Showing papers in "Liver Transplantation in 2015"

TL;DR: The success rate of downstaging HCC to within Milan criteria exceeds 40%; however, posttransplant HCC recurrence rates are high at 16%.

TL;DR: Curbing weight gain in the early months after liver transplant may impact MS and subsequent CVD in the long term, and more data are needed to identify nonconventional risk factors and biomarkers like serum TN.

TL;DR: A model for the quantitative assessment of EAD severity has been developed and validated for the first time and provides a more accurate graft function assessment than current categorical classifications and may help clinicians to make early enough decisions on retransplantation benefits.

TL;DR: It is suggested that patients with HRS1 should receive a timely liver transplant to improve their outcome and the duration of pretransplant dialysis with a 6% increased risk of nonreversal with each additional day of dialysis.

TL;DR: Empirical findings provide support for the idea that NASH is a prothrombotic state, and they should lead to more research in treatment and prevention in this population of patients.

TL;DR: Evaluated clinical predictor variables for early and late cardiac morbidity and mortality and the predictive values of noninvasive cardiac tests for perioperative cardiac events in a high‐risk liver transplant population found that Dobutamine stress echocardiography and single‐photon emission computed tomography had respective sensitivities.

TL;DR: The sequential procedure, in which ATTR livers are reused in patients with liver disease, reveals that neuropathy in the recipient may appear as soon as 6 years after OLT, and ATTR deposits may appear even earlier.

TL;DR: Time‐zero biopsies predict adverse clinical outcomes after liver transplantation, and severe IRI upon biopsy signals the likely need for early retransplantation.

TL;DR: The findings suggest that biomarkers are useful for predicting the risk of HCC recurrence after transplantation and using both biomarkers and the Milan criteria may be better than using the Milan criterion alone in optimizing the decision of liver transplantation eligibility.

TL;DR: Treatment with a 12‐week regimen of sofosbuvir and simeprevir was well tolerated and resulted in a high SVR12 rate for LT recipients with recurrent HCV genotype 1 infection, a retrospective analysis of a single‐center treatment protocol.

TL;DR: In this paper, the authors used the United Network for Organ Sharing (UNOS) database to inform a 20-year discrete event simulation estimating liver transplant volume from 2010 to 2030, in part because of worsening donor organ quality.

TL;DR: In this paper, the authors investigated the impact of intraoperative tissue plasminogen activator (tPA) on outcomes following DCD LT, and concluded that tPA injection into the hepatic artery during DCD transplant reduces ITBSs and improves graft and patient survival without increasing the risk for bleeding.

TL;DR: A small and nonsignificant increase in median fibrinogen transfusions was found for the with group, and it was not associated with a decrease in blood transfusions or in the number of patients exposed to blood products.

TL;DR: In experienced living donor centers, laparoscopic liver donation appears to be feasible for all pediatric recipients and some adult recipients and for the recipients of laparoscopically procured grafts, which do not appear significantly different from outcomes with hybrid/open techniques.

TL;DR: Pregnancy following LT has a favorable outcome in the majority, but severe maternal risks remain, and pregnancy must be considered high risk with regular monitoring by transplant clinicians and specialist obstetricians.

TL;DR: Both donors and recipients had rapid yet incomplete restoration of tissue mass in the first 3 months, and this confirmed previous reports, and donor liver volume is a critical predictor of the rate of regeneration and donor remnant fraction affects postresection function.

TL;DR: Overweight and obese LT recipients do not have increased risk of death or graft loss regardless of MELD, and underweight patients are at increased risk for poor outcomes post‐LT, specifically underweight recipients with low MELD have increasedrisk for death and graft loss.

TL;DR: Inadequate treatment knowledge and improper regimen use may be significant determinants of unintentional nonadherence among LT recipients and are associated with adverse clinical outcomes.

TL;DR: In an endemic area, post‐LT CRKP infection is common, occurring in 6.6% of recipients, and is strongly associated with post-LT mortality, and improved strategies for screening and prevention are urgently needed.

TL;DR: IA causes life‐threatening infections in liver transplant recipients and the use of voriconazole was significantly associated with a higher probability of survival, and predictors associated with poor outcomes may help clinicians to optimize the management of this infection.

TL;DR: Although young ALF patients in the US Acute Liver Failure Study Group with grade III or IV hepatic encephalopathy may benefit, TH did not consistently affect 21‐day survival and complications in ALf patients at high risk for cerebral edema.

TL;DR: It is time to recognize that the efforts to regulate transplantation and provide voluntary citizen‐based deceased organ donation have been successful and that China should use this system to provide organs for all transplants in every province and hospital in China.

TL;DR: LT‐listed patients with end‐stage liver disease and infection have a 42% risk of delisting/death within a 6‐month period following an admission and the number of organ failures was highly predictive of the risk for delisted/death.

TL;DR: Compared to SCS, end‐ischemic oxygenated MP of DCD livers provides better preservation of biliary epithelial function and morphology, independent of the temperature at which MP is performed.

TL;DR: A survey of LT centers in the United States with an aim to examine practice patterns on the use of LT for severe AH found that LT for AH patients still faces resistance, possibly because of organ shortage, sociocultural and ethical issues, and fear of recidivism after LT.

TL;DR: A tPA injection into the hepatic artery during DCD LT reduces ITBSs and improves graft and patient survival without increasing the risk for bleeding.

TL;DR: A retrospective analysis of data collected from 2001 to 2011 in a single high‐volume North American pediatric transplant center demonstrates a lower incidence of biliary complications with RY biliary reconstruction, and patients with biliary complication have decreased graft survival.

TL;DR: To treat borderline hepatocellular carcinoma, LT with type 2 DCD donors is possible as long as strict donor selection is observed.

TL;DR: Treatment of patients with type 2 HRS with terlipressin and albumin does not appear to have beneficial effects either in pretransplantation or in posttransplantation outcomes.

TL;DR: The performance of current criteria for SU transplantation could be improved if paracetamol‐induced ALF and non–paracetaml‐ induced ALF were split and 2 other items were included in this model: the bilirubin level and creatinine clearance.