Showing papers in "Translational Neuroscience in 2019"

Nox2-dependent neuroinflammation in an EAE model of multiple sclerosis

Abstract: Background Multiple sclerosis (MS) is an inflammatory disease of the CNS, characterized by demyelination, focal inflammatory infiltrates and axonal damage. Oxidative stress has been linked to MS pathology. Previous studies have suggested the involvement of NADPH oxidase 2 (Nox2), an enzyme that catalyzes the reduction of oxygen to produce reactive oxygen species, in the MS pathogenesis. The mechanisms of Nox2 activation on MS are unknown. The purpose of this study was to investigate the effect of Nox2 deletion on experimental autoimmune encephalomyelitis (EAE) onset and severity, on astrocyte activation as well as on pro-inflammatory and anti-inflammatory cytokine induction in striatum and motor cortex. Methodology Subcutaneous injection of MOG35-55 emulsified with complete Freund's adjuvant was used to evaluate the effect of Nox2 depletion on EAE-induced encephalopathy. Striatum and motor cortices were isolated and evaluated by immunoblotting and RT-PCR. Results Nox2 deletion resulted in clinical improvement of the disease and prevented astrocyte activation following EAE induction. Nox2 deletion prevented EAE-induced induction of pro-inflammatory cytokines and stimulated the expression of the anti-inflammatory cytokines IL-4 and IL-10. Conclusions Our data suggest that Nox2 is involved on the EAE pathogenesis. IL-4 and IL-10 are likely to be involved on the protective mechanism observed following Nox2 deletion.

Processing of Action and Sound Verbs in Context: An FMRI Study.

Abstract: Recent theories propose a flexible recruitment of sensory and motor brain regions during conceptual processing depending on context and task. The present functional magnetic resonance imaging study investigated the influence of context and task on conceptual processing of action and sound verbs. Participants first performed an explicit semantic context decision task, in which action and sound verbs were presented together with a context noun. The same verbs were repeatedly presented in a subsequent implicit lexical decision task together with new action and sound verbs. Thereafter, motor and acoustic localizer tasks were administered to identify brain regions involved in perception and action. During the explicit task, we found differential activations to action and sound verbs near corresponding sensorimotor brain regions. During the implicit lexical decision task, differences between action and sound verbs were absent. However, feature-specific repetition effects were observed near corresponding sensorimotor brain regions. The present results suggest flexible conceptual representations depending on context and task. Feature-specific effects were observed only near, but not within corresponding sensorimotor brain regions, as defined by the localizer tasks. Our results therefore only provide limited evidence in favor of grounded cognition theories assuming a close link between the conceptual and the sensorimotor systems.

Autobiographical Memory Increases Pupil Dilation.

Abstract: Background Pupil activity has been widely considered as a “summed index” of physiological activities during cognitive processing. Methodology We investigated pupil dilation during retrieval of autobiographical memory and compared pupil diameter with a control condition in which participants had to count aloud. We also measured pupil diameters retrieval of free (i.e., first memory that comes to mind), positive, and negative memories (memories associated, respectively, with the words “happy” and “sad”). Results Analyses demonstrated larger pupil diameters during the free, positive, and negative autobiographical memory retrieval than during the control task. Analyses also demonstrated no significant differences in pupil diameters across the three autobiographical memory conditions. Conclusion These outcomes demonstrate that, compared with counting, autobiographical retrieval results in a larger pupil size. However, the emotional valence of memories yields non-significant effect on pupil diameters. Our findings demonstrate how autobiographical memory retrieval yields pupil dilation.

Change of Cognitive Functions after Stroke with Rehabilitation Systems.

Abstract: The objective of this study is to assess and compare the effect of applying a computerised cognitive training programme and virtual environment rehabilitation system on cognitive functions in patients after a stroke. Methods. A controlled trial included 121 persons referred to second stage rehabilitation. The subjects were differentiated into three impact groups by a single blinded trial. Results. The trial revealed that cognitive functions improved in all patient groups (p<0.001). A paired comparison analysis of all groups demonstrated a tendency for cognitive functions, evaluated by the MoCA–LT test, to be more strongly improved in patients who practised a computerised cognitive training programme during their OT sessions than those who did not (p=0.054). Conclusions. The final outcome of the trial was that cognitive functions significantly improved in patients who practised computerised cognitive training programmes or virtual environment rehabilitation systems, compared to those participants who only had occupational therapy sessions.

