Showing papers in "Phytochemistry Letters in 2010"

TL;DR: A single chemical entity antineoplastic agents from higher plants that are currently in clinical trials as cancer chemotherapy drug candidates are described, representative of a wide structural diversity.

TL;DR: The qualitative and quantitative analysis of flavonoids from Opuntia ficus-indica flowers methanol extract from the Mediterranean area is described in this paper, where seven compounds have been identified as kaempferol, quercetin, and isorhamnetin glycosylated derivatives.

TL;DR: Two new presilphiperfolane sesquiterpenes were isolated from the ethyl acetate extract of Xylaria sp.

TL;DR: The closely related plant families of Caryophyllaceae and Illecebraceae are reviewed for their saponins and an overview with special attention on the contained sapogenins and their linkage of sugar moieties are provided.

TL;DR: Two new naphthalene acylglucosides, rumexneposides A and B, together with 12 known compounds (3-14), were isolated from the roots of Rumex nepalensis and evaluated against Mycobacterium tuberculosis, para-aminobenzoic acid (pAba) pathway, and a panel of human cancer cell lines.

TL;DR: The alkaloids ungeremine, pseudolycorine and haemanthamine showed good activity in in vitro assays against Trypanosoma brucei rhodesiense, T. cruzi and Plasmodium falciparum with IC 50 values in the range of 3.66 μM or lower.

TL;DR: Three new metabolites, 5-hydroxy-3,7-dimethoxyflavone-4′-O-β-glucopyranoside (1), 2β,19-epoxy-3β,14β-dihydroxy-19-methoxy-5α-card-20(22)-enolide (4), along with two known compounds, uzarigenine (2) and β-anhydroepidigitoxigenin (3), were isolated from Calotropis procera (Asc

TL;DR: Michalik, A., Hollinshead, J., Jones, L., Fleet, G. W., Horne, G., Wilson, F. J., Yu, C-Y, Hu, X-G., van Well, R., HorNE, G, Wilson, W., Nash, R. J. as discussed by the authors proposed a new indolizidine alkaloid from Stevia Rebaudiana.

TL;DR: A new symmetrical pyrano-3-deoxyanthocyanidin, containing apigeninidin as a base unit, displays structural features responsible for higher stability as compared to corresponding anthocyanins.

TL;DR: The isolation of three novel diterpenoids from the root bark of P. integrifolia are reported, which belong to a limited number of families and their isolation is also interesting from chemotaxonomic point of view.

TL;DR: In this article, three new endiandric acid derivatives, beilschmiedic acids D, E, and B, were isolated from the stem bark of Beilschmedia anacardioides together with the known compounds bisabolene and tricosanoic acid.

TL;DR: Findings illustrate that members of the Nepeta genus possess a diverse range of high value secondary metabolites, and also highlight their potential to be developed as renewable feedstocks for the production of repellents for use economically important crop pests, as well as for theproduction of sex pheromones and natural enemy attractants.

TL;DR: Cyclo -( l -Pro- l -Met) was isolated from the fermentation broth of a marine-derived actinomycete Nocardiopsis sp.

TL;DR: Phytochemical investigation of the leaf surface exudate of Dodonaea angustifolia yielded two new neo-clerodane diterpenes, neo -clerodan-3,13-dien-16,15:18,19-diolide (mkapwanin) and 15-methoxy- neo - clergyodan- 3, 13-dierpenes (15-Methoxymkap Swanin).

TL;DR: A bioactivity-guided fractionation of the chloroform extract of the seeds of Picralima nitida using glucose uptake in fully differentiated 3T3-L1 adipocytes afforded six indole alkaloids and a mixture of four 5-hydroxy tryptamine amides accounted for the increase in glucose uptake observed in the chlorOform extract.

TL;DR: In this paper, two new acylated flavonol pentaglycosides were isolated from the butanolic extract of Baphia nitida leaves by Sephadex LH-20 and preparative HPLC.

TL;DR: The new diterpenes showed no activity against Gram-negative bacteria and Candida albicans (yeast strain) and among Gram-positive bacteria, the lower MIC value was 62.50 μg/ml for the abietane derivative against Staphylococcus aureus ATCC 6538.

TL;DR: A simple method for transforming parvifloron D (2)(Ru¨edi and Eugster,1978; Van Zyl et al., 2008) into the 2-oxoderivative of microstegiol is reported.

TL;DR: Two new quaternary alkaloids were isolated along with the known alkaloid strictosamide from the leaves of Psychotria prunifolia (Kunth) Steyerm and their structures were elucidated using spectroscopic methods.

TL;DR: Two new eremophilane sesquiterpenes, compounds 1 and 2, were isolated from the endophytic fungus Microdiplodia sp.

TL;DR: In this paper, a new dimeric p-coumaroyl glucose and two monomeric cis p-Coumaroysl and feruloyl derivatives have been isolated along with three known related compounds.

TL;DR: In this paper, an easy, fast and non-destructive method by Nuclear Magnetic Resonance of proton (1H NMR) for quantification of DMT in ayahuasca samples was developed and validated.

TL;DR: In this article, a new xanthone, 3,4-dihydro-8,10,12-trihydroxy-2,2-dimethylpyrano[2,3- b ]xanthen-11(2 H )-one or butyraxanthone E (1), along with the known compounds 30- epi -cambogin (2), 1,7-Dihydroxyxanthone (3 ) and 1,5-diboxanthone(4 ) were isolated from the roots of Pent

TL;DR: In this paper, Gutathione S-transferase (GST) inhibition-directed fractionations on the ethanolic extract of Artocarpus nobilis of Sri Lanka origin yielded four known triterpenoids, cyclolaudenyl acetate (1), lupeolacetate (2), β-amyrine acetate, and zizphursolic acid (4), along with five known flavonoids, artonins E (5), artobiloxanthone (6), artoindonesianin U (7),

TL;DR: The naphthoquinones, lapachol, plumbagin, 2-isopropenyl-9-methoxy-1,8-di-oxa-dicyclopenta, and 5,7-dihydroxy-8-methyl-2-methyl-1-4-naphthoequinone (6) were isolated isolated from roots of Plumbago zeylanica as discussed by the authors.

TL;DR: An investigation into the keto-enol relationships in a number of hop acids provides evidence to show that they inhibit cell growth, induce caspase dependent apoptosis and inhibit adhesion of some cancer cells to bone tissue.

TL;DR: Three new neo -clerodane diterpenoids, named scutelinquanines A–C ( 1 – 3 ), were isolated from the whole plant of Scutellaria barbata and showed significant cytotoxic activities against three human cancer lines.

TL;DR: In this article, a new Lycopodium alkaloid, 8S-O-acetylepiclavolonine, was isolated from the Icelandic club moss Diphasiastrum alpinum and its structure and stereochemistry was determined using a combination of NMR spectroscopy and mass spectrometry.

TL;DR: Two new benzochromenes were isolated from the root extract of Bourreria pulchra and especially 1 was found to possess significant activity against Leishmania mexicana and Trypanosoma cruzi parasites.

TL;DR: The new phenolic metabolites 3-(2-butoxy-3-caffeoyl-1-hydroxycyclobutyl)-3-hydroxpropanoic acid, named as dorycnic acid (1), and 4-O-(4′-carboxymethyl-2′,4′,6′-trihydroxcyclohexyl)-vanillic acid (2), together with scopolin (3), kaempferol 3-rutinoside (4), scopoletin (5), and methyl caffeate