Journal ArticleDOI
3-(Dichloroacetyl)chromone;A New Building Block for the Synthesis of Formylated Purine Isosteres:Design and Synthesis of Fused α-(Formyl)pyridines
Viktor O. Iaroshenko,Satenik Mkrtchyan,Gagik Ghazaryan,Ani Hakobyan,Aneela Maalik,Linda Supe,Alexander Villinger,Andrei A. Tolmachev,Dmytro Ostrovskyi,Vyacheslav Ya. Sosnovskikh,Tariel V. Ghochikyan,Peter Langer +11 more
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TLDR
The first synthesis of 3-dichloroacetylchromone from 3-dimethylamino-1-(2-hydroxyphenyl)propen-1-one and dichlo- roacetyl chloride is described in this paper.Abstract:
The first synthesis of 3-(dichloroacetyl)chromone from 3-(dimethylamino)-1-(2-hydroxyphenyl)propen-1-one and dichlo- roacetyl chloride is described. The reaction of electron-rich amino- heterocycles with 3-(dichloroacetyl)chromone provides a set of diverse fused pyridines bearing the CHCl2-substituent at the a-posi- tion of the pyridine core. Subsequent hydrolysis leads to the forma- tion of annulated a-(formyl)pyridines.read more
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4-Chloro-3-(trifluoroacetyl)- and 4-chloro-3-(methoxalyl)coumarins as novel and efficient building blocks for the regioselective synthesis of 3,4-fused coumarins
Viktor O. Iaroshenko,Viktor O. Iaroshenko,Friedrich Erben,Satenik Mkrtchyan,Satenik Mkrtchyan,Ani Hakobyan,Ani Hakobyan,Marcelo Vilches-Herrera,Sergii Dudkin,Alina Bunescu,Alexander Villinger,Vyacheslav Ya. Sosnovskikh,Peter Langer +12 more
TL;DR: In this article, the starting materials were prepared by the reaction of 4-hydroxycoumarin with trifluoroacetic anhydride and methyl 2-chloro-2-oxoacetate in the presence of trimethylsilylchloride.
Journal ArticleDOI
One-pot, three-component synthesis of 7-azaindole derivatives from N-substituted 2-amino-4-cyanopyrroles, various aldehydes, and active methylene compounds.
Marcelo Vilches-Herrera,Ingo Knepper,Nayane de Souza,Alexander Villinger,Vyacheslav Ya. Sosnovskikh,Viktor O. Iaroshenko,Viktor O. Iaroshenko +6 more
TL;DR: An efficient and practical route to 7-azaindole framework has been developed by one-pot, three-component cyclocondensation of N-substituted 2-amino-4-cyanopyrroles, various aldehydes, and active methylene compounds in ethanol or acetic acid at reflux.
Journal ArticleDOI
Design, Synthesis, and Anticancer Activity of 1,2,3-Triazole Linked 1,2-Isoxazole-imidazo[4,5-b]pyridine Derivatives
TL;DR: In this paper, a series of novel 1,2-isoxazole-pyridobenzimidazole is synthesized, which are supported by 1H and 13C NMR, and mass spectra.
Journal ArticleDOI
A general strategy for the synthesis of difluoromethyl-containing pyrazoles, pyridines and pyrimidines
Viktor O. Iaroshenko,Viktor O. Iaroshenko,Verena Specowius,Katharina Vlach,Marcelo Vilches-Herrera,Dmytro Ostrovskyi,Satenik Mkrtchyan,Alexander Villinger,Peter Langer +8 more
TL;DR: In this paper, the CF 2 Cl-substituted 1,3-dicarbonyl compounds were used to obtain difluoromethyl-containing heteroannulated pyridines, pyrimidines and pyrazoles.
Journal ArticleDOI
2,3-Unsubstituted chromones and their enaminone precursors as versatile reagents for the synthesis of fused pyridines
Viktor O. Iaroshenko,Viktor O. Iaroshenko,Satenik Mkrtchyan,Ashot Gevorgyan,Ashot Gevorgyan,Mariia Miliutina,Alexander Villinger,Dmytro Volochnyuk,Vyacheslav Ya. Sosnovskikh,Peter Langer +9 more
TL;DR: A divergent and regioselective approach to fused pyridines was developed through formal [3 + 3] cyclocondensations from simple 2,3-unsubstituted chromones or their enaminone precursors.
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