Study on the progress of neural mechanism of positive emotions

Abstract: Positive emotions refer to emotions accompanied by pleasant feelings, such as happiness, interest, satisfaction, pride, and love, which are generated by individuals in response to internal and external stimuli and events. Positive emotions are conscious processes that involve a variety of components, such as a pleasant experience, facial/body expressions, evaluations, and especially behavioural plans and activation states. People's cognitive process is often accompanied by emotions, and the influence of positive emotions on cognitive activities has gradually become the focus of research in recent years. This study constructs a regulation model and an assessment model of positive emotions, and analyses the neural mechanisms of the effects of dopamine substances on human positive emotions.

Heart Rate Variability and Vagus Nerve Stimulation in Epilepsy Patients.

Abstract: Background Vagus nerve stimulation (VNS) exerts a cortical modulating effect through its diffuse projections, especially involving cerebral structures related to autonomic regulation. The influence of VNS on cardiovascular autonomic function in drug-resistant epilepsy patients is still debated. We aimed to evaluate the impact of VNS on cardiovascular autonomic function in drug-resistant epilepsy patients, after three months of neurostimulation, using the heart rate variability (HRV) analysis. Methodology Multiple Trigonometric Regressive Spectral analysis enables a precise assessment of the autonomic control on the heart rate. We evaluated time and frequency-domain HRV parameters in resting condition and during sympathetic and parasympathetic activation tests in five epilepsy patients who underwent VNS procedure. Results We found appropriate cardiac autonomic responses to sympathetic and parasympathetic activation tests, described by RMSSD, pNN50, HF and LF/HF dynamics after three months of VNS. ON period of the neurostimulation may generate a transient vagal activation reflected on heart rate and RMSSD values, as observed in one of our cases. Conclusion VNS therapy in epilepsy patients seems not to disrupt the cardiac autonomic function. HRV represents a useful tool in evaluating autonomic activity. More extensive studies are needed to further explore cardiac autonomic response after neurostimulation.

Music Recognition Algorithm based on T-S Cognitive Neural Network.

Abstract: The main task of music recognition is to acquire relevant information of music content through processing and feature extraction of audio signals, and then used for comparison, classification, and automatic recording. The cognitive neural network based on T-S model is used to train the network weights with improved genetic algorithm in the paper. The strategy of membership function parameter adjustment is combined with the combination of momentum method and learning rate adaptive adjustment. The new proposed algorithm can be used in the music recognition algorithm by adding a compensation factor related to the input dimension on the membership degree, and the experimental result of the rule disaster caused by the excessive input dimension shows that the new proposed method can be applied to the music recognition system. At the same time, it shows that the accuracy rate of the recognition network is more accurate than that of the other algorithms, and its robustness is better.

Protective Effect of Resveratrol Against Corticosterone-induced Neurotoxicity in PC12 Cells.

Abstract: Objective Resveratrol(RES) is a natural polyphenol which possesses an anti-depressant effect. However, the mechanisms of its anti-depressant effect remain unclear. The aim of the study is to investigate the potential mechanisms in the neuro-protective efficiency in the corticosterone-induced pheochromacytoma 12 (PC12) cells. Methods PC12 cells were treated with 200 μM of corticosterone in the absence or presence of different concentrations of RES for 24 h. Then, cell viability was measured by Cell Counting Kit-8 assay. Apoptosis of PC12 cells was measured by Annexin V-FITC and Propidium iodide (PI) labelling. The expression of apoptosis-related proteins including Bax, Bcl-2, caspase-3 was determined by western blotting. Results The results showed that treatment with 200 μM of corticosterone induced cytotoxicity in PC12 cells. However, different concentrations of RES (2.5μmol/L, 5μmol/L and 10 μmol/L) significantly increased the cell viability, suppressed the apoptosis of PC12 cells, down-regulated Bax and caspase-3 protein expression, and up-regulated Bcl-2 protein expression, compared to the model group (p Conclusion Resveratrol has a protective effect on corticosterone-induced neurotoxicity in PC12 cells, which may be related to the apoptosis via inhibition of apoptosis-related proteins and displays the antidepressant-like effect.

Early Path Nursing on Neurological Function Recovery of Cerebral Infarction.

