Showing papers in "Surgical Oncology Clinics of North America in 2008"

TL;DR: Perfusion cannot be recommended as an adjunct to wide local excision in patients who have primary melanoma, however, may be of value because it lengthens the limb recurrence-free interval and decreases the number of lesions per recurrence significantly.

TL;DR: Methods for detecting and identifying the recurrent laryngeal nerve are explored and the evolution of functional RLN monitoring is examined, its potential advantages and disadvantages, statistical validity, and its role in the current medicolegal climate are examined.

TL;DR: The indications and the results for liver resection for hepatocellular cancer (HCC) depend on the stage of the tumor at diagnosis, the functional reserve of the liver, and the use of suitably adapted surgical techniques.

TL;DR: The thyroid surgeon must have a thorough understanding of laryngeal neuroanatomy and be able to recognize symptoms of vocal fold paresis and paralysis to avoid the development of complications and improve patient quality of life.

TL;DR: The pharmacologic benefits of HAI therapy are reviewed and the contemporary trials performed and underway, including those for liver metastases from colorectal cancer, are reviewed.

TL;DR: Identifying new RET pathways has provided molecular targets for therapies that currently are being tested in clinical trials for locally advanced, metastatic, and recurrent medullary thyroid cancer.

TL;DR: The literature relating to the assessment of disease, surgical management, and adjuvant therapy for invasive thyroid cancer of the aerodigestive tract and RLN is discussed and suggestions based on the authors' experience are made.

TL;DR: The rapid increase in the rate of papillary thyroid cancer is likely caused by improved surveillance, and compelling arguments for thyroid lobectomy and total thyroidectomy for low-risk thyroid cancer remain.

TL;DR: Although prospective, randomized clinical trials never have been conducted, retrospective and comparative studies strongly indicate that hepatic resection is the only available treatment that allows long-term survival in colorectal carcinoma that has metastasized to the liver.

TL;DR: The rationale, historical background, and current state of investigations for patients treated in intra-arterial infusion of chemotherapy agents for cancer of the head and neck are provided.

TL;DR: Technology innovations are facilitating new approaches to surgery of the thyroid gland, including minimally invasive approaches that have the added advantage of allowing the surgeon to avoid drains, thus enabling outpatient surgery and surgical robotics, with the promise of further enhanced visualization and surgical dexterity better than that possible with traditional endoscopic approaches.

TL;DR: Further efforts are needed to elaborate more precise algorithms for selecting candidates for induction therapy versus primary surgery for cancer of the esophagus and gastroesophageal junction.

TL;DR: The percutaneous approach to IHP, the treatment of additional tumor types (eg, unresectable hepatocellular carcinoma, gastrointestinal sarcoma, occult primaries), the use of other agents within the IHP circuit, and gene therapy all deserve additional attention.

TL;DR: Regional chemotherapy was developed in the 1950s and continues to play an integral part in the development of newer therapies for advanced solid malignancies.

TL;DR: Continued molecular analysis of thyroid cancers promises to increase the understanding of its biologic behavior and is expected to have further impact on its clinical management.

TL;DR: Studies performed in larger and more homogeneous series of patients and adequate statistical analysis are warranted before any of the candidate biomarkers can be implemented in the routine clinical setting for the identification of patients at higher risk and thus for the selection of candidates for adjuvant or more aggressive therapies.

TL;DR: Most thyroid neoplasms arise from follicular cells and are well differentiated, and Anaplastic and poorly differentiated carcinomas are rare and have a high mortality.

TL;DR: Development of new treatment strategies in extremity perfusion, better perfusion or infusion equipment, and modifying the technique and the use of molecular imaging technology might further improve limb salvage rates and decrease local failures in the future and provide more insight into the tumor biology of sarcoma.

TL;DR: Sentinel lymph node biopsy allows conservation of the axillary lymph nodes in most patients who have breast cancer and allows identification of occult nodal disease after step sectioning and more detailed staging.

TL;DR: This technique provides a simple and versatile means of complete extracapsular thyroidectomy for lesions of the thyroid gland and minimizes postoperative complications.

TL;DR: Advances were made through the use of randomized clinical trials, standardized restorative surgery, and more accurate preoperative staging by MRI.

TL;DR: The targeted agents used for solid malignancies and the evidence for current tumor-specific therapies are reviewed.

TL;DR: The problems of regional chemotherapy for the treatment of carcinoma of the lung will be dealt with.

TL;DR: Evidence from randomized, controlled trials of adjuvant surgical therapy, sentinel node biopsy, and surveillance of regional lymph node basins by ultrasound is discussed, showing Interferon has a consistent effect on relapse-free survival, although it does not have a significant benefit for overall survival.

TL;DR: A number of proposals for a new, meaningful staging system for advanced colorectal cancer are discussed, which categorizes all disease spread beyond the lymph node basin of the primary tumor as unstratified stage 4.

TL;DR: For the office-based practitioner, thyroid nodule presentation patterns are changing with discoveries of more thyroid "incidentalomas" and with new risk assessment challenges associated with small (<1 cm) nodules.

TL;DR: Recent advances in gastric cancer research that have improved treatment and outcomes of gastric malignancy, or have the potential to do so, are discussed.

TL;DR: The combination of genomics and proteomics has provided a unique opportunity to diagnose, classify, and detect malignant disease, to better understand and define the behavior of specific tumors, and to provide direct and targeted therapy.

TL;DR: Clinical outcomes, recent technologic advances in treatment planning and radiation delivery, and potential morbidity associated with treatment are reviewed.

TL;DR: The technique criteria and the response to IPP from seven literature studies of isolated pelvic perfusion with colorectal cancer are reviewed to lead to a more standardized and improved procedure.