Carmela Fimognari

TL;DR: This review provides a roadmap for the design of successful anti-cancer strategies that overcome resistance to apoptosis for better therapeutic outcome in patients with cancer.

TL;DR: SFN can be viewed as a conceptually promising agent in cancer prevention and/or therapy because of its ability to simultaneously modulate multiple cellular targets involved in cancer development.

TL;DR: Findings indicate that sulforaphane but not the native GL GRA can exert both protective and toxic effects inhibiting leukemic cell growth and deserves study as a potential chemopreventive/chemotherapeutic antileukemic agent.

TL;DR: An international task force of 180 scientists was assembled to explore the concept of a low-toxicity "broad-spectrum" therapeutic approach that could simultaneously target many key pathways and mechanisms, and results suggest that a broad-spectrums approach should be feasible from a safety standpoint.

TL;DR: It is demonstrated for the first time that ferroptosis is immunogenic in vitro and in vivo, and thus broadens the current concept of immunogenic cell death and opens the door for the development of new strategies in cancer immunotherapy.