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Journal ArticleDOI

Effect of side-chain shortening on the physiologic properties of bile acids: Hepatic transport and effect on biliary secretion of 23-nor-ursodeoxycholate in rodents

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TLDR
It is proposed that a fraction of nor-UDC is secreted into canalicular bile in the unconjugated form and is protonated by a hydrogen ion derived from carbonic acid that was generated by the hydration of luminal CO2 by carbonic anhydrase present in biliary ductular cells.
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This article is published in Gastroenterology.The article was published on 1986-04-01. It has received 231 citations till now. The article focuses on the topics: Bile acid & Biliary fistula.

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Journal ArticleDOI

Bile Acids: Chemistry, Pathochemistry, Biology, Pathobiology, and Therapeutics

TL;DR: The great variety of bile acids and bile alcohols that are present in vertebrates are tabulated and signaling molecules, activating nuclear receptors in the hepatocyte and ileal enterocyte, as well as an increasing number of G-protein coupled receptors are identified.
OtherDOI

Bile formation and secretion.

TL;DR: Canalicular bile secretion is determined by both bile salt-dependent and independent transport systems which are localized at the apical membrane of the hepatocyte and largely consist of a series of adenosine triphosphate-binding cassette transport proteins that function as export pumps for bile salts and other organic solutes.
Journal ArticleDOI

Metabolic zonation of the liver: regulation and implications for liver function.

TL;DR: Current knowledge about this heterogeneity of the hepatocytes along the porto-central axis, its development and determination, as well as about its significance for the understanding of all aspects of liver function and pathology are summarized.
Journal ArticleDOI

Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver.

TL;DR: Bsep is identified as an important target for induction of drug- and estrogen-induced cholestasis in mammalian liver through ATP-dependent taurocholate transport in cLPM vesicles.
Journal ArticleDOI

Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: A placebo‐controlled trial

TL;DR: It is concluded that ursodeoxycholic acid is beneficial in reducing disease activity in patients with primary sclerosing cholangitis and histopathological features improved significantly, as evaluated by multiparametric score.
References
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Journal ArticleDOI

A new enzymatic method for determination of serum choline-containing phospholipids

TL;DR: The method affords better specificity, requires a smaller quantity of the sample and shorter time than those previously reported, and has excellent precision.
Journal ArticleDOI

The influence of bile salt structure on self-association in aqueous solutions.

TL;DR: The results indicate that the concentration at which bile salt aggregation occurs varies widely and is determined not only by the number, type, and orientation of nuclear substituents, but also by side chain structure.
Journal ArticleDOI

Re-evaluation of the 3 alpha-hydroxysteroid dehydrogenase assay for total bile acids in bile.

TL;DR: It was established that the bile acid concentration in bile samples with a high molar percentage of cholesterol would be overestimated if 3 beta-hydroxysteroid dehydrogenase were present with the 3 alpha-enzyme.
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Physicochemical properties of bile acids and their relationship to biological properties: an overview of the problem.

TL;DR: The structure of the bile acid molecule is described and correlated with physiochemical properties of bile acids such as solubility, ionization, and micelle formation, and recent measurements of the critical micellar concentration indicate that the CMC is influenced by both side chain and nuclear structure.
Journal ArticleDOI

Characterization of the kinetics of the passive and active transport mechanisms for bile acid absorption in the small intestine and colon of the rat

TL;DR: Determination of the passive permeability coefficient for ionized monomers demonstrated that permeability decreased by a factor of 3.4 for the addition of a hydroxyl, glycine, or taurine group to the steroid nucleus.
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