Showing papers in "Journal of Neuroimmunology in 1986"

TL;DR: The results suggest that the pineal gland has important immunomodulatory functions through its cyclic, circadian release of MEL, and MEL administration was able to antagonize the depression of antibody production induced by corticosterone in vivo.

TL;DR: Peripheral blood lymphocytes from active and stable multiple sclerosis patients, patients with other neurologic diseases, and control subjects were tested for sensitization to two myelin antigens not previously examined in multiple sclerosis, using a [3H]thymidine incorporation assay.

TL;DR: None of the 11 anti-alpha derived from denatured AChR bound to the main immunogenic region (MIR) as judged by antibody competition assays, which contrasts with previous results using mAbs against native AChr.

TL;DR: The inflammatory infiltrate within human sural nerve, biopsied from six patients with active chronic inflammatory demyelinating neuropathy (CIDP) was studied for T lymphocyte subsets and Class II antigen (Ia)-expressing cells.

TL;DR: Using monoclonal antibodies different subpopulations of macrophages having varying distribution patterns in the central nervous system can be recognized.

TL;DR: To determine in situ localization of cells bearing major histocompatibility complex (MHC) class I or II antigens in the central nervous system (CNS), immunohistochemical examination was performed on CNS sections of Lewis rats sensitized for experimental allergic encephalomyelitis (EAE).

TL;DR: It is shown that H-2, but not Ia, antigen expression is induced on isolated mouse oligodendrocytes in vitro by crude supernatant from Lectin-activated spleen cells, lectin-free interleukin 2, and cloned gamma-interferon.

TL;DR: It is reported that beta-endorphin and met-enkephalin can enhance the generation of cytotoxic T lymphocytes (CTLs) at suboptimal concentrations of alloantigen in a one-way mixed lymphocyte culture (MLC) to give added proof for the regulatory-loop theory between the neuroendocrine and immune systems.

TL;DR: This is the first demonstration of PLP-induced EAE with significant demyelination in rats and will contribute to the study of autoimmune demYelination.

TL;DR: Serum cortisol concentrations were determined by radioimmunoassay in cancer patients undergoing experimental therapy with recombinant interferon- α 2 in order to understand the actions and side effects of exogenously administered interferons.

TL;DR: C cultured astrocytes do function directly as accessory cells in class I antigen-dependent T cell activation, whereas Ia induction by IFN-gamma is necessary to enable them to present antigen to class II antigen-restricted T cells.

TL;DR: Results support the possible clinical use of mitoxantrone for immunosuppression and highlight the importance of its interaction with the regional draining lymph nodes.

TL;DR: Ten monoclonal anti-human acetylcholine receptor (AChR) monoconal antibodies all exhibited high avidity binding to the human AChR, but none was able to inhibit alpha-bungarotoxin (alpha-Butx) binding toThe receptor.

TL;DR: Evidence that astrocytes can release interleukin-1 and can present an antigen to lymphocytes, and the finding of HLA-DR on them supports their possible involvement in the cellular immune response.

TL;DR: The intrathecal antiviral immune response provides a plausible explanation for immunopathologic destruction of myelin in distemper.

TL;DR: The putative delta-opiate receptor complex has been identified by a new approach which employed an antibody that is directed against a peptide which binds gamma-endorphin and is specified by RNA that is complementary to that of gamma- endorphin mRNA.

TL;DR: Treatment with cyclosporin A, from the time of virus infection, suppressed inflammation and demyelination in the spinal cord of SJL/J or ASW(H-2s) mice persistently infected with Theiler's murine encephalomyelitis virus.

TL;DR: Administration of anti-CD4 MAb to rats can prevent EAE by a mechanism which does not ablate the encephalitogenic CD4+ cells or prevent the development of resistance to EAE but which may inhibit the disease by preventing the function of already activated effector cells.

TL;DR: This study indicates that the Brucella ELISA on CSF is a reliable, rapid, sensitive and specific assay in the diagnosis of central nervous system brucellosis.

TL;DR: The ABH antigens were found mainly in the small and intermediate-size neurons whose central processes project to lamina II of the spinal cord posterior horn.

TL;DR: An investigation of 18 patients with IgM paraproteinemia and neuropathy to test for the presence of antibodies that react with each of these components, finding 7 patients that fell into 3 categories with regard to reactivity with acidic glycolipids.

TL;DR: IgG secretion and Con A suppressor cell function were inversely correlated in MS patients but not in controls, suggesting that in chronic progressive multiple sclerosis a common abnormality underlies both increased response to PWM and decreased induction of suppression by Con A.

TL;DR: It is demonstrated that BP sensitized Ig deficient rats which do not develop EAE, nevertheless generate effector cells capable of transferring disease, and thus specific T-cell function is not inhibited by the anti-Ig treatment.

TL;DR: Four samples of thymoma obtained from patients affected by myasthenia gravis have been immunohistologically analysed on cryostat sections using a panel of antisera and monoclonal antibodies specific for antigens which define different stages of intrathymic lymphocyte differentiation and antigen specific for different types of thcyic epithelial cells (cortical, medullary).

TL;DR: A rapid and sensitive radioimmunological method is described, using decamethonium (DC), which revealed antibodies which blocked alpha-bungarotoxin binding to human acetylcholine receptor (AChR) in 98% of myasthenia gravis patients' sera tested, but no sera from asymptomatic or ocular MG patients had the dual capacities of blocking alpha-Bgt binding.

TL;DR: Serum IgM and antimyelin antibodies decreased during plasma exchange and no increase beyond initial levels was noted after cessation of treatment, and plasma exchange alone, without chemotherapy, proved beneficial in 2 patients.

TL;DR: By immunotransfer and absorption experiments, it was found that the antiserum bound to proteolipid protein and a closely related protein, DM-20; it did not bind to basic protein or other myelin proteins.

TL;DR: A significant reduction in the incidence of experimental allergic encephalomyelitis in SJL/J mice was observed when mice were infected with lactic dehydrogenase virus (LDV) 14 days before, on day 0, or 3 days after immunization with spinal cord homogenate.

TL;DR: A detailed immunochemical examination of monoclonal and polyclonal antibody responses to myelin basic protein and its peptides has revealed the existence of as many as 27 antigenic determinants, many of them conformational.

TL;DR: The data suggest that neonatal MG is due to maternal anti-AChR abs and that affected infants do not produce specific antibodies.