Showing papers in "Journal of Clinical Neuroscience in 2020"

TL;DR: The symptoms of Guillain Barre syndrome (GBS) are described in one infected patient with COVID-19, for the first time, and electrodiagnostic test showed that the patient is an AMSAN variant of GBS.

TL;DR: It is noted that sometimes the neurological manifestations can precede the typical features like fever and cough and later on typical manifestations develop in these patients, hence a high index of suspicion is required for timely diagnosis and isolation of cases to prevent the spread in neurology wards.

TL;DR: A review of the historical association between neurological complications and highly pathological coronaviruses including SARS, MERS and COVID-19 draws from evidence derived from past coronavirus outbreaks, noting the similarities and differences between SARS and Mers and the current CO VID-19 pandemic.

TL;DR: It is suggested that ischemic cerebrovascular diseases may simultaneously develop in the course of Covid-19 independently of the critical disease process and increased inflammation predicted by CRP and D-dimer levels may play a role in the formation of ischemia.

TL;DR: This case of facial diplegia after 10 days of SARS-CoV-2 confirmed infection symptoms in a 61 year old patient is proposed as a rare variant of GBS in COVID-19 infection context, due to Its chronology, clinical manifestations and cerebrospinal fluid (CSF) findings.

TL;DR: The level of anxiety experienced by healthcare workers employed in COVID-19 services, the effects of anxiety on sleep quality and quality of life and, the relationship between these variables and problem-solving skills of the healthcare workers are investigated are investigated.

TL;DR: A case of a 62-year old female who was admitted due to cough, colds and shortness of breath of 2 weeks duration and was tested to be COVD-19 positive and suffered from an ischemic stroke while in the Medical Intensive Care Unit is presented.

TL;DR: A moderate burnout rate and a paradoxically high career satisfaction rate among neurosurgery residents are reported, which may help to formulate interventions to mitigate burnout and improve career satisfaction among residents.

TL;DR: These stand as a promising area of enquiry to further the authors' understanding of the pathophysiology of the disease and offer potential to be utilized as an early diagnostic biomarker or marker of disease progression.

TL;DR: It is proposed that hypothalamic inflammation represents an interconnection between somatic diseases and depressive disorder, and these assumptions are discussed in this mini-review in the light of available data from studies focusing on hypothalamicinflammation.

TL;DR: The efficacy and safety of first-line and emerging antidepressants (anti-inflammatory drugs and ketamine) were estimated by comparing the OR values and 69 SNPs associated with depression were found through reading the literature.

TL;DR: A drastic fall in the number of surgeries performed during the COVID-19 pandemic will result in large backlog of patients waiting for ‘elective’ surgery and there is a risk of these patients presenting at a later stage with progressed disease.

TL;DR: A patient affected by Covid-19 acute respiratory distress syndrome with a cerebral nervous system vasculitis triggered by SARS-Cov-2 is described at the University hospital, in Novara, Italy in the area most impacted by the pandemic.

TL;DR: CFR-PEEK implants constitute a feasible and effective way to restore stability in metastatic spine tumors and find a non inferior favorable profile in terms of intraoperative and postoperative complications and functional recovery, compared to titanium.

TL;DR: Frailty is associated with increased odds of major post-operative complication, discharge to destination other than home, 30-day readmission, and 30- day mortality after elective craniotomy for brain tumor resection.

TL;DR: Adjuvant autologous dendritic cells pulsed with tumor-lysate following resection and Gliadel Wafer placement is safe, elicits modest immunogenicity and shows similar clinical outcomes in patients who had DC vaccination in previous studies.

TL;DR: It is suggested that miR-149-5p could play a regulatory role in neuronal cell death via Sirt1/p53 axis, which offers a new target for novel therapeutic interventions during acute ischemic stroke.

TL;DR: Clinical and imaging parameters were retrospectively investigated in 147 newly diagnosed CSDH lesions in 114 patients surgically treated at the Keio University Hospital during a 6-year period to detect imaging parameters that could indicate the risk for CSDH recurrence by using quantitative volumetric analysis and computed tomography texture analysis.

TL;DR: Overall, male neurosurgeons receive significantly more total NIH grant funding than their female counterparts, except at the level of associate professor where women were found to surpass men.

TL;DR: Monitoring coagulopathy is important in COVID-19 patients and in case of venous thromboembolism, including cerebral venous system, appropriate anticoagulant therapy should be initiated.

TL;DR: The available data support a conceptual framework that considers chronic cerebral hypoperfusion a likely, relevant pathogenic mechanism for the neurodegeneration-like progression of the neurocognitive disorders.

TL;DR: The cross-sectional findings suggest that abnormal patterns of hippocampal and amygdala development continue into adolescence in autistic patients, but not after controlling the total brain volume.

TL;DR: Guillain-Barré syndrome can be due to molecular mimicry phenomena, which could explain the autoimmune signs and symptoms that some patients affected by SARS-CoV-2 can experience.

TL;DR: Patients presenting to a large tertiary care academic US hospital with stroke and who tested positive for COVID-19 are retrospectively reviewed, finding Hypercoagulability and the cytokine surge are perhaps the cause of ischemic stroke in these patients.

TL;DR: Findings highlight the need for a brain health action plan to prevent and control AD and to reduce its increasing prevalence and dementia-related costs in China.

TL;DR: This report reports on the initial experience of using the combination of targeted capture sequencing and patients-derived organoid cultures to create a tailored approach of systemic therapies for a patient with GBM, which challenges the conventional treatment paradigm, as well as highlighting the complexities of such an approach and the potential for a more favorable treatment outcome.

TL;DR: In summary, besides ONSD enlargement and papilledema transbulbar sonography demonstrated an alteration of central retinal artery blood flow in IIH patients, especially PSV might serve as valuable surrogate marker for intracranial pressure in IIh.

TL;DR: Two cases demonstrating different and rare forms of severe brain involvement in adult patients with HLH are reported: acute necrotizing encephalopathy, and diffuse hemorrhagic disease due to disseminated intravascular coagulation.

TL;DR: Multifractal detrended fluctuation analysis (MF-DFA) shows promise as a method of quantitative EEG analysis to accurately estimate cognition in Alzheimer's disease.

TL;DR: In this article, three kinds of radiomics features, including Gabor transform, texture and wavelet transform based ones, were used to obtain 300 multimodal features for feature selection and tumor differentiation.