Abstract: Purpose to study the application of path type early rehabilitation nursing in the nursing of patients with cerebral infarction and to explore its impact on the recovery of neurological function. Methods Patients with acute cerebral infarction in our hospital were randomly divided into two groups. The control group used conventional treatment methods. The experimental group used path type early rehabilitation care based on conventional treatment methods and observed the curative effect. Results The NIHSS scores in the experimental group were significantly lower than those in the control group, and the P value was less than 0.05, which was statistically significant. Conclusion Path type early rehabilitation nursing has a positive effect on the treatment of patients with cerebral infarction, which contributes to the recovery of neurological function of patients and is worthy of promotion in treatment.

MiR-1906 Attenuates Neuropathic Pain in Rats by Regulating the TLR4/mTOR/ Akt Signaling Pathway.

Abstract: Background This study determined the role of miR-1906 in neuropathic pain and proliferation in neuronal cells using a chronic constriction injury (CCI)-induced neuropathic pain (NP) rat model. Methodology NP was induced by CCI. Animals were divided into a sham group, an NP group, and a miR-1906 mimic group, which received 500 nmol/kg of a miR-1906 mimic intrathecally for 10 consecutive days following surgery. The effect of miR-1906 agomir was determined by estimating the thermal and mechanical withdrawal latency; an enzyme-linked immunosorbent assay (ELISA) was used to determine the concentration of proinflammatory mediators. Western blotting and reverse-transcription polymerase chain reaction (RT-PCR) were used to determine protein expression in the spinal tissues of the CCI-induced neuropathic pain rat model. Results Administration of miR-1906 agomir increased the mechanical and thermal withdrawal latency period and the levels of inflammatory mediators compared with the NP group. Western blotting showed that treatment with miR-1906 agomir attenuated the levels of Akt, mTOR, TLR-4, and PI3K proteins in the spinal tissues of the CCI-induced neuropathic pain model. TLR-4 and NF-κB gene expression was lower in the miR-1906 agomir group than in the NP group. Conclusion miR-1906 gene stimulation reduced neuropathic pain by enhancing Akt/nTOR/PI3K and TLR-4/NF-κB pathway regulation.

Description and assessment of a neurosurgery shadowing and research program: A paradigm for early and sustained exposure to academic neurosurgery

Abstract: Objective To describe and assess the educational value of a functional neurosurgery clinical shadowing and research tutorial for pre-medical trainees. Design Program participants observed functional neurosurgery procedures and conducted basic science and clinical research in neurosurgery fields. Former participants completed a brief online survey to evaluate their perspectives and experiences throughout the tutorial. Setting Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Participants 15 pre-medical and post-baccalaureate trainees participated in the tutorial. All former tutorial participants were emailed. Results 11/15 former participants responded to the survey. Survey results suggest that the tutorial program increased participants' understanding of and interest in neurosurgery and related fields in neuroscience. Conclusions The functional neurosurgery medical tutorial provides valuable clinical and research exposure in neurosurgery fields for pre-medical trainees. Our work is a preliminary step in addressing the crucial challenge of training the next generation of neurosurgeon-scientists by providing a pedagogical paradigm for development of formal experiences that integrate original scientific research with clinical neurosurgery exposure.

Characteristics of Cognitive in Children with Learning Difficulties.

Abstract: In order to explore the relationship between cognitive function in children with learning difficulties and social environment, this study uses the Wechsler Intelligence Scale and the self-made general environment questionnaire to investigate 185 children with learning difficulties and compares them with 185 normal children, and gives attention test to 50 children with learning difficulties. The results show that family environment has a certain influence on the children with learning difficulties, they have a significantly lower verbal intelligence quotient (VIQ), performance intelligence quotient (PIQ) and full scale intelligence quotient (FIQ), and the separation of VIQ and P IQ is common among them. As the children with learning difficulties grow older, their ability for abstract generalization tends to decline, which may be a characteristic of their intelligence development. This study aims to compare the functional differences in cortical regions between children with learning difficulties and children without from the perspective of cognitive neuropsychology, so as to provide effective assistance for children with learning difficulties.

Behavior and Hippocampal Epac Signaling to Nicotine CPP in Mice.

