Journal ArticleDOI
A CNS specific proteoglycan associated with astrocytes in rat optic nerve.
TLDR
A novel CNS specific keratan sulfate proteoglycan is identified by a monoclonal antibody (mAb) TED15, being present in the optic nerve but absent from the retina.About:
This article is published in Brain Research.The article was published on 1992-01-31. It has received 39 citations till now. The article focuses on the topics: Optic nerve & Proteoglycan.read more
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Journal ArticleDOI
The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury.
TL;DR: Combined glial fibrillary acidic protein (GFAP) immunohistochemistry and in situ hybridization demonstrated that GFAP astrocytes constituted a source of neurocan production after spinal cord injury, establishing a CSPG-rich matrix that persists for up to 2 months following injury.
Journal ArticleDOI
Interactions of developing neurons with the extracellular matrix
TL;DR: Recent findings on neuronal interactions with the ECM are discussed, and evidence has accumulated to indicate that the cell surface molecules that mediate cell-cell and cell-ECM interactions are not longer regarded as only adhesive or mechanical.
Journal ArticleDOI
Activated macrophages and the blood-brain barrier: inflammation after CNS injury leads to increases in putative inhibitory molecules
Michael T. Fitch,Jerry Silver +1 more
TL;DR: It is determined that the presence of degenerating and dying axons injured by direct trauma does not provide a sufficient signal to induce the increases in proteoglycans observed after injury, and Activated macrophages, their products, or other serum components that cross a compromised blood-brain barrier may provide a stimulus for changes in extracellular matrix molecules after CNS injury.
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The CNS lesion scar: new vistas on an old regeneration barrier
TL;DR: Current knowledge on the structural and functional features of the lesion scar are summarized and the development of therapeutic interventions to override this regeneration barrier is summarized.
Journal ArticleDOI
Nervous system proteoglycans as modulators of neurite outgrowth.
TL;DR: This review summarises the evidences indicating that proteoglycans have an important role as modulators of neurite outgrowth and neuronal polarity in the vertebrate Central Nervous System and special emphasis will be placed on those studies that have shown that proteglycans of certain subtypes inhibit neurite extension either during the development and/or the regeneration of the vertebrates Central Nerve System.
References
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Journal ArticleDOI
Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter
Pico Caroni,Martin E. Schwab +1 more
TL;DR: It is concluded that the nonpermissive substrate properties of CNS white matter are due to these membrane proteins on the surface of differentiated oligodendrocytes and to their in vivo product, myelin.
Journal ArticleDOI
Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro
TL;DR: It is demonstrated that KS/CS-PG is inhibitory to embryonic dorsal root ganglia neurites in vitro and that complete inhibition requires contributions from both KS and CS moieties.
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The expression and posttranslational modification of a neuron-specific β-tubulin isotype during chick embryogenesis
TL;DR: Western blots of protein separated by two-dimensional gel electrophoresis reveal that the number of beta III isoforms increases from one to three during neural development, which indicates that beta III is a substrate for developmentally regulated, multiple-site posttranslational modification.
Journal ArticleDOI
Identification of a monoclonal antibody that specifically recognizes corneal and skeletal keratan sulfate. Monoclonal antibodies to cartilage proteoglycan
TL;DR: The 1/20/5-D-4 monoclonal antibody appears to recognize a common determinant in their polysaccharide moieties, consistent with several biochemical analyses showing the absence of keratan sulfate in proteoglycan synthesised by this tissue.
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A quantitative immunohistochemical study of macroglial cell development in the rat optic nerve: In vivo evidence for two distinct astrocyte lineages
TL;DR: In this article, the authors used three antibodies (anti-galactocerebroside (GC), anti-glial fibrillary acidic protein (GFAP), and the A2B5 monoclonal antibody) to examine the timing and sequence of the development of the three types of glial cells in vivo.