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Showing papers in "The Breast in 2001"


Journal ArticleDOI
TL;DR: Thermoplastic moulding shows promise and should be further investigated as it gives not only a volume assessment but a three-dimensional impression of the breast shape, which may be valuable in assessing cosmesis following breast-conserving-surgery.

122 citations


Journal ArticleDOI
TL;DR: The period 1990-1997 saw the implementation of a nationwide breast cancer screening programme in the Netherlands, which provided biennial mammography for all women aged 50-69 years (50-75 years at present).

117 citations


Journal ArticleDOI
TL;DR: Preclinical studies indicate that Myocet accumulation in tumour tissue is more persistent and pervasive than that of conventional doxorubicin and is targeted away from the heart, leading to reduced cardiotoxicity without compromising antitumour efficacy.

103 citations


Journal ArticleDOI
TL;DR: The results show that if less than 20% of the breast was removed, all assessors felt that the cosmetic result was at least fair, then a breast reconstruction procedure should be considered, if cosmetic outcome is to be enhanced.

99 citations


Journal ArticleDOI
TL;DR: Overall, double reading increases the cancer detection rate by 3-11 per 10,000 women screened and has a double impact on recall rates depending on the recall policy used, and double reading can improve accuracy as compared with single reading.

97 citations


Journal ArticleDOI
TL;DR: It is hypothesized that dietary iodine deficiency is associated with the development of mammary pathology and cancer and a review of the literature on this correlation and of the author's own work on the antioxidant function of iodide in iodide-concentrating extrathyroidal cells is reported.

80 citations


Journal ArticleDOI
TL;DR: The contrast suggests that patient perception of the severity of underlying illness may determine reported QL scores, and there is strong prognostic significance after disease relapse.

62 citations


Journal ArticleDOI
TL;DR: Arm swelling occurred at some time in 39% of women, was present in 20% 1 year, and in 29% 4 years, after diagnosis, but was not related to age, number of nodes excised or self-reports of radiation or type of surgery.

58 citations


Journal ArticleDOI
TL;DR: Recall after mammography is associated with transiently increased levels of anxiety and depression in women without cancer and for those with cancer, the psychological distress continues.

47 citations


Journal ArticleDOI
Stephen W. Duffy1
TL;DR: This paper reviews and rebutts the recent criticisms of breast screening trials published earlier this year in the Lancet.

47 citations



Journal ArticleDOI
TL;DR: The results should stimulate international collaboration on a larger study to determine whether chemotherapy is useful for premenopausal patients classified as having an endocrine-responsive breast cancer who receive adequate adjuvant endocrine therapy, and whether ovarian function suppression is an essential component of an adjUvant treatment program for these patients.

Journal ArticleDOI
TL;DR: The type and frequency of breast problems in young women less than 20 years of age are discussed in this paper, with most presenting lesions being benign.

Journal ArticleDOI
TL;DR: A pilot study to develop a suitable cognitive battery of tests for the evaluation of cognitive function in women receiving hormonal therapy for the treatment or prevention of breast cancer is introduced.

Journal ArticleDOI
TL;DR: The anatomy of the intercostobrachial nerve is found to be variable, but six main variants are illustrated, which are able to preserve the nerve in 40 out of 50 cases.

Journal ArticleDOI
TL;DR: There seems to be a complex interaction between malignant cells and adjacent cells in which factors such as IL-6 and its soluble receptor, TNF-alpha and prostaglandin E2 play an important role in stimulating aromatase activity.

Journal ArticleDOI
TL;DR: In this article, the authors evaluated HER-2/neu and p53 expression, conventional clinical and pathologic prognostic factors, in a retrospective series of 283 node-positive breast cancer patients.

Journal ArticleDOI
TL;DR: Although locoregional relapse was increased in the presence of ENS, axillary relapses were uncommon and do not warrant axillary radiation.

Journal ArticleDOI
TL;DR: In WGE, large mammographic lesions carry a significant risk for radiologically incomplete excision, while pathologically large and multifocal tumors may be histologically incompletely excised, especially if the excision does not extend down to the pectoral fascia.

Journal ArticleDOI
TL;DR: Intraoperative electron-beam radiation therapy (IOERT) as a sole modality of radiation in selected patients with early-stage breast cancer is evaluated at the European Institute of Oncology.

Journal ArticleDOI
TL;DR: It is confirmed that bone-mass density is a strong predictor for breast cancer in postmenopausal women and the mechanisms underlying this relation may be explained by cumulative exposure to oestrogen.

Journal ArticleDOI
TL;DR: Although myofibroblastomas and solitary fibrous tumours of the breast share many morphologic features, there are enough differences in their cytologic composition and, most importantly, in their immunohistochemical profile to consider them as distinct entities.

Journal ArticleDOI
TL;DR: There is little difference between the precision of ultrasound and mammography in measuring tumour size, and the wide 95% confidence intervals for any method of pre-operative tumour measurement should be considered when planning patient management.

Journal ArticleDOI
TL;DR: Although not significant, subcutaneous tissue was more echogenic on the oedematous side, with significant hyperechogenicity at the fascial sub cutaneous layer, which indicates that fibrotic tissue develops distally in the forearm.

Journal ArticleDOI
TL;DR: A comparison between clinical, ultrasound scan (USS), mammographic and magnetic resonance imaging (MRI) of 22 patients with invasive lobular breast carcinomas was made by as mentioned in this paper. But the results showed that MRI was more accurate at assessing tumour size than USS and clinical examination.

Journal ArticleDOI
TL;DR: MRM was performed in 223 patients with 234 histopathologically proven malignant breast lesions which were analyzed prospectively by routine analysis prior to surgery and re-analyzed by specialists, retrospectively, with respect to contrast enhancement, size and shape of lesions, reading errors, and technical problems.

Journal ArticleDOI
TL;DR: In this paper, a pragmatic study aimed to examine the ability of commonly reported tumour pathological features to predict axillary metastases and found that vascular invasion and tumour size were independent predictors of positive nodes but tumour grade was not.

Journal ArticleDOI
TL;DR: Repeated fine needle aspiration cytology with close follow-up have proven to be a reliable method of establishing the diagnosis of fat necrosis of the breast, thereby reducing the necessity for open biopsy.

Journal ArticleDOI
TL;DR: The changes in presentation since the original description of the condition are reviewed, and it is highlighted that although this series reflects difficult cases, fat necrosis remains a condition which can be difficult to diagnose.

Journal ArticleDOI
TL;DR: Histologically, these tumours are invasive ductal carcinomas with OMGCs next to the neoplastic glands and within their lumen; signs of recent and past haemorrhage are ubiquitously present in the highly vascularized stroma.