Abstract: Tobacco use is a major challenge to public health in the United States and across the world. Many studies have demonstrated that adult men and women differ in their responses to tobacco smoking, however neurobiological studies about the effect of smoking on males and females were limited. Exchange protein directly activated by cAMP (Epac) signaling participates in drug addictive behaviors. In this study, we examined the hippocampal Epac signaling in nicotine-induced place conditioning mice. Nicotine at 0.2 mg/kg and 0.4 mg/kg induced a conditioned place preference (CPP) in male and female mice, respectively. After CPP, male mice presented less anxiety-like behavior as demonstrated by an open-field test. The hippocampal Epac2 protein was elevated in both male and female nicotine place conditioning mice. However, Rap1 protein was elevated and CREB phosphorylation was reduced in female nicotine place conditioning mice. Our data provide direct evidence that hippocampal Epac signaling is altered in nicotine-induced CPP mice. Pharmacology manipulation Epac signaling may open a new avenue for the treatment of nicotine abuse and dependence.

Computational Neuroscience Applied in Surface Roughness Fiber Optic Sensor.

Abstract: Computational neuroscience has been widely used in fiber optic sensor signal output. This paper introduces a method for processing the Surface Roughness Fiber Optic Sensor output signals with a radial basis function neural network. The output signal of the sensor and the laser intensity signal as the light source are added to the input of the RBF neural network at the same time, and with the ability of the RBF neural network to approach the non-linear function with arbitrary precision, to achieve the nonlinear compensation of the sensor and reduction of the effect of changes in laser output light intensity at the same time. The Surface Roughness Fiber Optic Sensor adopting this method has low requirements on the stability of the output power of laser, featuring large measuring range, high accuracy, good repeatability, measuring of special surfaces such as minor area, and the bottom surface of holed etc. The measurements were given and various factors that affect the measurement were analyzed and discussed.

Cognitive Diagnosis of Cultural and Rural Tourism Convergence.

Abstract: Neural networks are widely used in the field of cognitive diagnosis. Cognitive diagnosis can diagnose the subjects' knowledge of cognitive attributes according to their responses, so as to obtain the specific cognitive status of the subjects and provide remedial measures. The studies on the convergence of cultural industry and tourism industry are emerging, but the theoretical system needs to be improved. The research on the convergence mechanism between cultural industry and tourism industry can complement each other on the basis of independent theoretical system, which establishes relationship between the two theoretical systems. Based on the adaptive neural network algorithm and from the perspective of blockchain, this study takes cultural industry and rural tourism industry as examples to diagnose the industry convergence of rural cultural industry and rural tourism industry development, which will further consolidate the theoretical basis for the convergence and development of tourism industry and cultural industry, as well as contribute to promoting development of industry convergence.

Brain gene expression in a novel mouse model of postpartum mood disorder

Abstract: Background Steroid sulfatase (STS) cleaves sulfate groups from steroid hormones; its expression/activity increases in late pregnancy and into the postpartum period. STS-deficient human and mouse mothers display elevated psychopathology and abnormal behaviour respectively; in mice, these effects can be partially normalised by antipsychotic (ziprasidone) administration. Methodology We compared brain gene expression in new mouse mothers administered the STS inhibitor 667-Coumate, or vehicle; significant changes were followed-up with pathway analysis and quantitative polymerase chain reaction (qPCR). Finally, the effects of combined 667-Coumate and ziprasidone administration on expression of the most robustly differentially-expressed genes were examined. Results Surprisingly, no between-group gene expression changes were detected at a False Discovery Rate (FDR)-corrected p<0.1. 1,081 unique expression changes were detected at p<0.05, two top hits were verified by qPCR, and pathway analysis indicated enrichment of genes involved in olfactory transduction. The expression of Stoml3 and Cyp2g1 was unaffected by ziprasidone administration. Conclusions Postpartum behavioural abnormalities in STS-deficient mothers are likely to be the culmination of many small gene expression changes. Our data are consistent with the idea that olfactory function is key to maternal behaviour in mice, and suggest that aberrant expression of olfactory system genes may underlie abnormal maternal behaviour in STS-deficient women.

The role of meditation in college students' neuroticism and mental health

Abstract: A large number of empirical studies have found evidence that neuroticism is related to personality traits, but no one has integrated the relationship between neuroticism and mental health through meta-analysis. As a personality trait, neuroticism reflects the stable tendency of how individuals experience, feel, evaluate negative emotions and make corresponding behavioural responses. By means of meta-analysis, a preliminary dimension of neuroticism is constructed through an open questionnaire and literature review. On this basis, a preliminary neuroticism questionnaire for college students is compiled. The structural model of College Students' neuroticism questionnaire fits well, and has a high correlation with the neuroticism subscale of the simple version of Big Five Personality Questionnaire, which shows that it has a good structural validity. The positive orientation indicators of subjective well-being, life satisfaction and other mental health indicators were also selected. In addition, self-assessment indicators of physical health were selected. It was found that neuroticism was highly correlated with appeal indicators, indicating that the questionnaire of College Students' neuroticism had good validity.

