Showing papers in "International Journal of Mass Spectrometry in 2021"

TL;DR: The Dragonfly Mass Spectrometer (DraMS) as discussed by the authors is one of the key analytical instruments onboard the Dragonfly lander that will perform detailed chemical analyses of the Titan surface and atmosphere.

TL;DR: In this article, the authors presented a novel native capillary isoelectric focusing (cIEF)-assisted CZE-MS method for the characterization of monoclonal antibodies (mAbs) with much larger sample loading capacity and significantly better separation resolution.

TL;DR: In this paper, a modified Orbitrap Exploris instrument with improved pumping allowed isotopic resolution of intact monoclonal antibodies even when using standard nitrogen supply in the Ion Routing Multipole.

TL;DR: In this paper, a minireview describes the unique reactivities in microdroplets and acceleration mechanisms with examples of experimental and theoretical studies, as well as various methods for scale-up of microdroplet reactions and the accelerated derivatization for in-situ molecular analysis.

TL;DR: It is shown that online SEC coupling can also serve as the basis for multidimensional non-denaturing liquid chromatography workflows, with the SEC acting as a fast desalting device, helping to achieve first dimension LC separation in optimal chromatographic conditions while being compatible with further nMS analysis.

TL;DR: In this article, the authors demonstrate the integration of travelling wave ion mobility spectrometry (TWIMS) into the native nano-DESI MSI workflow, which enables the calculation of collision cross sections, and thus a measure of protein structure directly from the imaging dataset.

TL;DR: Using native mass spectrometry, a novel data analysis strategy is developed to deconvolve zinc and lipid bound to the proteoforms of rhodopsin and investigated the allosteric interaction between lipids and zinc binding, revealing that lipid binding can be strongly and differentially influenced by metal ions.

TL;DR: In this paper, the history, applications, and outlook of a unique methodology, field-induced droplet ionization mass spectrometry (FIDI-MS), are discussed.

TL;DR: In this article, an improved peak detection algorithm combing continuous wavelet transform and image segmentation was proposed, where the ridges in wavelet space that correspond to peaks positions were completely identified by a new searching method named stair scanning.

TL;DR: In this article, the authors developed a highly sensitive method for the determination of free cyanide (CN−) in drinking water using derivatization and liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS).

TL;DR: In this paper, electrostatically reactive, gas-phase ion/ion chemistry and IM-MS are combined to characterize the structural changes between ubiquitin electrosprayed from aqueous and denaturing conditions.

TL;DR: Ion-Laser Interaction Mass Spectrometry (ILIAMS) was proposed in this article to improve the sensitivity and efficiency for the detection of this isotope in artificial and environmental samples.

TL;DR: In this paper, positively charged cluster ions of phosphorus were formed upon electron ionization of doped helium nanodroplets, and they exhibited odd-even oscillations that were opposite to almost all experimental and theoretical patterns published in the literature.

TL;DR: In this paper, the abundant fragments of 22 illegal drugs and seven explosives were analyzed successfully using resonance excitation with a miniaturized ion trap mass spectrometer constructed in our laboratory and coupled with flash-thermal-desorption acetone-assisted photoionization.

TL;DR: In this article, a miniature dielectric barrier discharge (m-DBD) ionization source was developed, and a comparative study of dc corona, ac corona and the mDBD ionization in ambient air was made.

TL;DR: In this article, the effects of the collisional dissociation of solvent-related species are investigated as a source of variability in IR measurements, and the quadrupole band-pass filter used in the ThermoScientific Q Exactive Focus is investigated for its transmission properties along with the effect of the transmission window on IR accuracy and precision.

TL;DR: In this article, a state-of-the-art ab initio molecular dynamics (AIMD) simulation is performed to study the bimolecular collision of HCl+Cl+HCl.

TL;DR: This tutorial offers a decision-tree for the analysis of nTDMS experiments on protein complexes and diverse bioassemblies, and includes an overview of strategies to navigate this type of analysis, and highlights software for the hypothesis-driven interrogation of fragment ions for localization of PTMs, metals, and cofactors on native proteoforms.

TL;DR: In this article, an appropriate labeling system for IMS is proposed, requiring that at least the temperature, gas, electric field, and instrument employed are provided and which is an extension of the previous protocol.

TL;DR: A simulation approach is presented able to predict the IDMS calibration curves and estimate the errors that are introduced by the linear simplification, and can be a valuable tool to plan IDMS experiments and to assess if a linear model is fit for purpose.

TL;DR: In this paper, the protonated cyclo (LTyr-LPro) and cyclo dipeptides based on a diketopiperazine (DKP) ring are studied by tandem mass spectrometry in a Fourier transform ion cyclotron resonance (FT-ICR) mass analyzer.

TL;DR: In this article, the thermal decomposition of allyltrichlorosilane and allymptotically-stable allyl-trimethylsilane at temperatures up to 1340 K were studied using flash pyrolysis coupled with molecular beam sampling and vacuum ultraviolet single-photon ionization time-of-flight mass spectrometry (VUV-SPI-TOFMS).

TL;DR: In this article, single-layer graphene oxide (SLGO) was adsorbed on a conductive glass surface to prepare a uniform thin film, which was used as the pre-coated matrix in matrix assisted laser desorption ionization-mass spectrometry (MALDI-MS) imaging to avoid the need of a matrix cover.

TL;DR: In this article, a model peptide, bradykinin, and a model oligosaccharide, κ-carrageenan with a degree of polymerization of 4, were fragmented using a variety of charge transfer dissociation mass spectrometry (CTD-MS) reagent gases, which included helium, hydrogen, oxygen, nitrogen, argon and lab air.

TL;DR: In this article, a multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS) was used to measure uranium isotope ratios in Fukushima microwave-digested soil samples.

TL;DR: In this paper, the feasibility of using native mass spectrometry (MS) as a means of studying interactions of neutrophil elastase with heparin oligomers was evaluated.

TL;DR: In this article, the authors discuss and propose optimal conditions for precise and accurate Eu isotope ratio measurements in geological materials (igneous rock samples) using MC-ICP-MS.

TL;DR: In this article, the ability of an unmodified ESI Z-spray source to carry out ambient ion soft landing (AISL) and microdroplet reactions (MR) was tested.

TL;DR: In this paper, the integration process of a higher-order multipole differential mobility spectrometer in the first vacuum stage of a mass spectrometers is described and separation of ions under the influence of a pair of antiphase asymmetric rectangular RF waveforms is demonstrated experimentally.

TL;DR: In this paper, a new technique for removal of ionized molecules prior to their extraction out of the stopping cell has been developed, which utilizes the RF carpet for the separation of atomic ions from molecular contaminant ions through their difference in ion mobility.