammation in obese adipose tissue.

TL;DR: Resveratrol-induced AMPK suppression and activation, possibly through the modulation of SIRT protein activity, may be related to the inhibition and promotion of mitochondrial and autophagic functions, leading to cell death and survival in undifferentiated and differentiated cells, respectively.

TL;DR: The results strongly suggest that, among other complementary cell guidance factor(s), the chemotactic response of NCCs toward the ocular region NT-3 gradient is essential for spatiotemporal cell orientation, amplifying the functional scope of this neurotrophic factor as a molecular guide for the embryo cells, besides its well-known canonical functions.

TL;DR: It is concluded that mitochondria readily fuse in green algae.

TL;DR: Data indicate that a combined application of Sorafenib and interferon α in order to obtain an antiviral effect is not useful since SorAFenib exerts an inhibitory effect on targets that are crucial for the transduction of interferons α-dependent antiviral response.