Test and Evaluation of Advertising Effect Based on EEG and Eye Tracker.

Abstract: As a means of marketing communication, advertisements have been applied in the course of enterprise operation. However, in practice, there are many problems with the implementation effect of specific advertisements, so the test and evaluation of the effectiveness of advertising have important practical and theoretical significance. Therefore, this paper uses the EEG and eye movement technology to study the EEG change and eye movement of subjects when viewing advertisements and to conduct processing and analysis of the collected EEG and eye movement indexes. It is expected to provide advertisers with valuable advertising strategies based on the analysis results of EEG change and eye movement experiment.

Radiation Outcome in Mechanical Thrombectomy of Acute Ischemic Stroke.

Abstract: Objective Mechanical thrombectomy is recommended for acute ischemic stroke (AIS) with large artery occlusion. Radiation during the endovascular procedure would increase the risk of skin diseases. We sought to identify radiation outcomes during mechanical thrombectomy. Methodology We prospectively collected and analyzed radiation parameters during mechanical thrombectomy in 41 patients affected with acute cerebral artery occlusion. Results There were 41 cases (68.73 ± 11.05 years) in this study, with a National Institute Health Stroke Scale (NIHSS) score of 15.66 ± 5.94. The time parameters were recorded as following: 84.45 ± 31.66 min (operation duration), 129.71 ± 81.14 s (angiographic run), 16.02 ± 11.03 min (fluoroscopy) and 18.19 ± 11.14 min (angiographic exposure). The doses produced in the procedure were: 1276.43 ± 1647.56 mGy (shot dose), 607.26 ± 412.34 mGy (fluoroscopy) and 1635.52 ± 593.65 mGy (angiographic exposure). Further analysis discovered no association between NIHSS and these time and radiation parameters (P > 0.05). Conclusion This study provided the description of radiation details during mechanical thrombectomy for acute cerebral artery occlusion. The stroke severity would not influence the procedure parameters.

New Orientation of Study on Economic Psychology and Behaviour.

Abstract: Economic psychology refers to the impact of psychological factors on economic changes, and its outward manifestation is economic behaviour. Psychology, as a science studying human psychology and behaviour, has no reason to ignore the study of economic activities. This study summarizes the latest research results and conclusions of economic psychology from three aspects of behaviour level, body signal and other people's movement or displacement. In addition, it expounds the reflection of economic psychology, the reflection of rational human hypothesis of traditional economics and the prospect of future research. From the perspective of economic psychology, it is of great significance to analyse the psychological motivation behind the conflicts and interests in the study of economic psychology and behaviour so as to construct the harmonious behaviour relationship of "psychological contract" on the basis of the rational mechanism of interest distribution.

Chronic Subdural Hematoma (CSH) is Still an Important Clinical Problem. Analysis of 700 Consecutive Patients.

Abstract: Background Chronic subdural hematoma (CSH) is still an important neurosurgical problem and the number of patients increases despite the progress in early diagnosis of cerebral lesions. Methodology We analyzed a group of 700 consecutive patients treated in neurosurgical departments for CSH. Clinical state on admission was evaluated according to the Markwalder scale, all patients had CT studies and were operated using craniotomy or burr holes with closed system drainage techniques. Results More than 50% had extensive intracranial bleeding, almost half of the patients were treated with oral anticoagulants. The patients with extensive fresh bleeding were in significantly worse states on admission and were treated by craniotomy and external capsulectomy (42%). All the others had burr holes and closed system drainage of the subdural space. Results of treatment were acceptable, 2% died, and 1.5% remained vegetative, due to massive hemorrhage and severe neurological deficits on admission. Conclusions Despite a progress in diagnosis, CSH still remains an often cause of severe intracranial complications. The rising number of occurrences of this lesion is strictly connected with a wide use of oral anticoagulants. Surgical removal of CSH still remains the best type of treatment for such lesions.

Early Multidisciplinary Intensive-care Therapy can Improve Outcome of Severe Anti-NMDA-receptor Encephalitis Presenting with Extreme Delta Brush.

