Showing papers in "Seminars in Arthritis and Rheumatism in 1996"

TL;DR: Experimental evidence is emerging that catabolic cytokines are mediators of joint damage in OA, although their usefulness as markers of disease activity is limited because of the need to monitor a wide range of ligands and their inhibitors simultaneously.

TL;DR: A vast array of adhesive interactions occurs between immunocompetent cells, endothelium, extracellular matrix, and target tissues during the evolution of an autoimmune disease.

TL;DR: Patients with ILD and anti-synthetase antibodies in whom underlying myositis was not clinically evident and who have a cytoplasmic pattern by antinuclear antibody testing on HEp-2 cells should be considered for testing, because early recognition and treatment of such patients affects their clinical course.

TL;DR: Disease activity and treatment are responsible for the extensive defects of the immune defense system in lupus patients that increase their susceptibility to an extensive range of infections.

TL;DR: The most important achievement in recent years is the mapping of the FMF susceptibility gene to chromosome 16p, a finding that raises hopes for prompt cloning of the gene and elucidation of the mechanisms involved in FMF expression.

TL;DR: Because psychological and familial factors were not different in children with and without FMS, the high familial occurrence of this syndrome may be attributable to genetic factors.

TL;DR: Rheumatoid arthritis progresses as an autoimmune disease and evolves into a chronic inflammatory joint disease complicated by recurrent episodes of systemic acute-phase reactions, which sometimes result in amyloidosis.

TL;DR: The effect of geographic origin suggests that environmental or ethnic differences also may influence the prevalence of chronic arthritis in children, and differences in the percentages of patients with pauciarticular and polyarticular JRA may reflect racial differences inThe prevalence of these conditions.

TL;DR: The current status of the clinicopathologic factors related to non-Hodgkin's lymphoma (NHL) development in patients with Sjögren's syndrome (SS) are summarized and monoclonality is considered to be a precursor for NHL development in SS.

TL;DR: The contributory role of tuberculous infection in the morbidity and mortality of patients with SLE must be emphasized, especially in areas endemic for TB.

TL;DR: Systemic lupus erythematosus (SLE) may have protean manifestations, including necrotizing lymphadenitis, which is pathologically similar to Kikuchi-Fujumoto disease (KFD) and the pathologic and clinical literature support a close link between SLE and KFD.

TL;DR: A clinical interpretation can enhance the value of computer-generated bone mass measurement reports and improve decision making on the basis of the patient's circumstances and the precision of measurement.

TL;DR: MRI is a useful method of determining the extent of disease in tophaceous gout and may provide information regarding the patterns of deposition and spread of monosodium urate crystals.

TL;DR: Vasculitis may predate the diagnosis of the lymph oproliferative disease, and patients with vasculitis should be screened and monitored for lymphoproliferatives diseases.

TL;DR: The combination of cytokine inhibitors is a potential therapeutic approach in the treatment of immunoinflammatory diseases because the nonspecific effects of immunosuppressive drugs are improved by using inhibitors with more specific actions on the functions of proinflammatory cytokines.

TL;DR: This review examines the validity of the hypothesis that NSAIDs exhibiting selectivity for COX2 demonstrate an improved safety and efficacy profile when compared withNSAIDs exhibitingSelectivity forCOX1, and finds some support for the hypothesis, but there exists no support for improved efficacy.

TL;DR: Results of all studies were consistent in showing beneficial and often dramatic improvements in QOL after elective THR, and improvements were most likely to occur within the first 3 to 6 months after THR.

TL;DR: Promising results are being obtained with selective antagonism of TNF and IL-1 in RA, and combinations of anticytokine strategies with traditional antirheumatic drugs have been already envisaged.

TL;DR: End-stage renal failure in patients with silent lupus nephritis is rare regardless of the histopathological renal lesions, and patients survival depends on nonrenal causes.

TL;DR: Although symptomatic muscular involvement in RA is low, it is found that nearly two thirds of cases were caused by potentially treatable conditions, mainly myositis or toxic myopathies.

TL;DR: The ability of US to provide information with management implications is confirmed, and US-guided corticosteroid injection is beneficial, especially after failure of nonguided injection.

TL;DR: Sensitivity analysis showed, even when efficacy and safety were optimized, costs for the BIO still substantially exceeded those of MTX and IMG and will be an important consideration in the development of novel BIOs for RA.

TL;DR: Experiments show that arthritis patients manifest T-cell responses to the hsp-65-kD molecule, as do rats with adjuvant arthritis, and studies on sensitivity and specificity of these antibodies do not exist; therefore, their significance should be interpreted cautiously.

TL;DR: Radiography, along with nuclear medicine scans, arthrography, and computed tomography scans, are limited in their use because they are unable to detect early cartilage abnormalities and magnetic resonance imaging has the advantages of multiplanar imaging, soft tissue contrast, and noninvasiveness.

TL;DR: It is indicated that aCL are associated with DR4, DR7, and DRw53, at least when they are found in patients with systemic lupus erythematosus, and HLA-DR4 seems to be more important in Anglo-Saxons, whereas DR7 emerges in populations of Latin origin.

TL;DR: The incidence of atypical mycobacterial skeletal infection in HIV-infected individuals was significantly higher than in the general county hospital district patient population, whereas the frequency of Myobacterium tuberculosis skeletal infection did not differ significantly between the two populations.

TL;DR: It is suggested that HYC-141 may possess certain advantages over the individual component molecules in the local treatment of arthropathies because of its ability to protect tissues from attack by reactive oxygen species.

TL;DR: It is believed cyclosporine A is the drug of choice in severe CHP and should be considered in all such patients and rapid remission was achieved in this patient and all five previously published cases.

TL;DR: Seven elderly women with insufficiency fractures of the pubic ramus in the elderly are described, and bone scintigraphy and computed tomography were necessary to confirm the diagnosis and detect additional fractures.

TL;DR: The presence of autoantibodies to nuclear pore complexes and anti-LaAutoantibody specificities, the rare occurrence of anti-Jo-1 autoant ibodies, the response to conventional therapies, and a high survival rate may distinguish idiopathic inflammatory myopathies in French Canadians from that of other reported series.