Abstract: Anti-N-methyl-D-aspartate receptor encephalitis (Anti-NMDARE) is a synaptic autoimmune encephalitis syndrome mainly affecting young females. An underlying tumor, most commonly ovarian teratomas in young females, may indicate a paraneoplastic syndrome. Prognostic factors of the clinical course of disease and outcome play a central role in view of early administration of second-line immunotherapy and intensive-care therapy. We report a case of severe Anti-NMDARE associated with unfavorable predictors including an extreme delta brush (EDB) electroencephalographic-pattern and high anti-NMDAR-antibody titers in the cerebral spinal fluid (CSF), which necessitated the admission to an intensive care unit. In spite of the poor prognosis, the patient completely recovered; we attribute this to an early escalation to second-line immunotherapy with rituximab and multidisciplinary intensive-care therapy. The present case underlines the relevance of multidisciplinary management for individuals with Anti-NMDARE.

Digital Image Recognition Based on Improved Cognitive Neural Network.

Abstract: This paper presents an innovative cognitive neural network method application in digital image recognition. The following conclusion can be drawn. Each point of the graph is transformed, and the original color of the transformed new coordinates is given to the point. If after all the points have transformed, if there is a point and no point has converted to this point, the point is not given a color. Then this point will form a hole or a stripe, and the color is the color of the point initialization. The innovative method can effectively separate the digital image recognition signal from the mixed signal and maintain the waveform of the source signal with high accuracy, thus laying the foundation for the next step of recognition.

Coping Strategies for Oral Health Problems by People with Schizophrenia.

Abstract: Background Persons with schizophrenia are particularity susceptible to poor oral health. Symptoms of schizophrenia often affect oral health behaviors and lifestyle. The aim was to explore coping strategies used by people with schizophrenia in oral health in order to understand and to best involve them in the management of their own oral health in daily life. Materials and methods This is systematic review reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statements. We included cross-sectional and longitudinal quantitative and qualitative studies that 1) examined coping strategies regarding oral health in persons with schizophrenia or 2) examined coping strategies were used in dental care. We included studies conducted with at least one PWS aged 18 years old more and without restriction on sex, socioeconomic status, or language. Results The 8 studies included suggest that coping strategies depends on complex translation processes that can be either personal (e.g., psychological symptomatology, neuropsychological functioning to adversely affect hope, self-esteem, self-stigma, self-determination, sense of coherence, and resilience) and/or environmental factors (e.g., peer support and efficacy of rehabilitations programs). We further identified that the main factor influencing coping strategies was dental stress situation. Conclusions This review suggests that coping strategies play a crucial role in the recovery process for oral health of PWS. Translation processes in oral health should be more explored in the future to clarify the capacity of PWS to cope with essential self-care in oral health on daily life.

Prediction of Global Value Chain Based on Cognitive Neural Network -Take Chinese Automobile Industry as an Example.

Abstract: Cognitive artificial neural network is a hot research field which is an important part of human intelligence research. In recent years, artificial neural network has been used in the fields of neuroscience, computer science, cognitive science, mathematics and physics. With the Chinese automobile industry as the research object, the global value chain as the research tool, and the promotion of Chinese automobile industry cluster as the research objective, This paper deals with information processing by simulating neural activity in the brain according to the cognitive artificial neural network to study the upgrading of Chinese automobile industry cluster, and puts forward the related suggestion on the upgrading of Chinese automobile industry cluster. This study believes that in order to promote the upgrading of Chinese automobile industry cluster, it's essential to promote the independent innovation of enterprises in the cluster and indispensable to strengthen government support, which has certain guiding significance to the development of Chinese automobile industry cluster.

Cognitive neural mechanism of sports competition pressure source

Abstract: At sports events, the athletes by the pressure source is varied, based on the stress status of athletes, many athletes stress related experts at home and abroad to design questionnaire, questionnaire and sports events for athletes with often life process of in-depth and meticulous investigation, has formed the one whole set athletes pressure source of cognitive neuroscience assessment system, sports competition for athlete’s "escort". By participating in state general administration of sports scientific research project " management system of athlete competition pressure cognitive neuroscience" the development of using psychological pressure on athletes’ source data, the application of natural language processing and machine learning technology research these data, mainly using clustering algorithm and recommendation algorithm, thus forming pressure source research results are applied in sports competitions.

Influence of Cognitive Neuroscience on Contemporary Philosophy of Science.

Abstract: The study of contemporary philosophy of science based on cognitive neuroscience has strongly promoted the philosophy study of brain cognitive problems. It has pointed out the research direction for human to explore the relationship between the traditional mind and brain while systematically reflecting and investigating the theoretical basis and research method of cognitive neuroscience. Therefore, this study explores the influence and the significance of cognitive neuroscience on contemporary philosophy of science.

CSF Proteomics of Patients with Hydrocephalus and Subarachnoid Haemorrhage.

Abstract: Background The pathophysiology of brain injury following aneurysmal subarachnoid haemorrhage (SAH) is associated with numerous mediators. The aim of the study is to analyse protein changes after SAH in cerebrospinal fluid (CSF) using mass spectrometry (MS). Methods CSF samples were obtained from forty-four control subjects, seven good outcome and ten poor outcome SAH patients. CSF samples were collected at specific time intervals after SAH (days 1, 5 and 10). MALDI-TOF (Matrix Assisted Laser Desorption/Ionization Time-of-Flight) and ClinProTools software were utilised for MS, MS/MS (Mass Spectrometry) spectra collection and analysis. Selected masses were identified. The MALDI-TOF profiling experiments allowed for the targeted selection of potential markers in SAH. The study was performed in three steps by comparison of CSF samples: (1) from the control group and SAH patients (both good and poor outcome groups); (2) collected on days 1, 5 and 10 within the groups of poor SAH and good SAH patients, respectively; (3) from poor outcome SAH and good outcome patients at days 1, 5 and 10. Results 15 new proteins whose CSF level is alternated by SAH presence, SAH treatment outcome and time passed since aneurysm rupture were identified. Conclusions We demonstrated new proteins which might play a role in different stages of subarachnoid haemorrhage and could be a new target for further investigation.

Clinical study of neurology nursing on cerebral apoplexy rehabilitation

Abstract: The incidence of cerebral apoplexy has been on the rise in recent years, and research on the treatment and care of this disease has also received much attention. Therefore, a clinical study of neurological care for cerebral apoplexy rehabilitation care was conducted. Firstly, the Diffie-Hellman key exchange algorithm is introduced, and then the Diffie-Hellman prediction model is established. The patient is taken as an example to carry out simulation test, and the prediction model is compared with the real data. The data of the network model training set, the verification set and the test set are obtained. Patients were divided into observation group and control group by random number table method. The evaluation indicators included the treatment efficiency and the quality of life of the two groups. The results showed that the effective rate of the observation group was higher than that of the control group, and the difference between the two groups was statistically significant (P < 0.05). The experiment proves that the clinical effect of neurological nursing on cerebral apoplexy rehabilitation nursing is positive, which can improve the limb movement and self-living ability of patients, improve the quality of life of patients and improve patient satisfaction. Clinical study of neurology nursing on cerebral apoplexy rehabilitation nursing is discussed in this paper, and the rehabilitation nursing method and formal standardized nursing process of this disease are standardized.

L-655,708 Does not Prevent Isoflurane-induced Memory Deficits in Old Mice.

Abstract: Background General anesthesia and increasing age are two main risk factors for postoperative cognitive dysfunction (POCD). Effective agents for the prevention or treatment of POCD are urgently needed. L-655,708, an inverse agonist of α5 subunit-containing γ-aminobutyric acid subtype A (α5GABAA) receptors, can prevent anesthesia-induced memory deficits in young animals. However, there is a lack of evidence of its efficacy in old animals. Methodology Young (3- to 5-month-old) and old (18- to 20-month-old) mice were given an inhalation of 1.33% isoflurane for 1 hour and their associative memory was evaluated 24 hours after anesthesia using fear-conditioning tests (FCTs). To evaluate the effect of L-655,708, mice received intraperitoneal injections of L-655,708 (0.7 mg/kg) or vehicle 30 minutes before anesthesia. Results Old mice exhibited impaired memory and lower hippocampal α5GABAA levels than young mice under physiological conditions. Pre-injections of L-655,708 significantly alleviated isoflurane-induced memory decline in young mice, but not in old mice. Conclusions L-655,708 is not as effective for the prevention of POCD in old mice as it is in young mice. The use of inverse agonists of α5GABAA in preventing POCD in old patients should be carefully considered.